Identification of the cerebral effects of paracetamol in healthy subjects

an fMRI study

Olivier De Coster, Patrice Forget (Corresponding Author), Johan De Mey, Peter Van Schuerbeek, Jan Poelaert

Research output: Contribution to journalArticle

Abstract

Introduction:
Paracetamol is commonly used for its antipyretic properties and analgesic effects, but the central mechanism remains elusive. We designed a study in healthy volunteers to detect the central functional working mechanism of paracetamol.

Subjects, material and methods:
A total of 20 subjects had a baseline functional magnetic resonance imaging (fMRI) before the intake of 1000 mg paracetamol orally; 60 minutes later, a second fMRI was made aiming detection of regional blood flow differences.

Results:
A decreased connectivity was observed in the ventral volume of interest (VOI), with the posterior cingulate (with both the left anterior cingulate cortex (ACC) and right ACC: respectively, Ke = 576; t = −6.8894 and Ke = 185; t = −4.8178) and the inferior temporal left (Ke = 103; t = −5.0993); in the combined ventral and dorsal VOIs, the posterior cingulate (with the left ACC; Ke = 149; t = −4.5658) and, both with the right ACC, the inferior temporal left (Ke = 88; t = −3.8456) and the inferior frontal gyrus (Ke = 86; t = −4.3937) had a decrease in connectivity. An increase was seen in other regions, including, among others, the middle frontal and temporal gyri (respectively, Ke = 85; t = 4.4256 and Ke = 85; t = 5.6851), the inferior frontal (with the left ACC: Ke = 165; t = 4.4998) and the superior frontal gyrus (with the right ACC; Ke = 281; t = 4.5992), and the post/precentral gyrus (with the right ACC, respectively, Ke = 102; t = 6.0582 and Ke = 105; t = 4.0776).

Conclusions:
On fMRIs in healthy volunteers, the ingestion of paracetamol affects connections with the ACC. This suggests a central effect of paracetamol in cerebral areas known to be associated with pain. Further studies are needed to demonstrate the same effects in acute and chronic pain states.
Original languageEnglish
JournalBritish Journal of Pain
Early online date4 Jun 2019
DOIs
Publication statusE-pub ahead of print - 4 Jun 2019

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Gyrus Cinguli
Acetaminophen
Healthy Volunteers
Magnetic Resonance Imaging
Prefrontal Cortex
Antipyretics
Regional Blood Flow
Acute Pain
Frontal Lobe
Temporal Lobe
Chronic Pain
Analgesics
Eating
Pain

Keywords

  • paracetemol
  • fMRI
  • pharmacology
  • brain
  • pain management

Cite this

Identification of the cerebral effects of paracetamol in healthy subjects : an fMRI study. / Coster, Olivier De; Forget, Patrice (Corresponding Author); Mey, Johan De; Schuerbeek, Peter Van; Poelaert, Jan.

In: British Journal of Pain, 04.06.2019.

Research output: Contribution to journalArticle

Coster, Olivier De ; Forget, Patrice ; Mey, Johan De ; Schuerbeek, Peter Van ; Poelaert, Jan. / Identification of the cerebral effects of paracetamol in healthy subjects : an fMRI study. In: British Journal of Pain. 2019.
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T1 - Identification of the cerebral effects of paracetamol in healthy subjects

T2 - an fMRI study

AU - Coster, Olivier De

AU - Forget, Patrice

AU - Mey, Johan De

AU - Schuerbeek, Peter Van

AU - Poelaert, Jan

PY - 2019/6/4

Y1 - 2019/6/4

N2 - Introduction:Paracetamol is commonly used for its antipyretic properties and analgesic effects, but the central mechanism remains elusive. We designed a study in healthy volunteers to detect the central functional working mechanism of paracetamol.Subjects, material and methods:A total of 20 subjects had a baseline functional magnetic resonance imaging (fMRI) before the intake of 1000 mg paracetamol orally; 60 minutes later, a second fMRI was made aiming detection of regional blood flow differences.Results:A decreased connectivity was observed in the ventral volume of interest (VOI), with the posterior cingulate (with both the left anterior cingulate cortex (ACC) and right ACC: respectively, Ke = 576; t = −6.8894 and Ke = 185; t = −4.8178) and the inferior temporal left (Ke = 103; t = −5.0993); in the combined ventral and dorsal VOIs, the posterior cingulate (with the left ACC; Ke = 149; t = −4.5658) and, both with the right ACC, the inferior temporal left (Ke = 88; t = −3.8456) and the inferior frontal gyrus (Ke = 86; t = −4.3937) had a decrease in connectivity. An increase was seen in other regions, including, among others, the middle frontal and temporal gyri (respectively, Ke = 85; t = 4.4256 and Ke = 85; t = 5.6851), the inferior frontal (with the left ACC: Ke = 165; t = 4.4998) and the superior frontal gyrus (with the right ACC; Ke = 281; t = 4.5992), and the post/precentral gyrus (with the right ACC, respectively, Ke = 102; t = 6.0582 and Ke = 105; t = 4.0776).Conclusions:On fMRIs in healthy volunteers, the ingestion of paracetamol affects connections with the ACC. This suggests a central effect of paracetamol in cerebral areas known to be associated with pain. Further studies are needed to demonstrate the same effects in acute and chronic pain states.

AB - Introduction:Paracetamol is commonly used for its antipyretic properties and analgesic effects, but the central mechanism remains elusive. We designed a study in healthy volunteers to detect the central functional working mechanism of paracetamol.Subjects, material and methods:A total of 20 subjects had a baseline functional magnetic resonance imaging (fMRI) before the intake of 1000 mg paracetamol orally; 60 minutes later, a second fMRI was made aiming detection of regional blood flow differences.Results:A decreased connectivity was observed in the ventral volume of interest (VOI), with the posterior cingulate (with both the left anterior cingulate cortex (ACC) and right ACC: respectively, Ke = 576; t = −6.8894 and Ke = 185; t = −4.8178) and the inferior temporal left (Ke = 103; t = −5.0993); in the combined ventral and dorsal VOIs, the posterior cingulate (with the left ACC; Ke = 149; t = −4.5658) and, both with the right ACC, the inferior temporal left (Ke = 88; t = −3.8456) and the inferior frontal gyrus (Ke = 86; t = −4.3937) had a decrease in connectivity. An increase was seen in other regions, including, among others, the middle frontal and temporal gyri (respectively, Ke = 85; t = 4.4256 and Ke = 85; t = 5.6851), the inferior frontal (with the left ACC: Ke = 165; t = 4.4998) and the superior frontal gyrus (with the right ACC; Ke = 281; t = 4.5992), and the post/precentral gyrus (with the right ACC, respectively, Ke = 102; t = 6.0582 and Ke = 105; t = 4.0776).Conclusions:On fMRIs in healthy volunteers, the ingestion of paracetamol affects connections with the ACC. This suggests a central effect of paracetamol in cerebral areas known to be associated with pain. Further studies are needed to demonstrate the same effects in acute and chronic pain states.

KW - paracetemol

KW - fMRI

KW - pharmacology

KW - brain

KW - pain management

UR - https://doi.org/10.1177/2049463719854483

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DO - 10.1177/2049463719854483

M3 - Article

JO - British Journal of Pain

JF - British Journal of Pain

SN - 2049-4637

ER -