Impact of Exercise Therapy on Molecular Biomarkers Related to Cartilage and Inflammation in Individuals at Risk of, or With Established, Knee Osteoarthritis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Alessio Bricca* (Corresponding Author), André Struglics, Staffan Larsson, Martijn Steultjens, Carsten B. Juhl, Ewa M. Roos

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective. To investigate the impact of exercise therapy on molecular biomarkers related to cartilage and inflammation in people at risk of, or with established, knee osteoarthritis by conducting a systematic review of randomized controlled trials (RCTs).

Methods. Literature search up to September 2017 in five major databases with no restriction on publication year or language. Data were extracted from the first available follow-up time point and we performed a narrative synthesis for the effect of exercise therapy on molecular biomarkers related to cartilage and inflammation. A subset of studies reporting sufficient data was combined in a meta-analysis, using an adjusted random effects model.

Results. Twelve RCTs, involving 57 study comparisons at 4 to 24 weeks following an exercise therapy intervention were included. Exercise therapy decreased molecular biomarkers in 17 (30%) study comparisons, had no effect in 36 (63%), and increased molecular biomarkers in four (7%) study comparisons. Meta-analyses of nine biomarkers showed that exercise therapy was associated with non-significant reductions of C-reactive protein, C-terminal crosslinking telopeptide of type II collagen, tumor necrosis factor alpha (TNF-α), soluble TNF-α receptor-1 and -2, C2C neoepitope of type II collagen and cartilage oligomeric matrix protein compared to non-exercising control groups and had no effect on interleukin-6 and soluble interleukin 6 receptor.

Conclusions. Exercise therapy is not harmful, as it does not increase the concentration of molecular biomarkers related to cartilage turnover and inflammation, implicated in osteoarthritis progression. The overall quality of evidence was downgraded to low because of the limited number of RCTs available.
Original languageEnglish
Pages (from-to)1504-1515
Number of pages12
JournalArthritis Care & Research
Volume71
Issue number11
Early online date29 Oct 2019
DOIs
Publication statusPublished - Nov 2019

Keywords

  • exercise
  • cartilage
  • humans
  • knee
  • molecular biomarkers
  • C-REACTIVE PROTEIN
  • SYNOVIAL-FLUID
  • SEARCH FILTER
  • WEIGHT-LOSS
  • SERUM
  • OLIGOMERIC MATRIX PROTEIN
  • INTENSIVE DIET
  • PAIN
  • OBESE ADULTS
  • PHYSICAL-ACTIVITY

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