IL-6 promotes CD4+ T-cell and B-cell activation during Plasmodium infection

Ismail Sebina, Lily Georgina Fogg, Kylie James, Megan Soon, Jasmin Akter, Bryce Thomas, Geoffrey Hill, Christian Engwerda, Ashraful Haque (Corresponding Author)

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Humoral immunity develops in the spleen during blood-stage Plasmodium infection. This elicits parasite-specific IgM and IgG, which control parasites and protect against malaria. Studies in mice have elucidated cells and molecules driving humoral immunity to Plasmodium, including CD4+ T cells, B cells, interleukin (IL)-21 and ICOS. IL-6, a cytokine readily detected in Plasmodium-infected mice and humans, is recognized in other systems as a driver of humoral immunity. Here, we examined the effect of infection-induced IL-6 on humoral immunity to Plasmodium. Using P. chabaudi chabaudi AS (PcAS) infection of wild-type and IL-6−/− mice, we found that IL-6 helped to control parasites during primary infection. IL-6 promoted early production of parasite-specific IgM but not IgG. Notably, splenic CD138+ plasmablast development was more dependent on IL-6 than germinal centre (GC) B-cell differentiation. IL-6 also promoted ICOS expression by CD4+ T cells, as well as their localization close to splenic B cells, but was not required for early Tfh-cell development. Finally, IL-6 promoted parasite control, IgM and IgG production, GC B-cell development and ICOS expression by Tfh cells in a second model, Py17XNL infection. IL-6 promotes CD4+ T-cell activation and B-cell responses during blood-stage Plasmodium infection, which encourages parasite-specific antibody production.
Original languageEnglish
Article numbere12455
JournalParasite Immunology
Volume39
Issue number10
Early online date17 Aug 2017
DOIs
Publication statusPublished - Oct 2017

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Malaria
Interleukin-6
B-Lymphocytes
T-Lymphocytes
Humoral Immunity
Communicable Disease Control
Plasmodium
Immunoglobulin M
Parasites
Germinal Center
Immunoglobulin G
Infection
Antibody Formation
Cell Differentiation
Spleen
Cytokines

Keywords

  • animal model
  • B lymphocyte
  • CD4 T lymphocyte
  • costimulatory molecules
  • cytokine
  • humoral immunity
  • malaria

Cite this

Sebina, I., Fogg, L. G., James, K., Soon, M., Akter, J., Thomas, B., ... Haque, A. (2017). IL-6 promotes CD4+ T-cell and B-cell activation during Plasmodium infection. Parasite Immunology, 39(10), [e12455]. https://doi.org/10.1111/pim.12455

IL-6 promotes CD4+ T-cell and B-cell activation during Plasmodium infection. / Sebina, Ismail; Fogg, Lily Georgina; James, Kylie; Soon, Megan; Akter, Jasmin; Thomas, Bryce; Hill, Geoffrey; Engwerda, Christian; Haque, Ashraful (Corresponding Author).

In: Parasite Immunology, Vol. 39, No. 10, e12455, 10.2017.

Research output: Contribution to journalArticle

Sebina, I, Fogg, LG, James, K, Soon, M, Akter, J, Thomas, B, Hill, G, Engwerda, C & Haque, A 2017, 'IL-6 promotes CD4+ T-cell and B-cell activation during Plasmodium infection', Parasite Immunology, vol. 39, no. 10, e12455. https://doi.org/10.1111/pim.12455
Sebina I, Fogg LG, James K, Soon M, Akter J, Thomas B et al. IL-6 promotes CD4+ T-cell and B-cell activation during Plasmodium infection. Parasite Immunology. 2017 Oct;39(10). e12455. https://doi.org/10.1111/pim.12455
Sebina, Ismail ; Fogg, Lily Georgina ; James, Kylie ; Soon, Megan ; Akter, Jasmin ; Thomas, Bryce ; Hill, Geoffrey ; Engwerda, Christian ; Haque, Ashraful. / IL-6 promotes CD4+ T-cell and B-cell activation during Plasmodium infection. In: Parasite Immunology. 2017 ; Vol. 39, No. 10.
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AU - Thomas, Bryce

AU - Hill, Geoffrey

AU - Engwerda, Christian

AU - Haque, Ashraful

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