Impact of postoperative non-steroidal anti-inflammatory drugs on adverse events after gastrointestinal surgery

S. J. Chapman, STARSurg Collaborative, J. Glasbey, M. Kelly, C. Khatri, D. Nepogodiev, J. E. F. Fitzgerald, A. Bhangu*, E. M. Harrison, R. Adams, K. Patel, C. Khatri, A. R. Retchless, M. Elsaddig, A. E. Curtis, D. Nepogodiev, J. Glasbey, R. McMahon, D. Mittapalli, L. A. Ferguson & 458 others S. V. Gentry, C. Y. N. Kong, Z. Naqvi, H. Amin, S. J. Chapman, M. Kelly, B. Chaudhry, J. Burke, I. Henderson, S. Trecarten, J. M. Clements, T. M. Drake, J. R. L. Wild, H. Venkatesh, N. Butters, Hassen Ahmeidat, N. Goergen, Rachel Adams, Douglas Black, Kim Robertson, G. M. Jama, S. A. McGuire, R. Ahl, T. S. Suri, R. Kuo, M. Fadhlillah, H. Mills, R. Mitchell, J. Goodship, M. Tan, T. Barker, T. Wright, W. Mohamad, N. Hanna, G. Laing, M. W. C. Warnock, P. R. Baird-Fraser, T. Logan, F. M. Young, A. C. Fane De Salis, R. McHugh, T. M. Drake, C. Hickson, J. Paszkiewicz, L. B. Anderson, D. Neeson, M. Mohan, Y. Narang, T. Brophy, R. Punj, S. Majumdar, S. Kauser, G. Jong, E. Palkhi, D. Finch, A. E. Curtis, H. Mitchell, N. Carter, T. Viyasar, T. Sammut, N. Cook, M. M. Powell, S. Horne, J. L. Y. Allen, D. Marshall, C. McIntyre, D. T. S. Koh, J. Shi, T. Reid, N. P. Armugam, J. Luck, T. Fozard, J. O'Callaghan, P. C. Copley, V. Tilliriou, R. Aiyer, A. Yazdi, A. Wiltshire, E. Blower, C. Jewitt, L. K. Cheung, S. Fourali, Y. Rahimi, R. Velho, C. Taylor, L. Satterthwaite, N. V. Eze, J. P. M. Johnston, R. S. McCain, E. C. F. Hess, R. P. Thumbadoo, E. J. H. Turner, R. Wookey, R. Morris, K. Gasteratos, E. Heywood, S. J. Simpson, Z. Rai, D. Kazzazi, J. Ducey, M. J. Livesey, C. Finan, E. Staunton, S. D. Haddad, R. Karanjia, I. Bokobza, M. Ahmed, J. Howell, R. Adams, C. Grainger, A. Woo, M. McDowall, F. Bulley, R. Keating, B. Tan, S. Sng, C. Brown, G. Aidoo-Micah, A. Champsi, R. Ellis, S. Darwazeh, R. Polson, J. Z. Chan, B. F. H. K. Chong, J. H. Park, C. Y. Kong, Y. P. Mogan, S. Stevens, H. K. Sekhon, R. McIntosh, D. W. Ochiltree, P. D. Jamieson, D. N. Naumann, D. M. Bowley, G. Howell, T. Clark, K. Dear, L. James, E. Upchurch, H. Wilson, M. Hughes, A. R. Retchless, S. M. Modayur, D. N. Naumann, D. M. Bowley, U. Datta, J. H. C. Chen, L. J. L. Williams, J. Selby, A. Prabhudesai, K. Mahomed, H. A. Shah, K. Kong, S. Chandramoorthy, L. Marshall, C. De Kauwe, R. Rana, J. Patel, T. Pezas, J. Ma, V. Stohlner, M. S. Kinsella, S. N. Gardiner, R. A. Smith, M. Glover, M. Akinfala, J. Z. C. Lee, V. Aggarwal, S. Waters, M. Atif, M. Hill, A. Ramasubramoni, Z. Jaffry, H. Sagoo, J. Jeyakumar, S. Kosasih, J. Davis, G. H. M. Stanley, J. Nijran, I. Tang, K. Mehta, A. Fillery, N. F. Watson, D. Shah, S. Naidu, T. K. Grewal, P. Singh, D. Reissis, C. Marusza, J. Luck, W. Pettit, S. Timbrell, R. Woods, J. Phillips, R. Vaughan, S. Dean, R. Gibby, T. F. Jones, R. Rao, H. D. T. Torrance, V. Thirumal, R. K. McMahon, D. Yap, D. Mittapalli, A. Shaw, H. A. Claireaux, Y. L. Pang, R. Narramore, C. Holmes, A. Caldwell, A. Daoub, L. Bibby, A. G. Hague, M. C. Sykes, K. Patel, P. Morar, G. Downes, S. Shah, S. Walimohamed, A. Alsulaimi, V. Biswas, B. Gnaneswaran, N. Davies, V. Narwani, D. Nepogodiev, J. Hernon, A. Jumbu, M. Ilyas, G. Johal, F. Atia, A. Williams, C. Chan, S. McAnelly, A. Evans, K. Y. Chan, K. Flegg, S. Carter, J. Coley, R. Khaw, N. Jayakody, B. Jones, N. Fawcett, C. Ghali, K. Jalundhwala, P. Ariyaratnam, H. Colville, M. Walls, J. Lindsay, M. Keane, S. Ban, C. Kambasha, S. Sait, M. Tahir, S. Trecarten, I. Henderson, R. Tharakan, J. Voll, H. Shiwani, Y. Al-Omran, A. Hawash, V. McCaughan, V. Shatkar, K. Gohil, A. Greenhalgh, E. Higgins, T. Moody, M. B. Booth, W. H. Chan, S. Shanthakumaran, N. Maple, D. McNish, B. Shahin, J. Nicholas, R. McDermid, P. Narayan, C. Brodie, S. Hurrey, V. Gentry, V. Panayi, B. Turner, K. Kopala, S. Clayton, A. Winfield, A. Mohamud, A. Venkatesh, S. Hosein, C. Olimpio, V. Gkiousias, J. M. Kilgour, E. Cogbill, M. Ramcharn, G. Carr, A. Bannerman, L. Grundy, S. White, A. Beamish, L. A. Ferguson, Y. N. Neo, A. R. Cragg, E. M. Harrison, A. Perkins, A. Wynn-Hebden, T. Khan, M. Ali, C. L. F. Battersby, R. S. Pinto, S. S. Poon, M. Patel, P. Patel, A. M. A. Shafi, D. Vedage, S. Ghorbhanian, S. Klimach, J. Bradley, E. de Sausmarez, P. Hayward, S. Naqib, C. Flanigan, R. H. A. Shuttleworth, M. Clements, K. McElvanna, B. Shelton, N. Westbrook, A. Weir, P. Webb, M. Alam, S. Bhanderi, C. Roberts, J. Al-Shakarchi, M. Lu, J. Harvey, M. U. Chowdhury, C. McGow, I. Antoniou, D. F. Good, N. Gerasimova, M. Eragat, N. Pressler, C. R. D. Santos, W. Arshad, H. R. Patel, Y. Kassim, S. Shah, N. Jayaratne, A. Perera, L. Chandramoorthy, V. Quan, A. Ponweera, J. Tadjkarimi, L. Moyes, C. Metcalfe, T. Napier-Hemy, A. Bull, M. Elsaddig, Y. Jaffer, J. Mushtaq, M. Warren, Z. Jarrar, R. Wickenden, M. Kang, G. Holohan, T. Isbister, E. Strachan, R. Varma, S. J. Chapman, R. Simpson, N. Rajasekar, H. Panayiotou, E. Walsh, A. Thacoor, J. M. H. Willson, A. Mustafa, I. Barai, A. Menon, W. C. Soon, C. Thakrar, K. Patel, S. McCurdie, E. C. F. Carr, K. J. Westwood, H. Wardell, D. Weinberg, A. R. J. Craig, F. A. S. Khan, A. Mulla, P. Dann, M. Saleh, I. C. Pignatelli, K. V. Igbagiri, E. V. Panagoulas, T. W. Tilston, A. J. Thayaparan, J. Navaratnam, S. Aryasomayajula, N. Joji, R. Screen, C. Quinn, R. Harrison, A. Arnaout, N. McCartan, W. Allen, R. Gabriel, C. F. Hartelius, M. L. Makinde, S. Sivasubramaniam, P. Spreadborough, R. Lobo, H. Surendran, L. Couch, T. Butters, K. Beale, O. Markiewicz, E. D. Kennedy, D. M. Neely, A. Martin, Z. H. Al-Moasseb, K. K. Ong, S. Letchumanan, W. L. Lam, L. Yapp, B. L. Skelly, S. Stallard, P. V. D. Westhuizen, A. R. Rafferty, A. Lambert, Y. Z. Tay, Z. Koshnow, O. Elamin, A. Shah, E. Kim, W. English, A. Farrell, J. Sharma, D. Chudek, K. Rowan, B. Mullan, R. J. Brown, J. A. McCarter, D. Johnston, C. Symonds, W. Gatfield, D. Messenger, J. D. Knox, P. Jani, J. Trinquet, Z. B. Naqvi, K. Hussain, A. Jaffer, E. McAleer, H. Joshi, E. Cecil, A. Lochrane, T. Woolley, P. Marriott, W. Bolton, V. Balian, A. J. Scott, Y. H. Tan

