Identification of biphenylcarboxylic acid derivatives as a novel class of bone resorption inhibitors

R. J. van't Hof, A. I. Idris, Susan Ridge, James Edward Dunford, Iain Robert Greig, S Ralston

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A novel class of biphenylearboxylic acid derivatives are described that inhibit osteoclastic bone resorption in vitro by promoting osteoclast apoptosis and that prevent ovariectomy-induced bone loss in vivo. The compounds act by a novel mechanism that seems to be distinct from existing antiresorptive drugs.

Original languageEnglish
Pages (from-to)1651-1660
Number of pages9
JournalJournal of Bone and Mineral Research
Volume19
Issue number10
DOIs
Publication statusPublished - Oct 2004

Keywords

  • osteoclast
  • resorption
  • inhibitor
  • osteoblast
  • mouse
  • nitric-oxide
  • in-vitro
  • containing bisphosphonates
  • osteoclast formation
  • osteoperosis
  • macrophages
  • prevention
  • hormone
  • trials
  • vivo

Cite this

Identification of biphenylcarboxylic acid derivatives as a novel class of bone resorption inhibitors. / van't Hof, R. J.; Idris, A. I.; Ridge, Susan; Dunford, James Edward; Greig, Iain Robert; Ralston, S.

In: Journal of Bone and Mineral Research, Vol. 19, No. 10, 10.2004, p. 1651-1660.

Research output: Contribution to journalArticle

van't Hof, R. J. ; Idris, A. I. ; Ridge, Susan ; Dunford, James Edward ; Greig, Iain Robert ; Ralston, S. / Identification of biphenylcarboxylic acid derivatives as a novel class of bone resorption inhibitors. In: Journal of Bone and Mineral Research. 2004 ; Vol. 19, No. 10. pp. 1651-1660.
@article{5b0e9e6027cd4f1384d7e3d67e96e6c9,
title = "Identification of biphenylcarboxylic acid derivatives as a novel class of bone resorption inhibitors",
abstract = "A novel class of biphenylearboxylic acid derivatives are described that inhibit osteoclastic bone resorption in vitro by promoting osteoclast apoptosis and that prevent ovariectomy-induced bone loss in vivo. The compounds act by a novel mechanism that seems to be distinct from existing antiresorptive drugs.",
keywords = "osteoclast, resorption, inhibitor, osteoblast, mouse, nitric-oxide, in-vitro, containing bisphosphonates, osteoclast formation, osteoperosis, macrophages, prevention, hormone, trials, vivo",
author = "{van't Hof}, {R. J.} and Idris, {A. I.} and Susan Ridge and Dunford, {James Edward} and Greig, {Iain Robert} and S Ralston",
year = "2004",
month = "10",
doi = "10.1359/jbmr.2004.19.10.1651",
language = "English",
volume = "19",
pages = "1651--1660",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "WILEY-BLACKWELL",
number = "10",

}

TY - JOUR

T1 - Identification of biphenylcarboxylic acid derivatives as a novel class of bone resorption inhibitors

AU - van't Hof, R. J.

AU - Idris, A. I.

AU - Ridge, Susan

AU - Dunford, James Edward

AU - Greig, Iain Robert

AU - Ralston, S

PY - 2004/10

Y1 - 2004/10

N2 - A novel class of biphenylearboxylic acid derivatives are described that inhibit osteoclastic bone resorption in vitro by promoting osteoclast apoptosis and that prevent ovariectomy-induced bone loss in vivo. The compounds act by a novel mechanism that seems to be distinct from existing antiresorptive drugs.

AB - A novel class of biphenylearboxylic acid derivatives are described that inhibit osteoclastic bone resorption in vitro by promoting osteoclast apoptosis and that prevent ovariectomy-induced bone loss in vivo. The compounds act by a novel mechanism that seems to be distinct from existing antiresorptive drugs.

KW - osteoclast

KW - resorption

KW - inhibitor

KW - osteoblast

KW - mouse

KW - nitric-oxide

KW - in-vitro

KW - containing bisphosphonates

KW - osteoclast formation

KW - osteoperosis

KW - macrophages

KW - prevention

KW - hormone

KW - trials

KW - vivo

U2 - 10.1359/jbmr.2004.19.10.1651

DO - 10.1359/jbmr.2004.19.10.1651

M3 - Article

VL - 19

SP - 1651

EP - 1660

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 10

ER -