Immunogenetic analysis of HLA-DR10 homozygous individuals

Neil Thomas Young, J Thompson, K Gibson, K Dewar, C Darke

Research output: Contribution to journalArticle

Abstract

Molecular, cellular and serological analysis of Major Histocompatibility Complex alleles was performed on three individuals who appeared to be HLA-DR10 homozygous by DNA restriction fragment analysis. Each donor was of different ethnic origin: Caucasoid, Asian Indian and African Negroid. The results of our studies show that the Caucasoid and Asian donors are indeed homozygous for the HLA-DR10 allele, while the African donor also possesses the DRB1*0103 allele. Homozygosity for the HLA-A1-B37-Cw6-DR10-DQ5 haplotype in the Caucasoid donor was confirmed by familial segregation analysis. The B-lymphoblastoid cell line produced from this donor should prove useful in studies of HLA immunogenetics.
Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalEuropean Journal of Immunogenetics
Volume22
Issue number2
DOIs
Publication statusPublished - 1 Apr 1995

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Keywords

  • African Continental Ancestry Group
  • Alleles
  • B-Lymphocytes
  • Cell Line, Transformed
  • European Continental Ancestry Group
  • Gene Frequency
  • Genes, MHC Class II
  • Great Britain
  • HLA Antigens
  • HLA-DR Antigens
  • Haplotypes
  • Homozygote
  • Humans
  • India
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Senegal

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