CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. A HuGE Review

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Abstract

The cytochrome P-450c17alpha (CYP17 ) gene, located on chromosome 10q24.3, encodes the enzyme cytochrome P-450c17alpha, which functions at key branch points in steroid hormone biosynthesis. Three polymorphisms have been described, but only the single base-pair change in the 5'-untranslated region (5'-UTR) has been investigated to any great extent. In single studies, the variant was associated with reduced messenger RNA level in ovarian cells but not with messenger RNA level in breast tissue. Homozygosity for the 5'-UTR variant is most common in East Asian (32%) and Japanese (22%) populations and is less common among White (mainly European and North American (14%)) and Black (mainly African-American (13%)) populations, but selection biases are likely to have affected these frequency estimates. Genotype appears to influence circulating estrogen levels in premenopausal women, while studies of relations with hormone levels in men have produced inconclusive results. However, relatively few studies have been conducted. Seven of 11 retrospective studies suggested a modest association between genotype and age at menarche. Random error in recall of age at menarche is likely to have attenuated this relation. Associations between genotype and postmenopausal estrogen use and bone mass have been observed in single studies. Further investigation of relations between genotype and hormone levels, exogenous hormone use, and markers of hormonal status may advance understanding of hormonally mediated diseases.

Original languageEnglish
Pages (from-to)729-740
Number of pages11
JournalAmerican Journal of Epidemiology
Volume160
Issue number8
DOIs
Publication statusPublished - Oct 2004

Keywords

  • CYP17
  • epidemiology
  • genetics
  • gonadal steroid hormones
  • hormones
  • menarche
  • polymorphism (genetics)
  • steroid 17-alpha-hydroxylase
  • BREAST-CANCER RISK
  • POLYCYSTIC-OVARY-SYNDROME
  • SERUM ANDROGEN CONCENTRATIONS
  • PROMOTER REGION POLYMORPHISM
  • AGE 40 YEARS
  • PROSTATE-CANCER
  • CYTOCHROME P450C17-ALPHA
  • POSTMENOPAUSAL WOMEN
  • REPLACEMENT THERAPY
  • NO ASSOCIATION

Cite this

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title = "CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. A HuGE Review",
abstract = "The cytochrome P-450c17alpha (CYP17 ) gene, located on chromosome 10q24.3, encodes the enzyme cytochrome P-450c17alpha, which functions at key branch points in steroid hormone biosynthesis. Three polymorphisms have been described, but only the single base-pair change in the 5'-untranslated region (5'-UTR) has been investigated to any great extent. In single studies, the variant was associated with reduced messenger RNA level in ovarian cells but not with messenger RNA level in breast tissue. Homozygosity for the 5'-UTR variant is most common in East Asian (32{\%}) and Japanese (22{\%}) populations and is less common among White (mainly European and North American (14{\%})) and Black (mainly African-American (13{\%})) populations, but selection biases are likely to have affected these frequency estimates. Genotype appears to influence circulating estrogen levels in premenopausal women, while studies of relations with hormone levels in men have produced inconclusive results. However, relatively few studies have been conducted. Seven of 11 retrospective studies suggested a modest association between genotype and age at menarche. Random error in recall of age at menarche is likely to have attenuated this relation. Associations between genotype and postmenopausal estrogen use and bone mass have been observed in single studies. Further investigation of relations between genotype and hormone levels, exogenous hormone use, and markers of hormonal status may advance understanding of hormonally mediated diseases.",
keywords = "CYP17, epidemiology, genetics, gonadal steroid hormones, hormones, menarche, polymorphism (genetics), steroid 17-alpha-hydroxylase, BREAST-CANCER RISK, POLYCYSTIC-OVARY-SYNDROME, SERUM ANDROGEN CONCENTRATIONS, PROMOTER REGION POLYMORPHISM, AGE 40 YEARS, PROSTATE-CANCER, CYTOCHROME P450C17-ALPHA, POSTMENOPAUSAL WOMEN, REPLACEMENT THERAPY, NO ASSOCIATION",
author = "Linda Sharp and Cardy, {Amanda Hamilton} and Cotton, {Seonaidh Claire} and Julian Little",
year = "2004",
month = "10",
doi = "10.1093/aje/kwh287",
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journal = "American Journal of Epidemiology",
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TY - JOUR