*Corresponding author for this work

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Background: Recent evidence has suggested an association between postoperative non-steroidal anti-inflammatory drugs (NSAIDs) and increased operation-specific complications. This study aimed to determine the safety profile following gastrointestinal surgery across a multicentre setting in the UK.

Methods: This multicentre study was carried out during a 2-week interval in September-October 2013. Consecutive adults undergoing elective or emergency gastrointestinal resection were included. The study was powered to detect a 10 per cent increase in major complications (grade III-V according to the Dindo-Clavien classification). The effect of administration of NSAIDs on the day of surgery or the following 2 days was risk-adjusted using propensity score matching and multivariable logistic regression to produce adjusted odds ratios (ORs). The type of NSAID and the dose were registered.

Results: Across 109 centres, early postoperative NSAIDs were administered to 242 (16.1 per cent) of 1503 patients. Complications occurred in 981 patients (65.3 per cent), which were major in 257 (17.1 per cent) and minor (Dindo-Clavien grade I-II) in 724 (48.2 per cent). Propensity score matching created well balanced groups. Treatment with NSAIDs was associated with a reduction in overall complications (OR 0.72, 95 per cent confidence interval 0.52 to 0.99; P = 0.041). This effect predominately comprised a reduction in minor complications with high-dose NSAIDs (OR 0.57, 0.39 to 0.89; P = 0.009).

Conclusion: Early use of NSAIDs is associated with a reduction in postoperative adverse events following major gastrointestinal surgery.

Original languageEnglish
Pages (from-to)1413-1423
Number of pages11
JournalBritish Journal of Surgery
Volume101
Issue number11
Early online date4 Aug 2014
DOIs
Publication statusPublished - Oct 2014

Keywords

  • anastomotic leakage
  • society recommendations
  • colorectal surgery
  • perioperative care
  • enhanced recovery
  • colonic surgery
  • risk
  • complications
  • guidelines
  • inhibitor

Cite this

Chapman, S. J., Collaborative, STARS., Glasbey, J., Kelly, M., Khatri, C., Nepogodiev, D., ... Tan, Y. H. (2014). Impact of postoperative non-steroidal anti-inflammatory drugs on adverse events after gastrointestinal surgery. British Journal of Surgery, 101(11), 1413-1423. https://doi.org/10.1002/bjs.9614

