Immunogenetic analysis of HLA-DR10 homozygous individuals

Neil Thomas Young; J Thompson; K Gibson; K Dewar; C Darke

doi:10.1111/j.1744-313X.1995.tb00230.x

Immunogenetic analysis of HLA-DR10 homozygous individuals

Neil Thomas Young, J Thompson, K Gibson, K Dewar, C Darke

Applied Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Molecular, cellular and serological analysis of Major Histocompatibility Complex alleles was performed on three individuals who appeared to be HLA-DR10 homozygous by DNA restriction fragment analysis. Each donor was of different ethnic origin: Caucasoid, Asian Indian and African Negroid. The results of our studies show that the Caucasoid and Asian donors are indeed homozygous for the HLA-DR10 allele, while the African donor also possesses the DRB1*0103 allele. Homozygosity for the HLA-A1-B37-Cw6-DR10-DQ5 haplotype in the Caucasoid donor was confirmed by familial segregation analysis. The B-lymphoblastoid cell line produced from this donor should prove useful in studies of HLA immunogenetics.

Original language	English
Pages (from-to)	191-197
Number of pages	7
Journal	European Journal of Immunogenetics
Volume	22
Issue number	2
DOIs	https://doi.org/10.1111/j.1744-313X.1995.tb00230.x
Publication status	Published - 1 Apr 1995

Keywords

African Continental Ancestry Group
Alleles
B-Lymphocytes
Cell Line, Transformed
European Continental Ancestry Group
Gene Frequency
Genes, MHC Class II
Great Britain
HLA Antigens
HLA-DR Antigens
Haplotypes
Homozygote
Humans
India
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Senegal

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10.1111/j.1744-313X.1995.tb00230.x

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title = "Immunogenetic analysis of HLA-DR10 homozygous individuals",

abstract = "Molecular, cellular and serological analysis of Major Histocompatibility Complex alleles was performed on three individuals who appeared to be HLA-DR10 homozygous by DNA restriction fragment analysis. Each donor was of different ethnic origin: Caucasoid, Asian Indian and African Negroid. The results of our studies show that the Caucasoid and Asian donors are indeed homozygous for the HLA-DR10 allele, while the African donor also possesses the DRB1*0103 allele. Homozygosity for the HLA-A1-B37-Cw6-DR10-DQ5 haplotype in the Caucasoid donor was confirmed by familial segregation analysis. The B-lymphoblastoid cell line produced from this donor should prove useful in studies of HLA immunogenetics.",

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author = "Young, {Neil Thomas} and J Thompson and K Gibson and K Dewar and C Darke",

year = "1995",

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doi = "10.1111/j.1744-313X.1995.tb00230.x",

language = "English",

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pages = "191--197",

journal = "European Journal of Immunogenetics",

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TY - JOUR

T1 - Immunogenetic analysis of HLA-DR10 homozygous individuals

AU - Young, Neil Thomas

AU - Thompson, J

AU - Gibson, K

AU - Dewar, K

AU - Darke, C

PY - 1995/4/1

Y1 - 1995/4/1

N2 - Molecular, cellular and serological analysis of Major Histocompatibility Complex alleles was performed on three individuals who appeared to be HLA-DR10 homozygous by DNA restriction fragment analysis. Each donor was of different ethnic origin: Caucasoid, Asian Indian and African Negroid. The results of our studies show that the Caucasoid and Asian donors are indeed homozygous for the HLA-DR10 allele, while the African donor also possesses the DRB1*0103 allele. Homozygosity for the HLA-A1-B37-Cw6-DR10-DQ5 haplotype in the Caucasoid donor was confirmed by familial segregation analysis. The B-lymphoblastoid cell line produced from this donor should prove useful in studies of HLA immunogenetics.

AB - Molecular, cellular and serological analysis of Major Histocompatibility Complex alleles was performed on three individuals who appeared to be HLA-DR10 homozygous by DNA restriction fragment analysis. Each donor was of different ethnic origin: Caucasoid, Asian Indian and African Negroid. The results of our studies show that the Caucasoid and Asian donors are indeed homozygous for the HLA-DR10 allele, while the African donor also possesses the DRB1*0103 allele. Homozygosity for the HLA-A1-B37-Cw6-DR10-DQ5 haplotype in the Caucasoid donor was confirmed by familial segregation analysis. The B-lymphoblastoid cell line produced from this donor should prove useful in studies of HLA immunogenetics.

KW - African Continental Ancestry Group

KW - Alleles

KW - B-Lymphocytes

KW - Cell Line, Transformed

KW - European Continental Ancestry Group

KW - Gene Frequency

KW - Genes, MHC Class II

KW - Great Britain

KW - HLA Antigens

KW - HLA-DR Antigens

KW - Haplotypes

KW - Homozygote

KW - Humans

KW - India

KW - Polymerase Chain Reaction

KW - Polymorphism, Restriction Fragment Length

KW - Senegal

U2 - 10.1111/j.1744-313X.1995.tb00230.x

DO - 10.1111/j.1744-313X.1995.tb00230.x

M3 - Article

C2 - 7605777

VL - 22

SP - 191

EP - 197

JO - European Journal of Immunogenetics

JF - European Journal of Immunogenetics

SN - 0960-7420

IS - 2

ER -

Immunogenetic analysis of HLA-DR10 homozygous individuals

Abstract

Keywords

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