Immunomodulatory properties of mesenchymal stem cells:  a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005

Alan Tyndall; Ulrich A.  Walker; Andrew Cope; Francesco Dazzi; Cosimo De Bari; Willem Fibbe; Serena Guiducci; Simon Jones; Christian Jorgensen; Katarina Le Blanc; Frank Luyten; Dennis McGonagle; Ivan Martin; Chiara Bocelli-Tyndall; Giuseppina Pennesi; Vito Pistoia; Constantino Pitzalis; Antonio Uccelli; Nico Wulffraat; Marc Feldmann

doi:10.1186/ar2103

Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005

Alan Tyndall, Ulrich A. Walker, Andrew Cope, Francesco Dazzi, Cosimo De Bari, Willem Fibbe, Serena Guiducci, Simon Jones, Christian Jorgensen, Katarina Le Blanc, Frank Luyten, Dennis McGonagle, Ivan Martin, Chiara Bocelli-Tyndall, Giuseppina Pennesi, Vito Pistoia, Constantino Pitzalis, Antonio Uccelli, Nico Wulffraat, Marc Feldmann

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Abstract

Multipotent mesenchymal stromal cells isolated from bone marrow and other sites are currently being studied to determine their potential role in the pathogenesis and/or management of autoimmune diseases. In vitro studies have shown that they exhibit a dose-dependent antiproliferative effect on T and B lymphocytes, dendritic cells, natural killer cells and various B cell tumour lines--an effect that is both cell contact and soluble factor dependent. Animal models of autoimmune disease treated with multipotent mesenchymal stromal cells have mostly exhibited a positive clinical response, as have a limited number of patients suffering from acute graft versus host disease. This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts.

Original language	English
Pages (from-to)	301
Journal	Arthritis Research & Therapy
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/ar2103
Publication status	Published - 1 Jan 2007

Keywords

Animals
Arthritis, Rheumatoid
Congresses as Topic
Humans
Immunologic Factors
London
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
Rheumatology

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Tyndall ART07 Immunomodulatory properties of MSCsFinal published version, 122 KB

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Tyndall, A., Walker, U. A., Cope, A., Dazzi, F., De Bari, C., Fibbe, W., Guiducci, S., Jones, S., Jorgensen, C., Le Blanc, K., Luyten, F., McGonagle, D., Martin, I., Bocelli-Tyndall, C., Pennesi, G., Pistoia, V., Pitzalis, C., Uccelli, A., Wulffraat, N., & Feldmann, M. (2007). Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005. Arthritis Research & Therapy, 9(1), 301. https://doi.org/10.1186/ar2103

Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005. / Tyndall, Alan; Walker, Ulrich A. ; Cope, Andrew et al.
In: Arthritis Research & Therapy, Vol. 9, No. 1, 01.01.2007, p. 301.

Research output: Contribution to journal › Article › peer-review

Tyndall, A, Walker, UA, Cope, A, Dazzi, F, De Bari, C, Fibbe, W, Guiducci, S, Jones, S, Jorgensen, C, Le Blanc, K, Luyten, F, McGonagle, D, Martin, I, Bocelli-Tyndall, C, Pennesi, G, Pistoia, V, Pitzalis, C, Uccelli, A, Wulffraat, N & Feldmann, M 2007, 'Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005', Arthritis Research & Therapy, vol. 9, no. 1, pp. 301. https://doi.org/10.1186/ar2103

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Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005

Abstract

Keywords

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