Impact of postoperative non-steroidal anti-inflammatory drugs on adverse events after gastrointestinal surgery. / Chapman, S. J.; Collaborative, STARSurg; Glasbey, J.; Kelly, M.; Khatri, C.; Nepogodiev, D.; Fitzgerald, J. E. F.; Bhangu, A.; Harrison, E. M.; Adams, R.; Patel, K.; Khatri, C.; Retchless, A. R.; Elsaddig, M.; Curtis, A. E.; Nepogodiev, D.; Glasbey, J.; McMahon, R.; Mittapalli, D.; Ferguson, L. A.; Gentry, S. V.; Kong, C. Y. N.; Naqvi, Z.; Amin, H.; Chapman, S. J.; Kelly, M.; Chaudhry, B.; Burke, J.; Henderson, I.; Trecarten, S.; Clements, J. M.; Drake, T. M.; Wild, J. R. L.; Venkatesh, H.; Butters, N.; Ahmeidat, Hassen; Goergen, N.; Adams, Rachel; Black, Douglas; Robertson, Kim; Jama, G. M.; McGuire, S. A.; Ahl, R.; Suri, T. S.; Kuo, R.; Fadhlillah, M.; Mills, H.; Mitchell, R.; Goodship, J.; Tan, M.; Barker, T.; Wright, T.; Mohamad, W.; Hanna, N.; Laing, G.; Warnock, M. W. C.; Baird-Fraser, P. R.; Logan, T.; Young, F. M.; De Salis, A. C. Fane; McHugh, R.; Drake, T. M.; Hickson, C.; Paszkiewicz, J.; Anderson, L. B.; Neeson, D.; Mohan, M.; Narang, Y.; Brophy, T.; Punj, R.; Majumdar, S.; Kauser, S.; Jong, G.; Palkhi, E.; Finch, D.; Curtis, A. E.; Mitchell, H.; Carter, N.; Viyasar, T.; Sammut, T.; Cook, N.; Powell, M. M.; Horne, S.; Allen, J. L. Y.; Marshall, D.; McIntyre, C.; Koh, D. T. S.; Shi, J.; Reid, T.; Armugam, N. P.; Luck, J.; Fozard, T.; O'Callaghan, J.; Copley, P. C.; Tilliriou, V.; Aiyer, R.; Yazdi, A.; Wiltshire, A.; Blower, E.; Jewitt, C.; Cheung, L. K.; Fourali, S.; Rahimi, Y.; Velho, R.; Taylor, C.; Satterthwaite, L.; Eze, N. V.; Johnston, J. P. M.; McCain, R. S.; Hess, E. C. F.; Thumbadoo, R. P.; Turner, E. J. H.; Wookey, R.; Morris, R.; Gasteratos, K.; Heywood, E.; Simpson, S. J.; Rai, Z.; Kazzazi, D.; Ducey, J.; Livesey, M. J.; Finan, C.; Staunton, E.; Haddad, S. D.; Karanjia, R.; Bokobza, I.; Ahmed, M.; Howell, J.; Adams, R.; Grainger, C.; Woo, A.; McDowall, M.; Bulley, F.; Keating, R.; Tan, B.; Sng, S.; Brown, C.; Aidoo-Micah, G.; Champsi, A.; Ellis, R.; Darwazeh, S.; Polson, R.; Chan, J. Z.; Chong, B. F. H. K.; Park, J. H.; Kong, C. Y.; Mogan, Y. P.; Stevens, S.; Sekhon, H. K.; McIntosh, R.; Ochiltree, D. W.; Jamieson, P. D.; Naumann, D. N.; Bowley, D. M.; Howell, G.; Clark, T.; Dear, K.; James, L.; Upchurch, E.; Wilson, H.; Hughes, M.; Retchless, A. R.; Modayur, S. M.; Naumann, D. N.; Bowley, D. M.; Datta, U.; Chen, J. H. C.; Williams, L. J. L.; Selby, J.; Prabhudesai, A.; Mahomed, K.; Shah, H. A.; Kong, K.; Chandramoorthy, S.; Marshall, L.; De Kauwe, C.; Rana, R.; Patel, J.; Pezas, T.; Ma, J.; Stohlner, V.; Kinsella, M. S.; Gardiner, S. N.; Smith, R. A.; Glover, M.; Akinfala, M.; Lee, J. Z. C.; Aggarwal, V.; Waters, S.; Atif, M.; Hill, M.; Ramasubramoni, A.; Jaffry, Z.; Sagoo, H.; Jeyakumar, J.; Kosasih, S.; Davis, J.; Stanley, G. H. M.; Nijran, J.; Tang, I.; Mehta, K.; Fillery, A.; Watson, N. F.; Shah, D.; Naidu, S.; Grewal, T. K.; Singh, P.; Reissis, D.; Marusza, C.; Luck, J.; Pettit, W.; Timbrell, S.; Woods, R.; Phillips, J.; Vaughan, R.; Dean, S.; Gibby, R.; Jones, T. F.; Rao, R.; Torrance, H. D. T.; Thirumal, V.; McMahon, R. K.; Yap, D.; Mittapalli, D.; Shaw, A.; Claireaux, H. A.; Pang, Y. L.; Narramore, R.; Holmes, C.; Caldwell, A.; Daoub, A.; Bibby, L.; Hague, A. G.; Sykes, M. C