Impact of early consumption of high-fat diet on the mesolimbic dopaminergic system

F. Naneix, F. Tantot, C. Glangetas, J. Kaufling, Y. Janthakhin, C. Boitard, V. De Smedt-Peyrusse, J. R. Pape, S. Vancassel, P. Trifilieff, F. Georges, E. Coutureau, Guillaume Ferreira*

*Corresponding author for this work

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Increasing evidence suggest that consumption of high-fat diet (HFD) can impact the maturation of brain circuits, such as during adolescence, which could account for behavioral alterations associated with obesity. In the present study, we used behavioral sensitization to amphetamine to investigate the effect of periadolescent HFD exposure (pHFD) in rats on the functionality of the dopamine (DA) system, a central actor in food reward processing. pHFD does not affect responding to an acute injection, however, a single exposure to amphetamine is sufficient to induce locomotor sensitization in pHFD rats. This is paralleled by rapid neurobiological adaptations within the DA system. In pHFD- exposed animals, a single amphetamine exposure induces an increase in bursting activity of DA cells in the ventral tegmental area (VTA) as well as higher DA release and greater expression of (tyrosine hydroxylase, TH) in the nucleus accumbens (NAc). Post-synaptically, pHFD animals display an increase in NAc D2 receptors and c-Fos expression after amphetamine injection. These findings highlight the vulnerability of DA system to the consumption of HFD during adolescence that may support deficits in reward-related processes observed in obesity.

Original languageEnglish
Article numbere0120-17.2017
Number of pages12
JournaleNeuro
Volume4
Issue number3
Early online date29 May 2017
DOIs
Publication statusPublished - 2017

Keywords

  • Adolescence
  • Amphetamine
  • Dopamine
  • High-fat diet
  • Nucleus accumbens
  • Sensitization

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  • Activities

    • 1 Conference presentation
    • 1 Oral presentation

    Feed your teenage brain: impact of food diets during adolescence on dopamine circuits and functions

    Fabien Naneix (Speaker)

    23 Sep 2019

    Activity: Talk, presentation, public lecture, public engagement, outreach and knowledge exchangeConference presentation

    Feed your teenage brain: how food diet during adolescence can affect cognitive and brain development

    Fabien Naneix (Speaker)

    2017

    Activity: Talk, presentation, public lecture, public engagement, outreach and knowledge exchangeOral presentation

    Cite this

    Naneix, F., Tantot, F., Glangetas, C., Kaufling, J., Janthakhin, Y., Boitard, C., De Smedt-Peyrusse, V., Pape, J. R., Vancassel, S., Trifilieff, P., Georges, F., Coutureau, E., & Ferreira, G. (2017). Impact of early consumption of high-fat diet on the mesolimbic dopaminergic system. eNeuro, 4(3), [e0120-17.2017]. https://doi.org/10.1523/ENEURO.0120-17.2017