Identification of biphenylcarboxylic acid derivatives as a novel class of bone resorption inhibitors

R. J. van't Hof, A. I. Idris, Susan Ridge, James Edward Dunford, Iain Robert Greig, S Ralston

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A novel class of biphenylearboxylic acid derivatives are described that inhibit osteoclastic bone resorption in vitro by promoting osteoclast apoptosis and that prevent ovariectomy-induced bone loss in vivo. The compounds act by a novel mechanism that seems to be distinct from existing antiresorptive drugs.

Original languageEnglish
Pages (from-to)1651-1660
Number of pages9
JournalJournal of Bone and Mineral Research
Volume19
Issue number10
DOIs
Publication statusPublished - Oct 2004

Keywords

  • osteoclast
  • resorption
  • inhibitor
  • osteoblast
  • mouse
  • nitric-oxide
  • in-vitro
  • containing bisphosphonates
  • osteoclast formation
  • osteoperosis
  • macrophages
  • prevention
  • hormone
  • trials
  • vivo

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