Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus

Xiaoling Wang, Jioji Tabudravu, Mostafa Rateb, Krystal Joan Annand, Zhiwei Qin, Marcel Jaspars, Zixin Deng, Yi Yu, Hai Deng

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The gene cluster directing actinomycin G biosynthesis in Streptomyces iakyrus has been identified and sequenced. It contains one actinomycin synthetase I (ACMS I) gene and two copies of ACMS II and III genes. Genetic analysis demonstrates a unique partnership between the putative hydroxylation and chlorination activities as both acmG8 and acmG9 genes need to be transcribed for the biosynthesis of actinomycin G2-3, respectively.

Original languageEnglish
Pages (from-to)1286-1289
Number of pages4
JournalMolecular BioSystems
Volume9
Issue number6
Early online date25 Mar 2013
DOIs
Publication statusPublished - Jun 2013

Keywords

  • anti-bacterial agents
  • base sequence
  • DNA, bacterial
  • dactinomycin
  • genes, bacterial
  • halogenation
  • hydroxylation
  • molecular sequence data
  • multienzyme complexes
  • multigene family
  • nucleotidyltransferases
  • peptide synthases
  • streptomyces

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