Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images

R. Ortiz-Ramon, M. D. C. Valdes Hernandez, V. Gonzalez-Castro, S. Makin, P. A. Armitage, B. S. Aribisala, M. E. Bastin, I. J. Deary, J. M. Wardlaw, D. Moratal

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The differential quantification of brain atrophy, white matter hyperintensities (WMH) and stroke lesions is important in studies of stroke and dementia. However, the presence of stroke lesions is usually overlooked by automatic neuroimage processing methods and the-state-of-the-art deep learning schemes, which lack sufficient annotated data. We explore the use of radiomics in identifying whether a brain magnetic resonance imaging (MRI) scan belongs to an individual that had a stroke or not. MATERIALS AND METHODS: We used 1800 3D sets of MRI data from three prospective studies: one of stroke mechanisms and two of cognitive ageing, evaluated 114 textural features in WMH, cerebrospinal fluid, deep grey and normal-appearing white matter, and attempted to classify the scans using a random forest and support vector machine classifiers with and without feature selection. We evaluated the discriminatory power of each feature independently in each population and corrected the result against Type 1 errors. We also evaluated the influence of clinical parameters in the classification results. RESULTS: Subtypes of ischaemic strokes (i.e. lacunar vs. cortical) cannot be discerned using radiomics, but the presence of a stroke-type lesion can be ascertained with accuracies ranging from 0.7 <AUC <0.83. Feature selection, tissue type, stroke subtype and MRI sequence did not seem to determine the classification results. From all clinical variables evaluated, age correlated with the proportion of images classified correctly using either different or the same descriptors (Pearson r = 0.31 and 0.39 respectively, p <0.001). CONCLUSIONS: Texture features in conventionally automatically segmented tissues may help in the identification of the presence of previous stroke lesions on an MRI scan, and should be taken into account in transfer learning strategies of the-state-of-the-art deep learning schemes.
Original languageEnglish
Pages (from-to)12-24
Number of pages13
JournalComput Med Imaging Graph
Volume74
Early online date16 Mar 2019
DOIs
Publication statusPublished - Jun 2019

Fingerprint

Magnetic Resonance Spectroscopy
Stroke
Brain
Magnetic Resonance Imaging
Learning
Lacunar Stroke
Area Under Curve
Atrophy
Cerebrospinal Fluid
Dementia
Prospective Studies
Population
White Matter

Keywords

  • Radiomics
  • Small vessel disease
  • Stroke
  • Texture analysis
  • White matter hyperintensities
  • PERIVASCULAR SPACES
  • SMALL VESSEL DISEASE
  • CLASSIFICATION
  • RADIOMICS

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Health Informatics
  • Radiology Nuclear Medicine and imaging
  • Computer Vision and Pattern Recognition
  • Computer Graphics and Computer-Aided Design

Cite this

Ortiz-Ramon, R., Valdes Hernandez, M. D. C., Gonzalez-Castro, V., Makin, S., Armitage, P. A., Aribisala, B. S., ... Moratal, D. (2019). Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images. Comput Med Imaging Graph, 74, 12-24. https://doi.org/10.1016/j.compmedimag.2019.02.006

Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images. / Ortiz-Ramon, R.; Valdes Hernandez, M. D. C.; Gonzalez-Castro, V.; Makin, S.; Armitage, P. A.; Aribisala, B. S.; Bastin, M. E.; Deary, I. J.; Wardlaw, J. M.; Moratal, D.

In: Comput Med Imaging Graph, Vol. 74, 06.2019, p. 12-24.

