Immunoglobulin allotype frequencies in responders and nonresponders to the Rh(D) antigen

Neil Thomas Young, J Street, C Darke

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Immunoglobulin allotype frequencies were determined in well characterised groups of responders (n = 160) and non-responders (n = 32) to Rh(D) antigen immunisation. Allotype frequencies in these groups were compared with frequencies in a normal control population (n = 500). No significant differences in allotype frequencies were observed between the responder and non-responder groups, or when these two groups where compared with a normal control population. These results suggest that the immunoglobulin heavy-chain genes do not influence the anti-Rh(D) immune response.
Original languageEnglish
Pages (from-to)88-91
Number of pages4
JournalExperimental and Clinical Immunogenetics
Volume12
Issue number2
Publication statusPublished - 1 Jan 1995

Keywords

  • Female
  • Haplotypes
  • Humans
  • Immunoglobulin Allotypes
  • Immunoglobulin G
  • Immunoglobulin Gm Allotypes
  • Isoantibodies
  • Male
  • Rh-Hr Blood-Group System

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