TY - JOUR
T1 - Impact of age on the prognostic value of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention
T2 - Insights from the British cardiovascular intervention society
AU - Kwok, Chun Shing
AU - Anderson, Simon G
AU - McAllister, Katherine S L
AU - Sperrin, Matthew
AU - O'Kane, Peter D
AU - Keavney, Bernard
AU - Nolan, James
AU - Myint, Phyo Kyaw
AU - Zaman, Azfar
AU - Buchan, Iain
AU - Ludman, Peter F
AU - de Belder, Mark A
AU - Mamas, Mamas A
AU - on behalf of the British Cardiovascular Intervention Society and the National Institute for Cardiovascular Outcomes Research
N1 - Copyright © 2014 Wiley Periodicals, Inc.
PY - 2015/5
Y1 - 2015/5
N2 - BACKGROUND: Around one third of patients undergoing percutaneous coronary intervention (PCI) have left ventricular (LV) dysfunction. Whilst the prevalence of LV dysfunction is known to increase with age, the prevalence of LV dysfunction in different age groups in the PCI setting is not known and the effect of age on the prognostic value of LV function in the PCI setting has not been examined.METHODS: The relationship between LV function and 30-day mortality in patients undergoing PCI in different age groups (<60 years, 60 to <70 years, 70 to <80 years and ≥80 years) was studied in 246,840 patients in the UK between 2006 and 2011.RESULTS: Prevalent LV dysfunction in patients undergoing PCI increased with age; 25,106/83,161 (30.2%: <60 years), 24,114/76,895 (31.4%: 60 to <70 years), 23,580/64,711 36.4% (70 to <80 years) and 9,851/22,073 (44.6%) in patients aged 80 or over (P < 0.0001). Poor LV function was independently associated with increased risk of 30-day mortality outcomes in all age groups (OR 5.65:95% CI 4.21-7.58, age <60 years; OR 5.07: 95% CI 3.91-6.57, age 60 to <70 years; OR 4.50: 95% CI 3.64-5.57, 70 to <80 years and OR 4.83:95% CI 3.79-6.15, age ≥80 years).CONCLUSIONS: Our analysis suggests that worsening LV function is an important independent predictor of worse 30-day mortality outcomes across all age groups and underscores the need for a measure of LV function in all patients for accurate risk stratification prior to PCI. © 2014 Wiley Periodicals, Inc.
AB - BACKGROUND: Around one third of patients undergoing percutaneous coronary intervention (PCI) have left ventricular (LV) dysfunction. Whilst the prevalence of LV dysfunction is known to increase with age, the prevalence of LV dysfunction in different age groups in the PCI setting is not known and the effect of age on the prognostic value of LV function in the PCI setting has not been examined.METHODS: The relationship between LV function and 30-day mortality in patients undergoing PCI in different age groups (<60 years, 60 to <70 years, 70 to <80 years and ≥80 years) was studied in 246,840 patients in the UK between 2006 and 2011.RESULTS: Prevalent LV dysfunction in patients undergoing PCI increased with age; 25,106/83,161 (30.2%: <60 years), 24,114/76,895 (31.4%: 60 to <70 years), 23,580/64,711 36.4% (70 to <80 years) and 9,851/22,073 (44.6%) in patients aged 80 or over (P < 0.0001). Poor LV function was independently associated with increased risk of 30-day mortality outcomes in all age groups (OR 5.65:95% CI 4.21-7.58, age <60 years; OR 5.07: 95% CI 3.91-6.57, age 60 to <70 years; OR 4.50: 95% CI 3.64-5.57, 70 to <80 years and OR 4.83:95% CI 3.79-6.15, age ≥80 years).CONCLUSIONS: Our analysis suggests that worsening LV function is an important independent predictor of worse 30-day mortality outcomes across all age groups and underscores the need for a measure of LV function in all patients for accurate risk stratification prior to PCI. © 2014 Wiley Periodicals, Inc.
KW - age
KW - left ventricular function
KW - PCI
U2 - 10.1002/ccd.25732
DO - 10.1002/ccd.25732
M3 - Article
C2 - 25408308
SN - 1522-726X
VL - 85
SP - 944
EP - 951
JO - Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
JF - Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
IS - 6
ER -