Impact of manipulations of myogenesis in utero on the performance of adult skeletal muscle

Charlotte Maltin, Margaret Inkster Delday, K D Sinclair, John Steven, Alan Arthur Sneddon

Research output: Contribution to journalLiterature review

65 Citations (Scopus)

Abstract

The possibility that early fetal programming affects health or disease status in adult life has been considered in relation to tissues such as the cardiovascular system but not with respect to skeletal muscle. Since muscle mass and function are important for life, it is pertinent to ask whether events during the development of muscle in utero can affect the performance of the tissue in later life. This review discusses the factors that influence muscle performance, outlines the current understanding of myogenesis and examines how manipulations alter myogenic outcome after birth. The performance of muscle is determined by the number, type and size of the muscle fibres, these in turn being affected by a number of factors, and the evidence indicates that the proportions of types of muscle fibre have a heritable component. The formation of muscle occurs early in embryogenesis and it appears that the major impacts on myogenesis are associated with extremes of treatment or embryo manipulations. The impact of extremes of treatment or embryo manipulations on myogenesis is seen in the secondary fibres whereas primary fibres appear to be insensitive or protected. Overall, the opportunities for manipulation of myogenesis in utero to improve adult performance are limited.

Original languageEnglish
Pages (from-to)359-374
Number of pages16
JournalReproduction
Volume122
Issue number3
DOIs
Publication statusPublished - Sep 2001

Keywords

  • LOW-BACK-PAIN
  • FIBER-TYPE CHARACTERISTICS
  • MYOSIN HEAVY-CHAIN
  • DORSAL NEURAL-TUBE
  • SOMITE FORMATION
  • PRECURSOR CELLS
  • EATING QUALITY
  • RETINOIC ACID
  • IN-VITRO
  • PRENATAL UNDERNUTRITION

Cite this