Immunogenetic analysis of HLA-DR10 homozygous individuals

Neil Thomas Young, J Thompson, K Gibson, K Dewar, C Darke

Research output: Contribution to journalArticle

Abstract

Molecular, cellular and serological analysis of Major Histocompatibility Complex alleles was performed on three individuals who appeared to be HLA-DR10 homozygous by DNA restriction fragment analysis. Each donor was of different ethnic origin: Caucasoid, Asian Indian and African Negroid. The results of our studies show that the Caucasoid and Asian donors are indeed homozygous for the HLA-DR10 allele, while the African donor also possesses the DRB1*0103 allele. Homozygosity for the HLA-A1-B37-Cw6-DR10-DQ5 haplotype in the Caucasoid donor was confirmed by familial segregation analysis. The B-lymphoblastoid cell line produced from this donor should prove useful in studies of HLA immunogenetics.
Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalEuropean Journal of Immunogenetics
Volume22
Issue number2
DOIs
Publication statusPublished - 1 Apr 1995

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Immunogenetics
Tissue Donors
Alleles
HLA-B37 Antigen
HLA-A1 Antigen
Major Histocompatibility Complex
Haplotypes
HLA-DR10 antigen
Cell Line
DNA

Keywords

  • African Continental Ancestry Group
  • Alleles
  • B-Lymphocytes
  • Cell Line, Transformed
  • European Continental Ancestry Group
  • Gene Frequency
  • Genes, MHC Class II
  • Great Britain
  • HLA Antigens
  • HLA-DR Antigens
  • Haplotypes
  • Homozygote
  • Humans
  • India
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Senegal

Cite this

Immunogenetic analysis of HLA-DR10 homozygous individuals. / Young, Neil Thomas; Thompson, J; Gibson, K; Dewar, K; Darke, C.

In: European Journal of Immunogenetics, Vol. 22, No. 2, 01.04.1995, p. 191-197.

Research output: Contribution to journalArticle

Young, NT, Thompson, J, Gibson, K, Dewar, K & Darke, C 1995, 'Immunogenetic analysis of HLA-DR10 homozygous individuals', European Journal of Immunogenetics, vol. 22, no. 2, pp. 191-197. https://doi.org/10.1111/j.1744-313X.1995.tb00230.x
Young, Neil Thomas ; Thompson, J ; Gibson, K ; Dewar, K ; Darke, C. / Immunogenetic analysis of HLA-DR10 homozygous individuals. In: European Journal of Immunogenetics. 1995 ; Vol. 22, No. 2. pp. 191-197.
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