Impact of age on the prognostic value of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: Insights from the British cardiovascular intervention society

Chun Shing Kwok, Simon G Anderson, Katherine S L McAllister, Matthew Sperrin, Peter D O'Kane, Bernard Keavney, James Nolan, Phyo Kyaw Myint, Azfar Zaman, Iain Buchan, Peter F Ludman, Mark A de Belder, Mamas A Mamas, on behalf of the British Cardiovascular Intervention Society and the National Institute for Cardiovascular Outcomes Research

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Abstract

BACKGROUND: Around one third of patients undergoing percutaneous coronary intervention (PCI) have left ventricular (LV) dysfunction. Whilst the prevalence of LV dysfunction is known to increase with age, the prevalence of LV dysfunction in different age groups in the PCI setting is not known and the effect of age on the prognostic value of LV function in the PCI setting has not been examined.

METHODS: The relationship between LV function and 30-day mortality in patients undergoing PCI in different age groups (<60 years, 60 to <70 years, 70 to <80 years and ≥80 years) was studied in 246,840 patients in the UK between 2006 and 2011.

RESULTS: Prevalent LV dysfunction in patients undergoing PCI increased with age; 25,106/83,161 (30.2%: <60 years), 24,114/76,895 (31.4%: 60 to <70 years), 23,580/64,711 36.4% (70 to <80 years) and 9,851/22,073 (44.6%) in patients aged 80 or over (P < 0.0001). Poor LV function was independently associated with increased risk of 30-day mortality outcomes in all age groups (OR 5.65:95% CI 4.21-7.58, age <60 years; OR 5.07: 95% CI 3.91-6.57, age 60 to <70 years; OR 4.50: 95% CI 3.64-5.57, 70 to <80 years and OR 4.83:95% CI 3.79-6.15, age ≥80 years).

CONCLUSIONS: Our analysis suggests that worsening LV function is an important independent predictor of worse 30-day mortality outcomes across all age groups and underscores the need for a measure of LV function in all patients for accurate risk stratification prior to PCI. © 2014 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)944-951
Number of pages8
JournalCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Volume85
Issue number6
Early online date27 Nov 2014
DOIs
Publication statusPublished - May 2015

Keywords

  • age
  • left ventricular function
  • PCI

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    Kwok, C. S., Anderson, S. G., McAllister, K. S. L., Sperrin, M., O'Kane, P. D., Keavney, B., Nolan, J., Myint, P. K., Zaman, A., Buchan, I., Ludman, P. F., de Belder, M. A., Mamas, M. A., & on behalf of the British Cardiovascular Intervention Society and the National Institute for Cardiovascular Outcomes Research (2015). Impact of age on the prognostic value of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: Insights from the British cardiovascular intervention society. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 85(6), 944-951. https://doi.org/10.1002/ccd.25732