Abstract
A novel class of biphenylearboxylic acid derivatives are described that inhibit osteoclastic bone resorption in vitro by promoting osteoclast apoptosis and that prevent ovariectomy-induced bone loss in vivo. The compounds act by a novel mechanism that seems to be distinct from existing antiresorptive drugs.
| Original language | English |
|---|---|
| Pages (from-to) | 1651-1660 |
| Number of pages | 9 |
| Journal | Journal of Bone and Mineral Research |
| Volume | 19 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2004 |
Keywords
- osteoclast
- resorption
- inhibitor
- osteoblast
- mouse
- nitric-oxide
- in-vitro
- containing bisphosphonates
- osteoclast formation
- osteoperosis
- macrophages
- prevention
- hormone
- trials
- vivo
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