Immediate or delayed radiotherapy in advanced non-small-cell lung cancer (NSCLC)? Data from a prospective randomised study.

S. Sundstrøm, R. Bremnes, P. Brunsvig, U. Aasebø, O. Klepp, Peter Fayers, S. Kaasa, Norwegian Lung Canc Study Grp

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Abstract

Background and purpose: To compare the course of symptoms and health-related quality-of-life (HRQOL) after immediate thoracic radiotherapy (TRT) between symptomatic (S) and non-symptomatic (NS) patients with advanced NSCLC.

Patients and methods: 407 stage III/IV patients were initially treated with immediate TRT within a randomised phase III trial comparing different fractionation schedules. At inclusion, patients were prospectively stratified according to presence (S) or absence (NS) of tumour-related chest/airway symptoms to facilitate comparison between these groups. The EORTC QLQ-C30 and LC-13 were used for symptom and HRQOL assessments at baseline and at regular intervals up to 1 year (N = 395).

Results: NS patients had significantly more favourable baseline characteristics when compared to S patients with a median survival of 11.8 versus 6.0 months (P < 0.0001), respectively. At baseline, S patients demonstrated HRQOL scores inferior to those of NS patients (P < 0.01) for most scales. Until week 14, NS patients developed more symptoms while S patients experienced symptom relief in most scales. After week 14, no significant differences could be observed between the groups.

Conclusion: This study indicates that immediate TRT, given to patients with minimal/none chest symptoms, does not prevent development of disease-related symptoms and diminished HRQOL. A wait-and-see policy appears to be acceptable. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalRadiotherapy and Oncology
Volume75
Issue number2
Early online date11 May 2005
DOIs
Publication statusPublished - May 2005

Keywords

  • palliative radiotherapy
  • lung cancer
  • NSCLC
  • immediate treatment
  • quality-of-life
  • QUALITY-OF-LIFE
  • PALLIATIVE THORACIC RADIOTHERAPY
  • QUESTIONNAIRE QLQ-C30
  • ASYMPTOMATIC PATIENTS
  • INOPERABLE CARCINOMA
  • CLINICAL-TRIALS
  • SCORES
  • YES
  • NO

Cite this

Sundstrøm, S., Bremnes, R., Brunsvig, P., Aasebø, U., Klepp, O., Fayers, P., Kaasa, S., & Norwegian Lung Canc Study Grp (2005). Immediate or delayed radiotherapy in advanced non-small-cell lung cancer (NSCLC)? Data from a prospective randomised study. Radiotherapy and Oncology, 75(2), 141-148. https://doi.org/10.1016/j.radonc.2005.03.028