Immunology of fungal disease

Ivy M. Dambuza; Jeanette Wagener; Gordon Douglas Brown; Neil A. R. Gow

doi:10.1093/med/9780198755388.003.0009

Immunology of fungal disease

Ivy M. Dambuza, Jeanette Wagener, Gordon Douglas Brown, Neil A. R. Gow

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Advances in modern medicine, such as organ transplantations and the appearance of HIV (human immunodeficiency virus), have significantly increased the patient cohort at risk of developing chronic superficial and life-threatening invasive fungal infections. To tackle this major healthcare problem, there is an urgent need to understand immunity against fungal infections for the purposes of vaccine design or immune-mediated interventions. In this chapter, we give an overview of the components of the innate and adaptive immune system and how they contribute to host defence against fungi. The various cell types contributing to fungal recognition and the subsequent stimulation of phagocytosis, the activation of inflammatory and B- and T-cell responses, and fungal clearance are discussed using the major fungal pathogens as model systems.

Original language	English
Title of host publication	Oxford Textbook of Medical Mycology
Editors	Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, Rohini J. Manuel
Publisher	Oxford University Press
ISBN (Print)	9780198755388
DOIs	https://doi.org/10.1093/med/9780198755388.003.0009
Publication status	Published - Jan 2018

Publication series

Name	Oxford Textbooks in Infectious Disease and Microbiology
Publisher	Oxford University Press

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Immunology of fungal disease. / Dambuza, Ivy M.; Wagener, Jeanette; Brown, Gordon Douglas et al.

Oxford Textbook of Medical Mycology. ed. / Christopher C. Kibbler; Richard Barton; Neil A. R. Gow; Susan Howell; Donna M. MacCallum; Rohini J. Manuel. Oxford University Press, 2018. 9 (Oxford Textbooks in Infectious Disease and Microbiology).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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AB - Advances in modern medicine, such as organ transplantations and the appearance of HIV (human immunodeficiency virus), have significantly increased the patient cohort at risk of developing chronic superficial and life-threatening invasive fungal infections. To tackle this major healthcare problem, there is an urgent need to understand immunity against fungal infections for the purposes of vaccine design or immune-mediated interventions. In this chapter, we give an overview of the components of the innate and adaptive immune system and how they contribute to host defence against fungi. The various cell types contributing to fungal recognition and the subsequent stimulation of phagocytosis, the activation of inflammatory and B- and T-cell responses, and fungal clearance are discussed using the major fungal pathogens as model systems.

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Immunology of fungal disease

Abstract

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