.; Patel, K.; Morar, P.; Downes, G.; Shah, S.; Walimohamed, S.; Alsulaimi, A.; Biswas, V.; Gnaneswaran, B.; Davies, N.; Narwani, V.; Nepogodiev, D.; Hernon, J.; Jumbu, A.; Ilyas, M.; Johal, G.; Atia, F.; Williams, A.; Chan, C.; McAnelly, S.; Evans, A.; Chan, K. Y.; Flegg, K.; Carter, S.; Coley, J.; Khaw, R.; Jayakody, N.; Jones, B.; Fawcett, N.; Ghali, C.; Jalundhwala, K.; Ariyaratnam, P.; Colville, H.; Walls, M.; Lindsay, J.; Keane, M.; Ban, S.; Kambasha, C.; Sait, S.; Tahir, M.; Trecarten, S.; Henderson, I.; Tharakan, R.; Voll, J.; Shiwani, H.; Al-Omran, Y.; Hawash, A.; McCaughan, V.; Shatkar, V.; Gohil, K.; Greenhalgh, A.; Higgins, E.; Moody, T.; Booth, M. B.; Chan, W. H.; Shanthakumaran, S.; Maple, N.; McNish, D.; Shahin, B.; Nicholas, J.; McDermid, R.; Narayan, P.; Brodie, C.; Hurrey, S.; Gentry, V.; Panayi, V.; Turner, B.; Kopala, K.; Clayton, S.; Winfield, A.; Mohamud, A.; Venkatesh, A.; Hosein, S.; Olimpio, C.; Gkiousias, V.; Kilgour, J. M.; Cogbill, E.; Ramcharn, M.; Carr, G.; Bannerman, A.; Grundy, L.; White, S.; Beamish, A.; Ferguson, L. A.; Neo, Y. N.; Cragg, A. R.; Harrison, E. M.; Perkins, A.; Wynn-Hebden, A.; Khan, T.; Ali, M.; Battersby, C. L. F.; Pinto, R. S.; Poon, S. S.; Patel, M.; Patel, P.; Shafi, A. M. A.; Vedage, D.; Ghorbhanian, S.; Klimach, S.; Bradley, J.; de Sausmarez, E.; Hayward, P.; Naqib, S.; Flanigan, C.; Shuttleworth, R. H. A.; Clements, M.; McElvanna, K.; Shelton, B.; Westbrook, N.; Weir, A.; Webb, P.; Alam, M.; Bhanderi, S.; Roberts, C.; Al-Shakarchi, J.; Lu, M.; Harvey, J.; Chowdhury, M. U.; McGow, C.; Antoniou, I.; Good, D. F.; Gerasimova, N.; Eragat, M.; Pressler, N.; Santos, C. R. D.; Arshad, W.; Patel, H. R.; Kassim, Y.; Shah, S.; Jayaratne, N.; Perera, A.; Chandramoorthy, L.; Quan, V.; Ponweera, A.; Tadjkarimi, J.; Moyes, L.; Metcalfe, C.; Napier-Hemy, T.; Bull, A.; Elsaddig, M.; Jaffer, Y.; Mushtaq, J.; Warren, M.; Jarrar, Z.; Wickenden, R.; Kang, M.; Holohan, G.; Isbister, T.; Strachan, E.; Varma, R.; Chapman, S. J.; Simpson, R.; Rajasekar, N.; Panayiotou, H.; Walsh, E.; Thacoor, A.; Willson, J. M. H.; Mustafa, A.; Barai, I.; Menon, A.; Soon, W. C.; Thakrar, C.; Patel, K.; McCurdie, S.; Carr, E. C. F.; Westwood, K. J.; Wardell, H.; Weinberg, D.; Craig, A. R. J.; Khan, F. A. S.; Mulla, A.; Dann, P.; Saleh, M.; Pignatelli, I. C.; Igbagiri, K. V.; Panagoulas, E. V.; Tilston, T. W.; Thayaparan, A. J.; Navaratnam, J.; Aryasomayajula, S.; Joji, N.; Screen, R.; Quinn, C.; Harrison, R.; Arnaout, A.; McCartan, N.; Allen, W.; Gabriel, R.; Hartelius, C. F.; Makinde, M. L.; Sivasubramaniam, S.; Spreadborough, P.; Lobo, R.; Surendran, H.; Couch, L.; Butters, T.; Beale, K.; Markiewicz, O.; Kennedy, E. D.; Neely, D. M.; Martin, A.; Al-Moasseb, Z. H.; Ong, K. K.; Letchumanan, S.; Lam, W. L.; Yapp, L.; Skelly, B. L.; Stallard, S.; Westhuizen, P. V. D.; Rafferty, A. R.; Lambert, A.; Tay, Y. Z.; Koshnow, Z.; Elamin, O.; Shah, A.; Kim, E.; English, W.; Farrell, A.; Sharma, J.; Chudek, D.; Rowan, K.; Mullan, B.; Brown, R. J.; McCarter, J. A.; Johnston, D.; Symonds, C.; Gatfield, W.; Messenger, D.; Knox, J. D.; Jani, P.; Trinquet, J.; Naqvi, Z. B.; Hussain, K.; Jaffer, A.; McAleer, E.; Joshi, H.; Cecil, E.; Lochrane, A.; Woolley, T.; Marriott, P.; Bolton, W.; Balian, V.; Scott, A. J.; Tan, Y. H.

