Abstract
Previous work has provided conclusive support for a role of various protein kinases in processes underlying learning and memory formation. While these processes are not yet established in full detail, it is interesting to entertain the idea of protein phosphatases being involved in such mechanisms as well. Recent advances in this respect have provided preliminary support of this view. From the pharmacological as well as the transgenic analysis, it appears that especially the calcineurin/inhibitor-1 cascade plays an important role in the transition of intermediate-term into long-term memory formation.
| Original language | English |
|---|---|
| Pages (from-to) | 549-553 |
| Number of pages | 5 |
| Journal | Cellular and Molecular Life Sciences |
| Volume | 55 |
| Publication status | Published - 1999 |
Keywords
- hippocampus
- synaptic plasticity
- memory formation
- protein kinase A
- protein phosphatase 1 and 2A
- calcineurin
- PROTEIN-KINASE-C
- LONG-TERM POTENTIATION
- HIPPOCAMPAL CA1 REGION
- CYCLOSPORINE-A
- OKADAIC ACID
- INDUCED LTP
- CALCINEURIN
- RAT
- DEPHOSPHORYLATION
- DEPRESSION