If phosphatases go up, memory goes down

Research output: Contribution to journalLiterature review

28 Citations (Scopus)

Abstract

Previous work has provided conclusive support for a role of various protein kinases in processes underlying learning and memory formation. While these processes are not yet established in full detail, it is interesting to entertain the idea of protein phosphatases being involved in such mechanisms as well. Recent advances in this respect have provided preliminary support of this view. From the pharmacological as well as the transgenic analysis, it appears that especially the calcineurin/inhibitor-1 cascade plays an important role in the transition of intermediate-term into long-term memory formation.

Original languageEnglish
Pages (from-to)549-553
Number of pages5
JournalCellular and Molecular Life Sciences
Volume55
Publication statusPublished - 1999

Keywords

  • hippocampus
  • synaptic plasticity
  • memory formation
  • protein kinase A
  • protein phosphatase 1 and 2A
  • calcineurin
  • PROTEIN-KINASE-C
  • LONG-TERM POTENTIATION
  • HIPPOCAMPAL CA1 REGION
  • CYCLOSPORINE-A
  • OKADAIC ACID
  • INDUCED LTP
  • CALCINEURIN
  • RAT
  • DEPHOSPHORYLATION
  • DEPRESSION

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