In: British Journal of Surgery, Vol. 101, No. 11, 10.2014, p. 1413-1423.

Research output: Contribution to journalArticle

Chapman, SJ, Collaborative, STARS, Glasbey, J, Kelly, M, Khatri, C, Nepogodiev, D, Fitzgerald, JEF, Bhangu, A, Harrison, EM, Adams, R, Patel, K, Khatri, C, Retchless, AR, Elsaddig, M, Curtis, AE, Nepogodiev, D, Glasbey, J, McMahon, R, Mittapalli, D, Ferguson, LA, Gentry, SV, Kong, CYN, Naqvi, Z, Amin, H, Chapman, SJ, Kelly, M, Chaudhry, B, Burke, J, Henderson, I, Trecarten, S, Clements, JM, Drake, TM, Wild, JRL, Venkatesh, H, Butters, N, Ahmeidat, H, Goergen, N, Adams, R, Black, D, Robertson, K, Jama, GM, McGuire, SA, Ahl, R, Suri, TS, Kuo, R, Fadhlillah, M, Mills, H, Mitchell, R, Goodship, J, Tan, M, Barker, T, Wright, T, Mohamad, W, Hanna, N, Laing, G, Warnock, MWC, Baird-Fraser, PR, Logan, T, Young, FM, De Salis, ACF, McHugh, R, Drake, TM, Hickson, C, Paszkiewicz, J, Anderson, LB, Neeson, D, Mohan, M, Narang, Y, Brophy, T, Punj, R, Majumdar, S, Kauser, S, Jong, G, Palkhi, E, Finch, D, Curtis, AE, Mitchell, H, Carter, N, Viyasar, T, Sammut, T, Cook, N, Powell, MM, Horne, S, Allen, JLY, Marshall, D, McIntyre, C, Koh, DTS, Shi, J, Reid, T, Armugam, NP, Luck, J, Fozard, T, O'Callaghan, J, Copley, PC, Tilliriou, V, Aiyer, R, Yazdi, A, Wiltshire, A, Blower, E, Jewitt, C, Cheung, LK, Fourali, S, Rahimi, Y, Velho, R, Taylor, C, Satterthwaite, L, Eze, NV, Johnston, JPM, McCain, RS, Hess, ECF, Thumbadoo, RP, Turner, EJH, Wookey, R, Morris, R, Gasteratos, K, Heywood, E, Simpson, SJ, Rai, Z, Kazzazi, D, Ducey, J, Livesey, MJ, Finan, C, Staunton, E, Haddad, SD, Karanjia, R, Bokobza, I, Ahmed, M, Howell, J, Adams, R, Grainger, C, Woo, A, McDowall, M, Bulley, F, Keating, R, Tan, B, Sng, S, Brown, C, Aidoo-Micah, G, Champsi, A, Ellis, R, Darwazeh, S, Polson, R, Chan, JZ, Chong, BFHK, Park, JH, Kong, CY, Mogan, YP, Stevens, S, Sekhon, HK, McIntosh, R, Ochiltree, DW, Jamieson, PD, Naumann, DN, Bowley, DM, Howell, G, Clark, T, Dear, K, James, L, Upchurch, E, Wilson, H, Hughes, M, Retchless, AR, Modayur, SM, Naumann, DN, Bowley, DM, Datta, U, Chen, JHC, Williams, LJL, Selby, J, Prabhudesai, A, Mahomed, K, Shah, HA, Kong, K, Chandramoorthy, S, Marshall, L, De Kauwe, C, Rana, R, Patel, J, Pezas, T, Ma, J, Stohlner, V, Kinsella, MS, Gardiner, SN, Smith, RA, Glover, M, Akinfala, M, Lee, JZC, Aggarwal, V, Waters, S, Atif, M, Hill, M, Ramasubramoni, A, Jaffry, Z, Sagoo, H, Jeyakumar, J, Kosasih, S, Davis, J, Stanley, GHM, Nijran, J, Tang, I, Mehta, K, Fillery, A, Watson, NF, Shah, D, Naidu, S, Grewal, TK, Singh, P, Reissis, D, Marusza, C, Luck, J, Pettit, W, Timbrell, S, Woods, R, Phillips, J, Vaughan, R, Dean, S, Gibby, R, Jones, TF, Rao, R, Torrance, HDT, Thirumal, V, McMahon, RK, Yap, D, Mittapalli, D, Shaw, A, Claireaux, HA, Pang, YL, Narramore, R, Holmes, C, Caldwell, A, Daoub, A, Bibby, L, Hague, AG, Sykes, MC, Patel, K, Morar, P, Downes, G, Shah, S, Walimohamed, S, Alsulaimi, A, Biswas, V, Gnaneswaran, B, Davies, N, Narwani, V, Nepogodiev, D, Hernon, J, Jumbu, A, Ilyas, M, Johal, G, Atia, F, Williams, A, Chan, C, McAnelly, S, Evans, A, Chan, KY, Flegg, K, Carter, S, Coley, J, Khaw, R, Jayakody, N, Jones, B, Fawcett, N, Ghali, C, Jalundhwala, K, Ariyaratnam, P, Colville, H, Walls, M, Lindsay, J, Keane, M, Ban, S, Kambasha, C, Sait, S, Tahir, M, Trecarten, S, Henderson, I, Tharakan, R, Voll, J, Shiwani, H, Al-Omran, Y, Hawash, A, McCaughan, V, Shatkar, V, Gohil, K, Greenhalgh, A, Higgins, E, Moody, T, Booth, MB, Chan, WH, Shanthakumaran, S, Maple, N, McNish, D, Shahin, B, Nicholas, J, McDermid, R, Narayan, P, Brodie, C, Hurrey, S, Gentry, V, Panayi, V, Turner, B, Kopala, K, Clayton, S, Winfield, A, Mohamud, A, Venkatesh, A, Hosein, S, Olimpio, C, Gkiousias, V, Kilgour, JM, Cogbill, E, Ramcharn, M, Carr, G, Bannerman, A, Grundy, L, White, S, Beamish, A, Ferguson, LA, Neo, YN, Cragg, AR, Harrison, EM, Perkins, A, Wynn-Hebden, A, Khan, T, Ali, M, Battersby, CLF, Pinto, RS, Poon, SS, Patel, M, Patel, P, Shafi, AMA, Vedage, D, Ghorbhanian, S, Klimach, S, Bradley, J, de