Immunomodulation in the critically ill

N. R. Webster, H. F. Galley (Corresponding Author)

Research output: Contribution to journalReview article

50 Citations (Scopus)

Abstract

Immunotherapy in the critically ill is an appealing notion because of the apparent abnormal immune and inflammatory responses seen in so many patients. The administration of a medication that could alter immune responses and decrease mortality in patients with sepsis could represent a 'magic bullet'. Various approaches have been tried over the last 20 yr: steroids; anti-endotoxin or anti-cytokine antibodies; cytokine receptor antagonists; and other agents with immune-modulating side-effects. However, in some respects, research along these lines has been unsuccessful or disappointing at best. The current state of knowledge is summarized with particular reference to sepsis and the acute respiratory distress syndrome.

Original languageEnglish
Pages (from-to)70-81
Number of pages12
JournalBritish Journal of Anaesthesia
Volume103
Issue number1
DOIs
Publication statusPublished - 1 Jul 2009

Fingerprint

Immunomodulation
Critical Illness
Sepsis
Magic
Cytokine Receptors
Adult Respiratory Distress Syndrome
Endotoxins
Immunotherapy
Anti-Idiotypic Antibodies
Steroids
Cytokines
Mortality
Research

Keywords

  • Cytokines
  • Immune system
  • Intensive care
  • Respiratory distress system, adult
  • Systemic inflammatory response system

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Immunomodulation in the critically ill. / Webster, N. R.; Galley, H. F. (Corresponding Author).

In: British Journal of Anaesthesia, Vol. 103, No. 1, 01.07.2009, p. 70-81.

Research output: Contribution to journalReview article

Webster, N. R. ; Galley, H. F. / Immunomodulation in the critically ill. In: British Journal of Anaesthesia. 2009 ; Vol. 103, No. 1. pp. 70-81.
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