T1 - CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. A HuGE Review

AU - Sharp, Linda

AU - Cardy, Amanda Hamilton

AU - Cotton, Seonaidh Claire

AU - Little, Julian

PY - 2004/10

Y1 - 2004/10

N2 - The cytochrome P-450c17alpha (CYP17 ) gene, located on chromosome 10q24.3, encodes the enzyme cytochrome P-450c17alpha, which functions at key branch points in steroid hormone biosynthesis. Three polymorphisms have been described, but only the single base-pair change in the 5'-untranslated region (5'-UTR) has been investigated to any great extent. In single studies, the variant was associated with reduced messenger RNA level in ovarian cells but not with messenger RNA level in breast tissue. Homozygosity for the 5'-UTR variant is most common in East Asian (32%) and Japanese (22%) populations and is less common among White (mainly European and North American (14%)) and Black (mainly African-American (13%)) populations, but selection biases are likely to have affected these frequency estimates. Genotype appears to influence circulating estrogen levels in premenopausal women, while studies of relations with hormone levels in men have produced inconclusive results. However, relatively few studies have been conducted. Seven of 11 retrospective studies suggested a modest association between genotype and age at menarche. Random error in recall of age at menarche is likely to have attenuated this relation. Associations between genotype and postmenopausal estrogen use and bone mass have been observed in single studies. Further investigation of relations between genotype and hormone levels, exogenous hormone use, and markers of hormonal status may advance understanding of hormonally mediated diseases.

AB - The cytochrome P-450c17alpha (CYP17 ) gene, located on chromosome 10q24.3, encodes the enzyme cytochrome P-450c17alpha, which functions at key branch points in steroid hormone biosynthesis. Three polymorphisms have been described, but only the single base-pair change in the 5'-untranslated region (5'-UTR) has been investigated to any great extent. In single studies, the variant was associated with reduced messenger RNA level in ovarian cells but not with messenger RNA level in breast tissue. Homozygosity for the 5'-UTR variant is most common in East Asian (32%) and Japanese (22%) populations and is less common among White (mainly European and North American (14%)) and Black (mainly African-American (13%)) populations, but selection biases are likely to have affected these frequency estimates. Genotype appears to influence circulating estrogen levels in premenopausal women, while studies of relations with hormone levels in men have produced inconclusive results. However, relatively few studies have been conducted. Seven of 11 retrospective studies suggested a modest association between genotype and age at menarche. Random error in recall of age at menarche is likely to have attenuated this relation. Associations between genotype and postmenopausal estrogen use and bone mass have been observed in single studies. Further investigation of relations between genotype and hormone levels, exogenous hormone use, and markers of hormonal status may advance understanding of hormonally mediated diseases.

KW - CYP17

KW - epidemiology

KW - genetics

KW - gonadal steroid hormones

KW - hormones

KW - menarche

KW - polymorphism (genetics)

KW - steroid 17-alpha-hydroxylase

KW - BREAST-CANCER RISK

KW - POLYCYSTIC-OVARY-SYNDROME

KW - SERUM ANDROGEN CONCENTRATIONS

KW - PROMOTER REGION POLYMORPHISM

KW - AGE 40 YEARS

KW - PROSTATE-CANCER

KW - CYTOCHROME P450C17-ALPHA

KW - POSTMENOPAUSAL WOMEN

KW - REPLACEMENT THERAPY

KW - NO ASSOCIATION

U2 - 10.1093/aje/kwh287

DO - 10.1093/aje/kwh287

M3 - Article

VL - 160

SP - 729

EP - 740

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 8

ER -