Imaging tumour hypoxia with Positron Emission Tomography

I N Fleming, R Manavaki, P J Blower, C West, K J Williams, A L Harris, J Domarkas, S Lord, C Baldry, F J Gilbert

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Abstract

Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. Given its prominent role in oncology, accurate detection of hypoxia is important, as it impacts on prognosis and could influence treatment planning. A variety of approaches have been explored over the years for detecting and monitoring changes in hypoxia in tumours, including biological markers and noninvasive imaging techniques. Positron emission tomography (PET) is the preferred method for imaging tumour hypoxia due to its high specificity and sensitivity to probe physiological processes in vivo, as well as the ability to provide information about intracellular oxygenation levels. This review provides an overview of imaging hypoxia with PET, with an emphasis on the advantages and limitations of the currently available hypoxia radiotracers.
Original languageEnglish
Pages (from-to)238-250
Number of pages13
JournalBritish Journal of Cancer
Volume112
Issue number2
Early online date16 Dec 2014
DOIs
Publication statusPublished - 20 Jan 2015

Keywords

  • positron emission tomography (PET)
  • imaging
  • oncology
  • cancer
  • hypoxia
  • radiotracer

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  • Cite this

    Fleming, I. N., Manavaki, R., Blower, P. J., West, C., Williams, K. J., Harris, A. L., Domarkas, J., Lord, S., Baldry, C., & Gilbert, F. J. (2015). Imaging tumour hypoxia with Positron Emission Tomography. British Journal of Cancer, 112(2), 238-250. https://doi.org/10.1038/bjc.2014.610