Sausmarez, E, Hayward, P, Naqib, S, Flanigan, C, Shuttleworth, RHA, Clements, M, McElvanna, K, Shelton, B, Westbrook, N, Weir, A, Webb, P, Alam, M, Bhanderi, S, Roberts, C, Al-Shakarchi, J, Lu, M, Harvey, J, Chowdhury, MU, McGow, C, Antoniou, I, Good, DF, Gerasimova, N, Eragat, M, Pressler, N, Santos, CRD, Arshad, W, Patel, HR, Kassim, Y, Shah, S, Jayaratne, N, Perera, A, Chandramoorthy, L, Quan, V, Ponweera, A, Tadjkarimi, J, Moyes, L, Metcalfe, C, Napier-Hemy, T, Bull, A, Elsaddig, M, Jaffer, Y, Mushtaq, J, Warren, M, Jarrar, Z, Wickenden, R, Kang, M, Holohan, G, Isbister, T, Strachan, E, Varma, R, Chapman, SJ, Simpson, R, Rajasekar, N, Panayiotou, H, Walsh, E, Thacoor, A, Willson, JMH, Mustafa, A, Barai, I, Menon, A, Soon, WC, Thakrar, C, Patel, K, McCurdie, S, Carr, ECF, Westwood, KJ, Wardell, H, Weinberg, D, Craig, ARJ, Khan, FAS, Mulla, A, Dann, P, Saleh, M, Pignatelli, IC, Igbagiri, KV, Panagoulas, EV, Tilston, TW, Thayaparan, AJ, Navaratnam, J, Aryasomayajula, S, Joji, N, Screen, R, Quinn, C, Harrison, R, Arnaout, A, McCartan, N, Allen, W, Gabriel, R, Hartelius, CF, Makinde, ML, Sivasubramaniam, S, Spreadborough, P, Lobo, R, Surendran, H, Couch, L, Butters, T, Beale, K, Markiewicz, O, Kennedy, ED, Neely, DM, Martin, A, Al-Moasseb, ZH, Ong, KK, Letchumanan, S, Lam, WL, Yapp, L, Skelly, BL, Stallard, S, Westhuizen, PVD, Rafferty, AR, Lambert, A, Tay, YZ, Koshnow, Z, Elamin, O, Shah, A, Kim, E, English, W, Farrell, A, Sharma, J, Chudek, D, Rowan, K, Mullan, B, Brown, RJ, McCarter, JA, Johnston, D, Symonds, C, Gatfield, W, Messenger, D, Knox, JD, Jani, P, Trinquet, J, Naqvi, ZB, Hussain, K, Jaffer, A, McAleer, E, Joshi, H, Cecil, E, Lochrane, A, Woolley, T, Marriott, P, Bolton, W, Balian, V, Scott, AJ & Tan, YH 2014, 'Impact of postoperative non-steroidal anti-inflammatory drugs on adverse events after gastrointestinal surgery', British Journal of Surgery, vol. 101, no. 11, pp. 1413-1423. https://doi.org/10.1002/bjs.9614
Chapman SJ, Collaborative STARS, Glasbey J, Kelly M, Khatri C, Nepogodiev D et al. Impact of postoperative non-steroidal anti-inflammatory drugs on adverse events after gastrointestinal surgery. British Journal of Surgery. 2014 Oct;101(11):1413-1423. https://doi.org/10.1002/bjs.9614
Chapman, S. J. ; Collaborative, STARSurg ; Glasbey, J. ; Kelly, M. ; Khatri, C. ; Nepogodiev, D. ; Fitzgerald, J. E. F. ; Bhangu, A. ; Harrison, E. M. ; Adams, R. ; Patel, K. ; Khatri, C. ; Retchless, A. R. ; Elsaddig, M. ; Curtis, A. E. ; Nepogodiev, D. ; Glasbey, J. ; McMahon, R. ; Mittapalli, D. ; Ferguson, L. A. ; Gentry, S. V. ; Kong, C. Y. N. ; Naqvi, Z. ; Amin, H. ; Chapman, S. J. ; Kelly, M. ; Chaudhry, B. ; Burke, J. ; Henderson, I. ; Trecarten, S. ; Clements, J. M. ; Drake, T. M. ; Wild, J. R. L. ; Venkatesh, H. ; Butters, N. ; Ahmeidat, Hassen ; Goergen, N. ; Adams, Rachel ; Black, Douglas ; Robertson, Kim ; Jama, G. M. ; McGuire, S. A. ; Ahl, R. ; Suri, T. S. ; Kuo, R. ; Fadhlillah, M. ; Mills, H. ; Mitchell, R. ; Goodship, J. ; Tan, M. ; Barker, T. ; Wright, T. ; Mohamad, W. ; Hanna, N. ; Laing, G. ; Warnock, M. W. C. ; Baird-Fraser, P. R. ; Logan, T. ; Young, F. M. ; De Salis, A. C. Fane ; McHugh, R. ; Drake, T. M. ; Hickson, C. ; Paszkiewicz, J. ; Anderson, L. B. ; Neeson, D. ; Mohan, M. ; Narang, Y. ; Brophy, T. ; Punj, R. ; Majumdar, S. ; Kauser, S. ; Jong, G. ; Palkhi, E. ; Finch, D. ; Curtis, A. E. ; Mitchell, H. ; Carter, N. ; Viyasar, T. ; Sammut, T. ; Cook, N. ; Powell, M. M. ; Horne, S. ; Allen, J. L. Y. ; Marshall, D. ; McIntyre, C. ; Koh, D. T. S. ; Shi, J. ; Reid, T. ; Armugam, N. P. ; Luck, J. ; Fozard, T. ; O'Callaghan, J. ; Copley, P. C. ; Tilliriou, V. ; Aiyer, R. ; Yazdi, A. ; Wiltshire, A. ; Blower, E. ; Jewitt, C. ; Cheung, L. K. ; Fourali, S. ; Rahimi, Y. ; Velho, R. ; Taylor, C. ; Satterthwaite, L. ; Eze, N. V. ; Johnston, J. P. M. ; McCain, R. S. ; Hess, E. C. F. ; Thumbadoo, R. P. ; Turner, E. J. H. ; Wookey, R. ; Morris, R. ; Gasteratos, K. ; Heywood, E. ; Simpson, S. J. ; Rai, Z. ; Kazzazi, D. ; Ducey, J. ; Livesey, M. J. ; Finan, C. ; Staunton, E. ; Haddad, S. D. ; Karanjia, R. ; Bokobza, I. ; Ahmed, M. ; Howell, J. ; Adams, R. ; Grainger, C. ; Woo, A. ; McDowall, M. ; Bulley, F. ; Keating, R. ; Tan, B. ; Sng, S. ; Brown, C. ; Aidoo-Micah, G. ; Champsi, A. ; Ellis, R. ; Darwazeh, S. ; Polson, R. ; Chan, J. Z. ; Chong, B. F. H. K. ; Park, J. H. ; Kong, C. Y. ; Mogan, Y. P. ; Stevens, S. ; Sekhon, H. K. ; McIntosh, R. ; Ochiltree, D. W. ; Jamieson, P. D. ; Naumann, D. N. ; Bowley, D. M. ; Howell, G. ; Clark, T. ; Dear, K. ; James, L. ; Upchurch, E. ; Wilson, H. ; Hughes, M. ; Retchless, A. R. ; Modayur, S. M. ; Naumann, D. N. ; Bowley, D. M. ; Datta, U. ; Chen, J. H. C. ; Williams, L. J. L. ; Selby, J. ; Prabhudesai, A. ; Mahomed, K. ; Shah, H. A. ; Kong, K. ; Chandramoorthy, S. ; Marshall, L. ; De