Immunology of fungal disease

Ivy M. Dambuza, Jeanette Wagener, Gordon Douglas Brown, Neil A. R. Gow

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Advances in modern medicine, such as organ transplantations and the appearance of HIV (human immunodeficiency virus), have significantly increased the patient cohort at risk of developing chronic superficial and life-threatening invasive fungal infections. To tackle this major healthcare problem, there is an urgent need to understand immunity against fungal infections for the purposes of vaccine design or immune-mediated interventions. In this chapter, we give an overview of the components of the innate and adaptive immune system and how they contribute to host defence against fungi. The various cell types contributing to fungal recognition and the subsequent stimulation of phagocytosis, the activation of inflammatory and B- and T-cell responses, and fungal clearance are discussed using the major fungal pathogens as model systems.
Original languageEnglish
Title of host publicationOxford Textbook of Medical Mycology
EditorsChristopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, Rohini J. Manuel
PublisherOxford University Press
ISBN (Print)9780198755388
DOIs
Publication statusPublished - Jan 2018

Publication series

NameOxford Textbooks in Infectious Disease and Microbiology
PublisherOxford University Press

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  • Cite this

    Dambuza, I. M., Wagener, J., Brown, G. D., & Gow, N. A. R. (2018). Immunology of fungal disease. In C. C. Kibbler, R. Barton, N. A. R. Gow, S. Howell, D. M. MacCallum, & R. J. Manuel (Eds.), Oxford Textbook of Medical Mycology [9] (Oxford Textbooks in Infectious Disease and Microbiology). Oxford University Press. https://doi.org/10.1093/med/9780198755388.003.0009