Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus

Xiaoling Wang, Jioji Tabudravu, Mostafa Rateb, Krystal Joan Annand, Zhiwei Qin, Marcel Jaspars, Zixin Deng, Yi Yu, Hai Deng

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The gene cluster directing actinomycin G biosynthesis in Streptomyces iakyrus has been identified and sequenced. It contains one actinomycin synthetase I (ACMS I) gene and two copies of ACMS II and III genes. Genetic analysis demonstrates a unique partnership between the putative hydroxylation and chlorination activities as both acmG8 and acmG9 genes need to be transcribed for the biosynthesis of actinomycin G2-3, respectively.

Original languageEnglish
Pages (from-to)1286-1289
Number of pages4
JournalMolecular BioSystems
Volume9
Issue number6
Early online date25 Mar 2013
DOIs
Publication statusPublished - Jun 2013

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Streptomyces
Multigene Family
Genes
Halogenation
Dactinomycin
Hydroxylation
actinomycin G

Keywords

  • anti-bacterial agents
  • base sequence
  • DNA, bacterial
  • dactinomycin
  • genes, bacterial
  • halogenation
  • hydroxylation
  • molecular sequence data
  • multienzyme complexes
  • multigene family
  • nucleotidyltransferases
  • peptide synthases
  • streptomyces

Cite this

Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus. / Wang, Xiaoling; Tabudravu, Jioji; Rateb, Mostafa; Annand, Krystal Joan; Qin, Zhiwei; Jaspars, Marcel; Deng, Zixin; Yu, Yi ; Deng, Hai.

In: Molecular BioSystems, Vol. 9, No. 6, 06.2013, p. 1286-1289.

Research output: Contribution to journalArticle

Wang, Xiaoling ; Tabudravu, Jioji ; Rateb, Mostafa ; Annand, Krystal Joan ; Qin, Zhiwei ; Jaspars, Marcel ; Deng, Zixin ; Yu, Yi ; Deng, Hai. / Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus. In: Molecular BioSystems. 2013 ; Vol. 9, No. 6. pp. 1286-1289.
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AU - Qin, Zhiwei

AU - Jaspars, Marcel

AU - Deng, Zixin

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KW - genes, bacterial

KW - halogenation

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KW - molecular sequence data

KW - multienzyme complexes

KW - multigene family

KW - nucleotidyltransferases

KW - peptide synthases

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