Impact of parental smoking on adipokine profiles and cardiometabolic risk factors in Chinese children

Yu Li, Dongmei Wang, Yuhan Wang, Yanglu Zhao, Lanwen Han, Ling Zhong, Qian Zhang, John R Speakman, Ming Li* (Corresponding Author), Shan Gao* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Citation (Scopus)
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Abstract

BACKGROUND AND AIMS: The mechanisms by which passive smoking leads to cardiometabolic risks, and the tissues involved still require elucidation. We aimed to evaluate the association of parental smoking exposure (PSE) with the secretion of adipocyte-derived hormones and cardiometabolic risk factors in Chinese children.

METHODS: We included 3150 school children aged 6-18 years from the Beijing Child and Adolescent Metabolic Syndrome (BCAMS) study. Data on PSE and potential confounders were collected. Six adipokines related to insulin resistance and metabolic syndrome (MetS) were measured.

RESULTS: PSE was reported in nearly two-thirds of the children. After adjusting for covariates, including age, sex, pubertal stages, lifestyle factors, and family history, PSE was independently associated with increases of 39.2% in leptin and 3.9% in retinol binding protein-4 and decreases of 11.4% in fibroblast growth factor 21 and 4.6% in adiponectin levels (p < 0.05 for all), plus risks for central obesity (OR 1.59, 95% CI 1.33-1.90), elevated blood pressure (1.22, 1.02-1.46) and MetS (1.43, 1.11-1.85). However, the associations of PSE with hypertension and MetS were abolished when adjusted for adiposity parameters or the above-mentioned adipokine profiles.

CONCLUSIONS: PSE was associated with dysregulation of adipokine levels, which might mediate the development of MetS in early life.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalAtherosclerosis
Volume301
Early online date5 Apr 2020
DOIs
Publication statusPublished - May 2020

Keywords

  • Parental smoking
  • Cardiometabolic factors
  • Adiposity
  • Adipokines
  • Children

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