Research output: Contribution to journalArticle

Ortiz-Ramon, R, Valdes Hernandez, MDC, Gonzalez-Castro, V, Makin, S, Armitage, PA, Aribisala, BS, Bastin, ME, Deary, IJ, Wardlaw, JM & Moratal, D 2019, 'Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images', Comput Med Imaging Graph, vol. 74, pp. 12-24. https://doi.org/10.1016/j.compmedimag.2019.02.006
Ortiz-Ramon, R. ; Valdes Hernandez, M. D. C. ; Gonzalez-Castro, V. ; Makin, S. ; Armitage, P. A. ; Aribisala, B. S. ; Bastin, M. E. ; Deary, I. J. ; Wardlaw, J. M. ; Moratal, D. / Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images. In: Comput Med Imaging Graph. 2019 ; Vol. 74. pp. 12-24.
@article{4cac150da2ea45928ce44ee4230d85bd,
title = "Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images",
abstract = "BACKGROUND: The differential quantification of brain atrophy, white matter hyperintensities (WMH) and stroke lesions is important in studies of stroke and dementia. However, the presence of stroke lesions is usually overlooked by automatic neuroimage processing methods and the-state-of-the-art deep learning schemes, which lack sufficient annotated data. We explore the use of radiomics in identifying whether a brain magnetic resonance imaging (MRI) scan belongs to an individual that had a stroke or not. MATERIALS AND METHODS: We used 1800 3D sets of MRI data from three prospective studies: one of stroke mechanisms and two of cognitive ageing, evaluated 114 textural features in WMH, cerebrospinal fluid, deep grey and normal-appearing white matter, and attempted to classify the scans using a random forest and support vector machine classifiers with and without feature selection. We evaluated the discriminatory power of each feature independently in each population and corrected the result against Type 1 errors. We also evaluated the influence of clinical parameters in the classification results. RESULTS: Subtypes of ischaemic strokes (i.e. lacunar vs. cortical) cannot be discerned using radiomics, but the presence of a stroke-type lesion can be ascertained with accuracies ranging from 0.7 <AUC <0.83. Feature selection, tissue type, stroke subtype and MRI sequence did not seem to determine the classification results. From all clinical variables evaluated, age correlated with the proportion of images classified correctly using either different or the same descriptors (Pearson r = 0.31 and 0.39 respectively, p <0.001). CONCLUSIONS: Texture features in conventionally automatically segmented tissues may help in the identification of the presence of previous stroke lesions on an MRI scan, and should be taken into account in transfer learning strategies of the-state-of-the-art deep learning schemes.",
keywords = "Radiomics, Small vessel disease, Stroke, Texture analysis, White matter hyperintensities, PERIVASCULAR SPACES, SMALL VESSEL DISEASE, CLASSIFICATION, RADIOMICS",
author = "R. Ortiz-Ramon and {Valdes Hernandez}, {M. D. C.} and V. Gonzalez-Castro and S. Makin and Armitage, {P. A.} and Aribisala, {B. S.} and Bastin, {M. E.} and Deary, {I. J.} and Wardlaw, {J. M.} and D. Moratal",
note = "Study funding This work was funded by the Row Fogo Charitable Trust (MVH, VGC) grant no. BRO-D.FID3668413, and the Wellcome Trust (patient recruitment, scanning, primary study Ref No. 088134/Z/09). The study was conducted independently of the funders who do not hold the data and did not participate in the study design or analyses. The Lothian Birth Cohort 1936 is funded by Age UK (Disconnected Mind grant) and the Medical Research Council (MRC; MR/M01311/1, G1001245, 82800), and the latter supported BSA. IJD was supported by the Centre for Cognitive Ageing and Cognitive Epidemiology, which is funded by the MRC and the Biotechnology and Biological Sciences Research Council (MR/K026992/1). David Moratal acknowledges financial support from the Spanish Ministerio de Econom{\'i}a y Competitividad (MINECO) and FEDER funds under Grant BFU2015-64380-C2-2-R, and from the Conselleria d'Educaci{\'o}, Investigaci{\'o}, Cultura i Esport, Generalitat Valenciana (grants AEST/2017/013 and AEST/2018/021). Rafael Ortiz-Ram{\'o}n was supported by grant ACIF/2015/078 and grant BEFPI/2017/004 from the Conselleria d’Educaci{\'o}, Investigaci{\'o}, Cultura i Esport of the Valencian Community (Spain).",
year = "2019",
month = "6",
doi = "10.1016/j.compmedimag.2019.02.006",
language = "English",
volume = "74",
pages = "12--24",
journal = "Comput Med Imaging Graph",
issn = "1879-0771",
publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images

AU - Ortiz-Ramon, R.

AU - Valdes Hernandez, M. D. C.

AU - Gonzalez-Castro, V.

AU - Makin, S.

AU - Armitage, P. A.

AU - Aribisala, B. S.

AU - Bastin, M. E.

AU - Deary, I. J.

AU - Wardlaw, J. M.

AU - Moratal, D.

N1 - Study funding This work was funded by the Row Fogo Charitable Trust (MVH, VGC) grant no. BRO-D.FID3668413, and the Wellcome Trust (patient recruitment, scanning, primary study Ref No. 088134/Z/09). The study was conducted independently of the funders who do not hold the data and did not participate in the study design or analyses. The Lothian Birth Cohort 1936 is funded by Age UK (Disconnected Mind grant) and the Medical Research Council (MRC; MR/M01311/1, G1001245, 82800), and the latter supported BSA. IJD was supported by the Centre for Cognitive Ageing and Cognitive Epidemiology, which is funded by the MRC and the Biotechnology and Biological Sciences Research Council (MR/K026992/1). David Moratal acknowledges financial support from the Spanish Ministerio de Economía y Competitividad (MINECO) and FEDER funds under Grant BFU2015-64380-C2-2-R, and from the Conselleria d'Educació, Investigació, Cultura i Esport, Generalitat Valenciana (grants AEST/2017/013 and AEST/2018/021). Rafael Ortiz-Ramón was supported by grant ACIF/2015/078 and grant BEFPI/2017/004 from the Conselleria d’Educació, Investigació, Cultura i Esport of the Valencian Community (Spain).

