TY - JOUR
T1 - Impact of exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis
T2 - A systematic review of randomised controlled trials
AU - Bricca, Alessio
AU - Juhl, Carsten B.
AU - Steultjens, Martijn
AU - Wirth, Wolfgang
AU - Roos, Ewa M.
N1 - This project is supported by a European Union Seventh Framework Programme (FP7-PEOPLE-2013-ITN; KNEEMO) under grant agreement number 607510.
PY - 2019/7/17
Y1 - 2019/7/17
N2 - Objective: To investigate the impact of knee joint loading exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis (OA) by conducting a systematic review of randomised controlled trials (RCTs). Design: We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Data sources: We performed a literature search with no restriction on publication year or language in MEDLINE, EMBASE, CINAHL, the Cochrane Central Register of Controlled Trials and Web of Science up to September 2017. Eligibility criteria: RCTs investigating the impact of exercise on MRI-assessed articular cartilage in people over 18 years of age. Results: We included nine trials, including a total of 14 comparisons of cartilage morphometry, morphology and composition outcomes, of which two included participants at increased risk of knee OA and 12 included participants with knee OA. In participants at increased risk, one study comparison reported no effect on cartilage defects and one had positive effects on glycosaminoglycans (GAG). In participants with OA, six study comparisons reported no effect on cartilage thickness, volume or defects; one reported a negative effect and one no effect on GAG; two reported a positive effect and two no effect on collagen. Conclusions: Knee joint loading exercise seems to not be harmful for articular cartilage in people at increased risk of, or with, knee OA. However, the quality of evidence was low, including some interventions studying activities considered outside the therapeutic loading spectrum to promote cartilage health.
AB - Objective: To investigate the impact of knee joint loading exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis (OA) by conducting a systematic review of randomised controlled trials (RCTs). Design: We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Data sources: We performed a literature search with no restriction on publication year or language in MEDLINE, EMBASE, CINAHL, the Cochrane Central Register of Controlled Trials and Web of Science up to September 2017. Eligibility criteria: RCTs investigating the impact of exercise on MRI-assessed articular cartilage in people over 18 years of age. Results: We included nine trials, including a total of 14 comparisons of cartilage morphometry, morphology and composition outcomes, of which two included participants at increased risk of knee OA and 12 included participants with knee OA. In participants at increased risk, one study comparison reported no effect on cartilage defects and one had positive effects on glycosaminoglycans (GAG). In participants with OA, six study comparisons reported no effect on cartilage thickness, volume or defects; one reported a negative effect and one no effect on GAG; two reported a positive effect and two no effect on collagen. Conclusions: Knee joint loading exercise seems to not be harmful for articular cartilage in people at increased risk of, or with, knee OA. However, the quality of evidence was low, including some interventions studying activities considered outside the therapeutic loading spectrum to promote cartilage health.
KW - cartilage
KW - collagen
KW - evidence based review
KW - exercise
KW - load
UR - http://www.scopus.com/inward/record.url?scp=85049122091&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/impact-exercise-articular-cartilage-people-risk-established-knee-osteoarthritis-systematic-review-ra
UR - https://abdn.pure.elsevier.com/en/en/researchoutput/impact-of-exercise-on-articular-cartilage-in-people-at-risk-of-or-with-established-knee-osteoarthritis(837ddb3e-fba9-4ac8-8fe6-97e3eab76e6e).html
U2 - 10.1136/bjsports-2017-098661
DO - 10.1136/bjsports-2017-098661
M3 - Article
SN - 0306-3674
VL - 53
SP - 940
EP - 947
JO - British Journal of Sports Medicine
JF - British Journal of Sports Medicine
IS - 15
ER -