Kauwe, C. ; Rana, R. ; Patel, J. ; Pezas, T. ; Ma, J. ; Stohlner, V. ; Kinsella, M. S. ; Gardiner, S. N. ; Smith, R. A. ; Glover, M. ; Akinfala, M. ; Lee, J. Z. C. ; Aggarwal, V. ; Waters, S. ; Atif, M. ; Hill, M. ; Ramasubramoni, A. ; Jaffry, Z. ; Sagoo, H. ; Jeyakumar, J. ; Kosasih, S. ; Davis, J. ; Stanley, G. H. M. ; Nijran, J. ; Tang, I. ; Mehta, K. ; Fillery, A. ; Watson, N. F. ; Shah, D. ; Naidu, S. ; Grewal, T. K. ; Singh, P. ; Reissis, D. ; Marusza, C. ; Luck, J. ; Pettit, W. ; Timbrell, S. ; Woods, R. ; Phillips, J. ; Vaughan, R. ; Dean, S. ; Gibby, R. ; Jones, T. F. ; Rao, R. ; Torrance, H. D. T. ; Thirumal, V. ; McMahon, R. K. ; Yap, D. ; Mittapalli, D. ; Shaw, A. ; Claireaux, H. A. ; Pang, Y. L. ; Narramore, R. ; Holmes, C. ; Caldwell, A. ; Daoub, A. ; Bibby, L. ; Hague, A. G. ; Sykes, M. C. ; Patel, K. ; Morar, P. ; Downes, G. ; Shah, S. ; Walimohamed, S. ; Alsulaimi, A. ; Biswas, V. ; Gnaneswaran, B. ; Davies, N. ; Narwani, V. ; Nepogodiev, D. ; Hernon, J. ; Jumbu, A. ; Ilyas, M. ; Johal, G. ; Atia, F. ; Williams, A. ; Chan, C. ; McAnelly, S. ; Evans, A. ; Chan, K. Y. ; Flegg, K. ; Carter, S. ; Coley, J. ; Khaw, R. ; Jayakody, N. ; Jones, B. ; Fawcett, N. ; Ghali, C. ; Jalundhwala, K. ; Ariyaratnam, P. ; Colville, H. ; Walls, M. ; Lindsay, J. ; Keane, M. ; Ban, S. ; Kambasha, C. ; Sait, S. ; Tahir, M. ; Trecarten, S. ; Henderson, I. ; Tharakan, R. ; Voll, J. ; Shiwani, H. ; Al-Omran, Y. ; Hawash, A. ; McCaughan, V. ; Shatkar, V. ; Gohil, K. ; Greenhalgh, A. ; Higgins, E. ; Moody, T. ; Booth, M. B. ; Chan, W. H. ; Shanthakumaran, S. ; Maple, N. ; McNish, D. ; Shahin, B. ; Nicholas, J. ; McDermid, R. ; Narayan, P. ; Brodie, C. ; Hurrey, S. ; Gentry, V. ; Panayi, V. ; Turner, B. ; Kopala, K. ; Clayton, S. ; Winfield, A. ; Mohamud, A. ; Venkatesh, A. ; Hosein, S. ; Olimpio, C. ; Gkiousias, V. ; Kilgour, J. M. ; Cogbill, E. ; Ramcharn, M. ; Carr, G. ; Bannerman, A. ; Grundy, L. ; White, S. ; Beamish, A. ; Ferguson, L. A. ; Neo, Y. N. ; Cragg, A. R. ; Harrison, E. M. ; Perkins, A. ; Wynn-Hebden, A. ; Khan, T. ; Ali, M. ; Battersby, C. L. F. ; Pinto, R. S. ; Poon, S. S. ; Patel, M. ; Patel, P. ; Shafi, A. M. A. ; Vedage, D. ; Ghorbhanian, S. ; Klimach, S. ; Bradley, J. ; de Sausmarez, E. ; Hayward, P. ; Naqib, S. ; Flanigan, C. ; Shuttleworth, R. H. A. ; Clements, M. ; McElvanna, K. ; Shelton, B. ; Westbrook, N. ; Weir, A. ; Webb, P. ; Alam, M. ; Bhanderi, S. ; Roberts, C. ; Al-Shakarchi, J. ; Lu, M. ; Harvey, J. ; Chowdhury, M. U. ; McGow, C. ; Antoniou, I. ; Good, D. F. ; Gerasimova, N. ; Eragat, M. ; Pressler, N. ; Santos, C. R. D. ; Arshad, W. ; Patel, H. R. ; Kassim, Y. ; Shah, S. ; Jayaratne, N. ; Perera, A. ; Chandramoorthy, L. ; Quan, V. ; Ponweera, A. ; Tadjkarimi, J. ; Moyes, L. ; Metcalfe, C. ; Napier-Hemy, T. ; Bull, A. ; Elsaddig, M. ; Jaffer, Y. ; Mushtaq, J. ; Warren, M. ; Jarrar, Z. ; Wickenden, R. ; Kang, M. ; Holohan, G. ; Isbister, T. ; Strachan, E. ; Varma, R. ; Chapman, S. J. ; Simpson, R. ; Rajasekar, N. ; Panayiotou, H. ; Walsh, E. ; Thacoor, A. ; Willson, J. M. H. ; Mustafa, A. ; Barai, I. ; Menon, A. ; Soon, W. C. ; Thakrar, C. ; Patel, K. ; McCurdie, S. ; Carr, E. C. F. ; Westwood, K. J. ; Wardell, H. ; Weinberg, D. ; Craig, A. R. J. ; Khan, F. A. S. ; Mulla, A. ; Dann, P. ; Saleh, M. ; Pignatelli, I. C. ; Igbagiri, K. V. ; Panagoulas, E. V. ; Tilston, T. W. ; Thayaparan, A. J. ; Navaratnam, J. ; Aryasomayajula, S. ; Joji, N. ; Screen, R. ; Quinn, C. ; Harrison, R. ; Arnaout, A. ; McCartan, N. ; Allen, W. ; Gabriel, R. ; Hartelius, C. F. ; Makinde, M. L. ; Sivasubramaniam, S. ; Spreadborough, P. ; Lobo, R. ; Surendran, H. ; Couch, L. ; Butters, T. ; Beale, K. ; Markiewicz, O. ; Kennedy, E. D. ; Neely, D. M. ; Martin, A. ; Al-Moasseb, Z. H. ; Ong, K. K. ; Letchumanan, S. ; Lam, W. L. ; Yapp, L. ; Skelly, B. L. ; Stallard, S. ; Westhuizen, P. V. D. ; Rafferty, A. R. ; Lambert, A. ; Tay, Y. Z. ; Koshnow, Z. ; Elamin, O. ; Shah, A. ; Kim, E. ; English, W. ; Farrell, A. ; Sharma, J. ; Chudek, D. ; Rowan, K. ; Mullan, B. ; Brown, R. J. ; McCarter, J. A. ; Johnston, D. ; Symonds, C. ; Gatfield, W. ; Messenger, D. ; Knox, J. D. ; Jani, P. ; Trinquet, J. ; Naqvi, Z. B. ; Hussain, K. ; Jaffer, A. ; McAleer, E. ; Joshi, H. ; Cecil, E. ; Lochrane, A. ; Woolley, T. ; Marriott, P. ; Bolton, W. ; Balian, V. ; Scott, A. J. ; Tan, Y. H. / Impact of postoperative non-steroidal anti-inflammatory drugs on adverse events after gastrointestinal surgery. In: British Journal of Surgery. 2014 ; Vol. 101, No. 11. pp. 1413-1423.
@article{820716a8000e4754bd0fcc9f0f5edfa8,