PY - 2019/6

Y1 - 2019/6

N2 - BACKGROUND: The differential quantification of brain atrophy, white matter hyperintensities (WMH) and stroke lesions is important in studies of stroke and dementia. However, the presence of stroke lesions is usually overlooked by automatic neuroimage processing methods and the-state-of-the-art deep learning schemes, which lack sufficient annotated data. We explore the use of radiomics in identifying whether a brain magnetic resonance imaging (MRI) scan belongs to an individual that had a stroke or not. MATERIALS AND METHODS: We used 1800 3D sets of MRI data from three prospective studies: one of stroke mechanisms and two of cognitive ageing, evaluated 114 textural features in WMH, cerebrospinal fluid, deep grey and normal-appearing white matter, and attempted to classify the scans using a random forest and support vector machine classifiers with and without feature selection. We evaluated the discriminatory power of each feature independently in each population and corrected the result against Type 1 errors. We also evaluated the influence of clinical parameters in the classification results. RESULTS: Subtypes of ischaemic strokes (i.e. lacunar vs. cortical) cannot be discerned using radiomics, but the presence of a stroke-type lesion can be ascertained with accuracies ranging from 0.7 <AUC <0.83. Feature selection, tissue type, stroke subtype and MRI sequence did not seem to determine the classification results. From all clinical variables evaluated, age correlated with the proportion of images classified correctly using either different or the same descriptors (Pearson r = 0.31 and 0.39 respectively, p <0.001). CONCLUSIONS: Texture features in conventionally automatically segmented tissues may help in the identification of the presence of previous stroke lesions on an MRI scan, and should be taken into account in transfer learning strategies of the-state-of-the-art deep learning schemes.

AB - BACKGROUND: The differential quantification of brain atrophy, white matter hyperintensities (WMH) and stroke lesions is important in studies of stroke and dementia. However, the presence of stroke lesions is usually overlooked by automatic neuroimage processing methods and the-state-of-the-art deep learning schemes, which lack sufficient annotated data. We explore the use of radiomics in identifying whether a brain magnetic resonance imaging (MRI) scan belongs to an individual that had a stroke or not. MATERIALS AND METHODS: We used 1800 3D sets of MRI data from three prospective studies: one of stroke mechanisms and two of cognitive ageing, evaluated 114 textural features in WMH, cerebrospinal fluid, deep grey and normal-appearing white matter, and attempted to classify the scans using a random forest and support vector machine classifiers with and without feature selection. We evaluated the discriminatory power of each feature independently in each population and corrected the result against Type 1 errors. We also evaluated the influence of clinical parameters in the classification results. RESULTS: Subtypes of ischaemic strokes (i.e. lacunar vs. cortical) cannot be discerned using radiomics, but the presence of a stroke-type lesion can be ascertained with accuracies ranging from 0.7 <AUC <0.83. Feature selection, tissue type, stroke subtype and MRI sequence did not seem to determine the classification results. From all clinical variables evaluated, age correlated with the proportion of images classified correctly using either different or the same descriptors (Pearson r = 0.31 and 0.39 respectively, p <0.001). CONCLUSIONS: Texture features in conventionally automatically segmented tissues may help in the identification of the presence of previous stroke lesions on an MRI scan, and should be taken into account in transfer learning strategies of the-state-of-the-art deep learning schemes.

KW - Radiomics

KW - Small vessel disease

KW - Stroke

KW - Texture analysis

KW - White matter hyperintensities

KW - PERIVASCULAR SPACES

KW - SMALL VESSEL DISEASE

KW - CLASSIFICATION

KW - RADIOMICS

UR - http://www.scopus.com/inward/record.url?scp=85063342062&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/identification-presence-ischaemic-stroke-lesions-means-texture-analysis-brain-magnetic-resonance-ima

U2 - 10.1016/j.compmedimag.2019.02.006

DO - 10.1016/j.compmedimag.2019.02.006

M3 - Article

VL - 74

SP - 12

EP - 24

JO - Comput Med Imaging Graph

JF - Comput Med Imaging Graph

SN - 1879-0771

ER -