IL-17 and neutrophils: unexpected players in the type 2 immune response.

Judith E Allen; Tara Sutherland; Dominik Ruckerl

doi:10.1016/j.coi.2015.03.001

IL-17 and neutrophils: unexpected players in the type 2 immune response.

Judith E Allen, Tara Sutherland, Dominik Ruckerl

Medical Sciences

University of Edinburgh

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

The study of immunity to helminth infection has been central to understanding the function of type 2 cytokines and their targets. Although type 2 cytokines are considered anti-inflammatory and promote tissue repair, they also contribute to allergy and fibrosis. Here, we utilise data from helminth infection models, to illustrate that IL-17 and neutrophils, typically associated with pro-inflammatory responses, are intimately linked with type 2 immunity. Neutrophils work with IL-4Rα-activated macrophages to control incoming larvae but this comes at a cost of enhanced tissue damage. Chitinase like proteins (CLPs) bridge these diverse outcomes, inducing both protective IL-17 and reparative Th2 responses. Dysregulation of CLPs, IL-17 and neutrophils likely contribute to disease severity and pathology associated with type 2 immunity.

Original language	English
Pages (from-to)	99-106
Journal	Current Opinion in Immunology
Volume	34
DOIs	https://doi.org/10.1016/j.coi.2015.03.001
Publication status	Published - 1 Jun 2015

Bibliographical note

095831MA, Wellcome Trust, United Kingdom
MR/J001929/1, Medical Research Council, United Kingdom
MR/K01207X/1, Medical Research Council, United Kingdom

Acknowledgements
The authors are supported by funding from the Medical Research Council UK (MR/J001929/1, MR/K01207X/1) and the Wellcome Trust funded Centre for Immunity, Infection and Evolution (095831MA).

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title = "IL-17 and neutrophils: unexpected players in the type 2 immune response.",

abstract = "The study of immunity to helminth infection has been central to understanding the function of type 2 cytokines and their targets. Although type 2 cytokines are considered anti-inflammatory and promote tissue repair, they also contribute to allergy and fibrosis. Here, we utilise data from helminth infection models, to illustrate that IL-17 and neutrophils, typically associated with pro-inflammatory responses, are intimately linked with type 2 immunity. Neutrophils work with IL-4Rα-activated macrophages to control incoming larvae but this comes at a cost of enhanced tissue damage. Chitinase like proteins (CLPs) bridge these diverse outcomes, inducing both protective IL-17 and reparative Th2 responses. Dysregulation of CLPs, IL-17 and neutrophils likely contribute to disease severity and pathology associated with type 2 immunity.",

author = "Allen, {Judith E} and Tara Sutherland and Dominik Ruckerl",

note = "095831MA, Wellcome Trust, United Kingdom MR/J001929/1, Medical Research Council, United Kingdom MR/K01207X/1, Medical Research Council, United Kingdom Acknowledgements The authors are supported by funding from the Medical Research Council UK (MR/J001929/1, MR/K01207X/1) and the Wellcome Trust funded Centre for Immunity, Infection and Evolution (095831MA).",

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AU - Sutherland, Tara

AU - Ruckerl, Dominik

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Y1 - 2015/6/1

N2 - The study of immunity to helminth infection has been central to understanding the function of type 2 cytokines and their targets. Although type 2 cytokines are considered anti-inflammatory and promote tissue repair, they also contribute to allergy and fibrosis. Here, we utilise data from helminth infection models, to illustrate that IL-17 and neutrophils, typically associated with pro-inflammatory responses, are intimately linked with type 2 immunity. Neutrophils work with IL-4Rα-activated macrophages to control incoming larvae but this comes at a cost of enhanced tissue damage. Chitinase like proteins (CLPs) bridge these diverse outcomes, inducing both protective IL-17 and reparative Th2 responses. Dysregulation of CLPs, IL-17 and neutrophils likely contribute to disease severity and pathology associated with type 2 immunity.

AB - The study of immunity to helminth infection has been central to understanding the function of type 2 cytokines and their targets. Although type 2 cytokines are considered anti-inflammatory and promote tissue repair, they also contribute to allergy and fibrosis. Here, we utilise data from helminth infection models, to illustrate that IL-17 and neutrophils, typically associated with pro-inflammatory responses, are intimately linked with type 2 immunity. Neutrophils work with IL-4Rα-activated macrophages to control incoming larvae but this comes at a cost of enhanced tissue damage. Chitinase like proteins (CLPs) bridge these diverse outcomes, inducing both protective IL-17 and reparative Th2 responses. Dysregulation of CLPs, IL-17 and neutrophils likely contribute to disease severity and pathology associated with type 2 immunity.

U2 - 10.1016/j.coi.2015.03.001

DO - 10.1016/j.coi.2015.03.001

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JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

ER -

IL-17 and neutrophils: unexpected players in the type 2 immune response.

Abstract

Bibliographical note

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