Idiopathic chronic cough and organ-specific autoimmune diseases: a case-control study

A. C. Murphy, S. S. Birring, Jane Elizabeth Scullion, C,E. Brightling, M. Browning, I. D. Pavord

    Research output: Contribution to journalArticle

    48 Citations (Scopus)

    Abstract

    The marked female predominance in cases of idiopathic chronic cough and its association with mild chronic lymphocytic airway inflammation suggests an underlying autoimmune process. We set out to test the hypothesis that idiopathic chronic cough is associated with other organ-specific autoimmune diseases in a case-control study. Twenty-two patients with idiopathic chronic cough and 65 community-matched controls for age and sex who responded to a self-administered questionnaire were asked about the presence of autoimmune disease, other medical problems and drug history. All subjects were invited to have a blood test for an autoimmune screen. Thirteen out of 22 (59%) patients with idiopathic chronic cough and eight out of 65 (12%) age- and sex-matched controls reported organ-specific autoimmune disease (odds ratio 8.8; 95% confidence interval 2.4-31.8, P<0.001). Organ-specific autoantibodies were present in a significantly higher proportion of cases than controls (40% vs. 13%; P = 0.047). These findings suggest a relationship between idiopathic chronic cough and organ-specific autoimmunity. (C) 2003 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)242-246
    Number of pages4
    JournalRespiratory Medicine
    Volume98
    DOIs
    Publication statusPublished - 2004

    Keywords

    • chronic cough
    • idiopathic chronic cough
    • autoimmune disease
    • CELIAC-DISEASE
    • REFLEX

    Cite this

    Murphy, A. C., Birring, S. S., Scullion, J. E., Brightling, CE., Browning, M., & Pavord, I. D. (2004). Idiopathic chronic cough and organ-specific autoimmune diseases: a case-control study. Respiratory Medicine, 98, 242-246. https://doi.org/10.1016/j.rmed.2003.10.005

    Idiopathic chronic cough and organ-specific autoimmune diseases: a case-control study. / Murphy, A. C.; Birring, S. S.; Scullion, Jane Elizabeth; Brightling, C,E.; Browning, M.; Pavord, I. D.

    In: Respiratory Medicine, Vol. 98, 2004, p. 242-246.

    Research output: Contribution to journalArticle

    Murphy, AC, Birring, SS, Scullion, JE, Brightling, CE, Browning, M & Pavord, ID 2004, 'Idiopathic chronic cough and organ-specific autoimmune diseases: a case-control study', Respiratory Medicine, vol. 98, pp. 242-246. https://doi.org/10.1016/j.rmed.2003.10.005
    Murphy, A. C. ; Birring, S. S. ; Scullion, Jane Elizabeth ; Brightling, C,E. ; Browning, M. ; Pavord, I. D. / Idiopathic chronic cough and organ-specific autoimmune diseases: a case-control study. In: Respiratory Medicine. 2004 ; Vol. 98. pp. 242-246.
    @article{d0c7c1163f114c61af04b4d23e18df04,
    title = "Idiopathic chronic cough and organ-specific autoimmune diseases: a case-control study",
    abstract = "The marked female predominance in cases of idiopathic chronic cough and its association with mild chronic lymphocytic airway inflammation suggests an underlying autoimmune process. We set out to test the hypothesis that idiopathic chronic cough is associated with other organ-specific autoimmune diseases in a case-control study. Twenty-two patients with idiopathic chronic cough and 65 community-matched controls for age and sex who responded to a self-administered questionnaire were asked about the presence of autoimmune disease, other medical problems and drug history. All subjects were invited to have a blood test for an autoimmune screen. Thirteen out of 22 (59{\%}) patients with idiopathic chronic cough and eight out of 65 (12{\%}) age- and sex-matched controls reported organ-specific autoimmune disease (odds ratio 8.8; 95{\%} confidence interval 2.4-31.8, P<0.001). Organ-specific autoantibodies were present in a significantly higher proportion of cases than controls (40{\%} vs. 13{\%}; P = 0.047). These findings suggest a relationship between idiopathic chronic cough and organ-specific autoimmunity. (C) 2003 Elsevier Ltd. All rights reserved.",
    keywords = "chronic cough, idiopathic chronic cough, autoimmune disease, CELIAC-DISEASE, REFLEX",
    author = "Murphy, {A. C.} and Birring, {S. S.} and Scullion, {Jane Elizabeth} and C,E. Brightling and M. Browning and Pavord, {I. D.}",
    year = "2004",
    doi = "10.1016/j.rmed.2003.10.005",
    language = "English",
    volume = "98",
    pages = "242--246",
    journal = "Respiratory Medicine",
    issn = "0954-6111",
    publisher = "Elsevier",

    }

    TY - JOUR

    T1 - Idiopathic chronic cough and organ-specific autoimmune diseases: a case-control study

    AU - Murphy, A. C.

    AU - Birring, S. S.

    AU - Scullion, Jane Elizabeth

    AU - Brightling, C,E.

    AU - Browning, M.

    AU - Pavord, I. D.

    PY - 2004

    Y1 - 2004

    N2 - The marked female predominance in cases of idiopathic chronic cough and its association with mild chronic lymphocytic airway inflammation suggests an underlying autoimmune process. We set out to test the hypothesis that idiopathic chronic cough is associated with other organ-specific autoimmune diseases in a case-control study. Twenty-two patients with idiopathic chronic cough and 65 community-matched controls for age and sex who responded to a self-administered questionnaire were asked about the presence of autoimmune disease, other medical problems and drug history. All subjects were invited to have a blood test for an autoimmune screen. Thirteen out of 22 (59%) patients with idiopathic chronic cough and eight out of 65 (12%) age- and sex-matched controls reported organ-specific autoimmune disease (odds ratio 8.8; 95% confidence interval 2.4-31.8, P<0.001). Organ-specific autoantibodies were present in a significantly higher proportion of cases than controls (40% vs. 13%; P = 0.047). These findings suggest a relationship between idiopathic chronic cough and organ-specific autoimmunity. (C) 2003 Elsevier Ltd. All rights reserved.

    AB - The marked female predominance in cases of idiopathic chronic cough and its association with mild chronic lymphocytic airway inflammation suggests an underlying autoimmune process. We set out to test the hypothesis that idiopathic chronic cough is associated with other organ-specific autoimmune diseases in a case-control study. Twenty-two patients with idiopathic chronic cough and 65 community-matched controls for age and sex who responded to a self-administered questionnaire were asked about the presence of autoimmune disease, other medical problems and drug history. All subjects were invited to have a blood test for an autoimmune screen. Thirteen out of 22 (59%) patients with idiopathic chronic cough and eight out of 65 (12%) age- and sex-matched controls reported organ-specific autoimmune disease (odds ratio 8.8; 95% confidence interval 2.4-31.8, P<0.001). Organ-specific autoantibodies were present in a significantly higher proportion of cases than controls (40% vs. 13%; P = 0.047). These findings suggest a relationship between idiopathic chronic cough and organ-specific autoimmunity. (C) 2003 Elsevier Ltd. All rights reserved.

    KW - chronic cough

    KW - idiopathic chronic cough

    KW - autoimmune disease

    KW - CELIAC-DISEASE

    KW - REFLEX

    U2 - 10.1016/j.rmed.2003.10.005

    DO - 10.1016/j.rmed.2003.10.005

    M3 - Article

    VL - 98

    SP - 242

    EP - 246

    JO - Respiratory Medicine

    JF - Respiratory Medicine

    SN - 0954-6111

    ER -