Immune privilege or privileged immunity?

John Vincent Forrester, Heping Xu, T. Lambe, R. J. Cornall

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Immune privilege is a concept that has come of age. Where previously it was considered to be a passive phenomenon restricted to certain specialized tissues, it is now viewed as comprising several mechanisms, both active and passive, shared in many aspects with emerging notions of the mechanisms of peripheral tolerance. The relative degrees of immune privilege vary from tissue to tissue depending on the number and strength of each of the mechanisms contained in that tissue. Immune privilege can be generated in non-privileged sites such as the skin and allografts, and is a property of the tissue itself. We therefore propose that, in addition to canonical central and peripheral tolerance mechanisms, there is a third route whereby the organism promotes self-antigen non-reactivity centered on the specific properties of each tissue and varying accordingly (relative degrees of immune privilege). This third mechanism of inducing immunological tolerance, as it is a local tissue phenomenon, might have particular therapeutic significance, for instance in devising strategies for induction of immunity to tumors by disrupting immune privilege or in preventing graft rejection by promoting immune privilege.

Original languageEnglish
Pages (from-to)372-381
Number of pages9
JournalMucosal Immunology
Volume1
Issue number5
DOIs
Publication statusPublished - Aug 2008

Keywords

  • regulatory T-cells
  • blood-brain-barrier
  • experimental autoimmune uveitis
  • long-term acceptance
  • draining lymph-node
  • human hair follicle
  • FAS ligand
  • anterior-chamber
  • dendritic cells
  • in-vivo

Cite this

Forrester, J. V., Xu, H., Lambe, T., & Cornall, R. J. (2008). Immune privilege or privileged immunity? Mucosal Immunology, 1(5), 372-381. https://doi.org/10.1038/mi.2008.27

Immune privilege or privileged immunity? / Forrester, John Vincent; Xu, Heping; Lambe, T.; Cornall, R. J.

In: Mucosal Immunology, Vol. 1, No. 5, 08.2008, p. 372-381.

Research output: Contribution to journalArticle

Forrester, JV, Xu, H, Lambe, T & Cornall, RJ 2008, 'Immune privilege or privileged immunity?', Mucosal Immunology, vol. 1, no. 5, pp. 372-381. https://doi.org/10.1038/mi.2008.27
Forrester JV, Xu H, Lambe T, Cornall RJ. Immune privilege or privileged immunity? Mucosal Immunology. 2008 Aug;1(5):372-381. https://doi.org/10.1038/mi.2008.27
Forrester, John Vincent ; Xu, Heping ; Lambe, T. ; Cornall, R. J. / Immune privilege or privileged immunity?. In: Mucosal Immunology. 2008 ; Vol. 1, No. 5. pp. 372-381.
@article{d8edde70427749a7b51f4580450bffc0,
title = "Immune privilege or privileged immunity?",
abstract = "Immune privilege is a concept that has come of age. Where previously it was considered to be a passive phenomenon restricted to certain specialized tissues, it is now viewed as comprising several mechanisms, both active and passive, shared in many aspects with emerging notions of the mechanisms of peripheral tolerance. The relative degrees of immune privilege vary from tissue to tissue depending on the number and strength of each of the mechanisms contained in that tissue. Immune privilege can be generated in non-privileged sites such as the skin and allografts, and is a property of the tissue itself. We therefore propose that, in addition to canonical central and peripheral tolerance mechanisms, there is a third route whereby the organism promotes self-antigen non-reactivity centered on the specific properties of each tissue and varying accordingly (relative degrees of immune privilege). This third mechanism of inducing immunological tolerance, as it is a local tissue phenomenon, might have particular therapeutic significance, for instance in devising strategies for induction of immunity to tumors by disrupting immune privilege or in preventing graft rejection by promoting immune privilege.",
keywords = "regulatory T-cells, blood-brain-barrier, experimental autoimmune uveitis, long-term acceptance, draining lymph-node, human hair follicle, FAS ligand, anterior-chamber, dendritic cells, in-vivo",
author = "Forrester, {John Vincent} and Heping Xu and T. Lambe and Cornall, {R. J.}",
year = "2008",
month = "8",
doi = "10.1038/mi.2008.27",
language = "English",
volume = "1",
pages = "372--381",
journal = "Mucosal Immunology",
issn = "1933-0219",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Immune privilege or privileged immunity?

AU - Forrester, John Vincent

AU - Xu, Heping

AU - Lambe, T.

AU - Cornall, R. J.

PY - 2008/8

Y1 - 2008/8

N2 - Immune privilege is a concept that has come of age. Where previously it was considered to be a passive phenomenon restricted to certain specialized tissues, it is now viewed as comprising several mechanisms, both active and passive, shared in many aspects with emerging notions of the mechanisms of peripheral tolerance. The relative degrees of immune privilege vary from tissue to tissue depending on the number and strength of each of the mechanisms contained in that tissue. Immune privilege can be generated in non-privileged sites such as the skin and allografts, and is a property of the tissue itself. We therefore propose that, in addition to canonical central and peripheral tolerance mechanisms, there is a third route whereby the organism promotes self-antigen non-reactivity centered on the specific properties of each tissue and varying accordingly (relative degrees of immune privilege). This third mechanism of inducing immunological tolerance, as it is a local tissue phenomenon, might have particular therapeutic significance, for instance in devising strategies for induction of immunity to tumors by disrupting immune privilege or in preventing graft rejection by promoting immune privilege.

AB - Immune privilege is a concept that has come of age. Where previously it was considered to be a passive phenomenon restricted to certain specialized tissues, it is now viewed as comprising several mechanisms, both active and passive, shared in many aspects with emerging notions of the mechanisms of peripheral tolerance. The relative degrees of immune privilege vary from tissue to tissue depending on the number and strength of each of the mechanisms contained in that tissue. Immune privilege can be generated in non-privileged sites such as the skin and allografts, and is a property of the tissue itself. We therefore propose that, in addition to canonical central and peripheral tolerance mechanisms, there is a third route whereby the organism promotes self-antigen non-reactivity centered on the specific properties of each tissue and varying accordingly (relative degrees of immune privilege). This third mechanism of inducing immunological tolerance, as it is a local tissue phenomenon, might have particular therapeutic significance, for instance in devising strategies for induction of immunity to tumors by disrupting immune privilege or in preventing graft rejection by promoting immune privilege.

KW - regulatory T-cells

KW - blood-brain-barrier

KW - experimental autoimmune uveitis

KW - long-term acceptance

KW - draining lymph-node

KW - human hair follicle

KW - FAS ligand

KW - anterior-chamber

KW - dendritic cells

KW - in-vivo

U2 - 10.1038/mi.2008.27

DO - 10.1038/mi.2008.27

M3 - Article

VL - 1

SP - 372

EP - 381

JO - Mucosal Immunology

JF - Mucosal Immunology

SN - 1933-0219

IS - 5

ER -