Abstract
Multipotent mesenchymal stromal cells isolated from bone marrow and other sites are currently being studied to determine their potential role in the pathogenesis and/or management of autoimmune diseases. In vitro studies have shown that they exhibit a dose-dependent antiproliferative effect on T and B lymphocytes, dendritic cells, natural killer cells and various B cell tumour lines--an effect that is both cell contact and soluble factor dependent. Animal models of autoimmune disease treated with multipotent mesenchymal stromal cells have mostly exhibited a positive clinical response, as have a limited number of patients suffering from acute graft versus host disease. This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts.
Original language | English |
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Pages (from-to) | 301 |
Journal | Arthritis Research & Therapy |
Volume | 9 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 2007 |
Keywords
- Animals
- Arthritis, Rheumatoid
- Congresses as Topic
- Humans
- Immunologic Factors
- London
- Mesenchymal Stem Cell Transplantation
- Mesenchymal Stem Cells
- Rheumatology