Imaging tumour hypoxia with Positron Emission Tomography

I N Fleming; R Manavaki; P J Blower; C West; K J  Williams; A L Harris; J Domarkas; S Lord; C Baldry; F J Gilbert

doi:10.1038/bjc.2014.610

Imaging tumour hypoxia with Positron Emission Tomography

I N Fleming, R Manavaki, P J Blower, C West, K J Williams, A L Harris, J Domarkas, S Lord, C Baldry, F J Gilbert

Research output: Contribution to journal › Literature review › peer-review

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Abstract

Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. Given its prominent role in oncology, accurate detection of hypoxia is important, as it impacts on prognosis and could influence treatment planning. A variety of approaches have been explored over the years for detecting and monitoring changes in hypoxia in tumours, including biological markers and noninvasive imaging techniques. Positron emission tomography (PET) is the preferred method for imaging tumour hypoxia due to its high specificity and sensitivity to probe physiological processes in vivo, as well as the ability to provide information about intracellular oxygenation levels. This review provides an overview of imaging hypoxia with PET, with an emphasis on the advantages and limitations of the currently available hypoxia radiotracers.

Original language	English
Pages (from-to)	238-250
Number of pages	13
Journal	British Journal of Cancer
Volume	112
Issue number	2
Early online date	16 Dec 2014
DOIs	https://doi.org/10.1038/bjc.2014.610
Publication status	Published - 20 Jan 2015

Bibliographical note

ACKNOWLEDGEMENTS
Cancer Research UK (CRUK) funded the National Cancer Research Institute (NCRI) PET Research Working party to organise a meeting to discuss imaging cancer with hypoxia tracers and Positron Emission Tomography. IF was funded by CRUK and is also supported by the Chief Scientific Office. ALH is supported by CRUK and the Breast Cancer Research Foundation. RM is funded by NIHR Cambridge Biomedical Research Centre. We would also like to thank Professors Tim Eisen and Duncan Jodrell, University of Cambridge, UK and Dr Anastasia Chalkidou, King’s
College London, UK for providing the 18F-FMISO and 64CuATSM images illustrated in this review

Keywords

positron emission tomography (PET)
imaging
oncology
cancer
hypoxia
radiotracer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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BJC2014 - Fleming
Twelve months after publication in British Journal of Cancer, the Contribution, as published on the BJC website, will be offered for reuse under the terms of the Creative Commons Attribution-NonCommercial-Share-Alike 3.0 licence, subject to the conditions listed at http://creativecommons.org/licences/by-nc-sa/3.0/
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Cite this

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abstract = "Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. Given its prominent role in oncology, accurate detection of hypoxia is important, as it impacts on prognosis and could influence treatment planning. A variety of approaches have been explored over the years for detecting and monitoring changes in hypoxia in tumours, including biological markers and noninvasive imaging techniques. Positron emission tomography (PET) is the preferred method for imaging tumour hypoxia due to its high specificity and sensitivity to probe physiological processes in vivo, as well as the ability to provide information about intracellular oxygenation levels. This review provides an overview of imaging hypoxia with PET, with an emphasis on the advantages and limitations of the currently available hypoxia radiotracers.",

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note = "ACKNOWLEDGEMENTS Cancer Research UK (CRUK) funded the National Cancer Research Institute (NCRI) PET Research Working party to organise a meeting to discuss imaging cancer with hypoxia tracers and Positron Emission Tomography. IF was funded by CRUK and is also supported by the Chief Scientific Office. ALH is supported by CRUK and the Breast Cancer Research Foundation. RM is funded by NIHR Cambridge Biomedical Research Centre. We would also like to thank Professors Tim Eisen and Duncan Jodrell, University of Cambridge, UK and Dr Anastasia Chalkidou, King{\textquoteright}s College London, UK for providing the 18F-FMISO and 64CuATSM images illustrated in this review",

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AU - Fleming, I N

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AU - Williams, K J

AU - Harris, A L

AU - Domarkas, J

AU - Lord, S

AU - Baldry, C

AU - Gilbert, F J

N1 - ACKNOWLEDGEMENTS Cancer Research UK (CRUK) funded the National Cancer Research Institute (NCRI) PET Research Working party to organise a meeting to discuss imaging cancer with hypoxia tracers and Positron Emission Tomography. IF was funded by CRUK and is also supported by the Chief Scientific Office. ALH is supported by CRUK and the Breast Cancer Research Foundation. RM is funded by NIHR Cambridge Biomedical Research Centre. We would also like to thank Professors Tim Eisen and Duncan Jodrell, University of Cambridge, UK and Dr Anastasia Chalkidou, King’s College London, UK for providing the 18F-FMISO and 64CuATSM images illustrated in this review

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N2 - Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. Given its prominent role in oncology, accurate detection of hypoxia is important, as it impacts on prognosis and could influence treatment planning. A variety of approaches have been explored over the years for detecting and monitoring changes in hypoxia in tumours, including biological markers and noninvasive imaging techniques. Positron emission tomography (PET) is the preferred method for imaging tumour hypoxia due to its high specificity and sensitivity to probe physiological processes in vivo, as well as the ability to provide information about intracellular oxygenation levels. This review provides an overview of imaging hypoxia with PET, with an emphasis on the advantages and limitations of the currently available hypoxia radiotracers.

AB - Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. Given its prominent role in oncology, accurate detection of hypoxia is important, as it impacts on prognosis and could influence treatment planning. A variety of approaches have been explored over the years for detecting and monitoring changes in hypoxia in tumours, including biological markers and noninvasive imaging techniques. Positron emission tomography (PET) is the preferred method for imaging tumour hypoxia due to its high specificity and sensitivity to probe physiological processes in vivo, as well as the ability to provide information about intracellular oxygenation levels. This review provides an overview of imaging hypoxia with PET, with an emphasis on the advantages and limitations of the currently available hypoxia radiotracers.

KW - positron emission tomography (PET)

KW - imaging

KW - oncology

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KW - hypoxia

KW - radiotracer

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DO - 10.1038/bjc.2014.610

M3 - Literature review

SN - 0007-0920

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SP - 238

EP - 250

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 2

ER -

Imaging tumour hypoxia with Positron Emission Tomography

Abstract

Bibliographical note

Keywords

UN SDGs

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