title = "Impact of postoperative non-steroidal anti-inflammatory drugs on adverse events after gastrointestinal surgery",
abstract = "Background: Recent evidence has suggested an association between postoperative non-steroidal anti-inflammatory drugs (NSAIDs) and increased operation-specific complications. This study aimed to determine the safety profile following gastrointestinal surgery across a multicentre setting in the UK.Methods: This multicentre study was carried out during a 2-week interval in September-October 2013. Consecutive adults undergoing elective or emergency gastrointestinal resection were included. The study was powered to detect a 10 per cent increase in major complications (grade III-V according to the Dindo-Clavien classification). The effect of administration of NSAIDs on the day of surgery or the following 2 days was risk-adjusted using propensity score matching and multivariable logistic regression to produce adjusted odds ratios (ORs). The type of NSAID and the dose were registered.Results: Across 109 centres, early postoperative NSAIDs were administered to 242 (16.1 per cent) of 1503 patients. Complications occurred in 981 patients (65.3 per cent), which were major in 257 (17.1 per cent) and minor (Dindo-Clavien grade I-II) in 724 (48.2 per cent). Propensity score matching created well balanced groups. Treatment with NSAIDs was associated with a reduction in overall complications (OR 0.72, 95 per cent confidence interval 0.52 to 0.99; P = 0.041). This effect predominately comprised a reduction in minor complications with high-dose NSAIDs (OR 0.57, 0.39 to 0.89; P = 0.009).Conclusion: Early use of NSAIDs is associated with a reduction in postoperative adverse events following major gastrointestinal surgery.",
keywords = "anastomotic leakage, society recommendations, colorectal surgery, perioperative care, enhanced recovery, colonic surgery, risk, complications, guidelines, inhibitor",
author = "Chapman, {S. J.} and STARSurg Collaborative and J. Glasbey and M. Kelly and C. Khatri and D. Nepogodiev and Fitzgerald, {J. E. F.} and A. Bhangu and Harrison, {E. M.} and R. Adams and K. Patel and C. Khatri and Retchless, {A. R.} and M. Elsaddig and Curtis, {A. E.} and D. Nepogodiev and J. Glasbey and R. McMahon and D. Mittapalli and Ferguson, {L. A.} and Gentry, {S. V.} and Kong, {C. Y. N.} and Z. Naqvi and H. Amin and Chapman, {S. J.} and M. Kelly and B. Chaudhry and J. Burke and I. Henderson and S. Trecarten and Clements, {J. M.} and Drake, {T. M.} and Wild, {J. R. L.} and H. Venkatesh and N. Butters and Hassen Ahmeidat and N. Goergen and Rachel Adams and Douglas Black and Kim Robertson and Jama, {G. M.} and McGuire, {S. A.} and R. Ahl and Suri, {T. S.} and R. Kuo and M. Fadhlillah and H. Mills and R. Mitchell and J. Goodship and M. Tan and T. Barker and T. Wright and W. Mohamad and N. Hanna and G. Laing and Warnock, {M. W. C.} and Baird-Fraser, {P. R.} and T. Logan and Young, {F. M.} and {De Salis}, {A. C. Fane} and R. McHugh and Drake, {T. M.} and C. Hickson and J. Paszkiewicz and Anderson, {L. B.} and D. Neeson and M. Mohan and Y. Narang and T. Brophy and R. Punj and S. Majumdar and S. Kauser and G. Jong and E. Palkhi and D. Finch and Curtis, {A. E.} and H. Mitchell and N. Carter and T. Viyasar and T. Sammut and N. Cook and Powell, {M. M.} and S. Horne and Allen, {J. L. Y.} and D. Marshall and C. McIntyre and Koh, {D. T. S.} and J. Shi and T. Reid and Armugam, {N. P.} and J. Luck and T. Fozard and J. O'Callaghan and Copley, {P. C.} and V. Tilliriou and R. Aiyer and A. Yazdi and A. Wiltshire and E. Blower and C. Jewitt and Cheung, {L. K.} and S. Fourali and Y. Rahimi and R. Velho and C. Taylor and L. Satterthwaite and Eze, {N. V.} and Johnston, {J. P. M.} and McCain, {R. S.} and Hess, {E. C. F.} and Thumbadoo, {R. P.} and Turner, {E. J. H.} and R. Wookey and R. Morris and K. Gasteratos and E. Heywood and Simpson, {S. J.} and Z. Rai and D. Kazzazi and J. Ducey and Livesey, {M. J.} and C. Finan and E. Staunton and Haddad, {S. D.} and R. Karanjia and I. Bokobza and M. Ahmed and J. Howell and R. Adams and C. Grainger and A. Woo and M. McDowall and F. Bulley and R. Keating and B. Tan and S. Sng and C. Brown and G. Aidoo-Micah and A. Champsi and R. Ellis and S. Darwazeh and R. Polson and Chan, {J. Z.} and Chong, {B. F. H. K.} and Park, {J. H.} and Kong, {C. Y.} and Mogan, {Y. P.} and S. Stevens and Sekhon, {H. K.} and R. McIntosh and Ochiltree, {D. W.} and Jamieson, {P. D.} and Naumann, {D. N.} and Bowley, {D. M.} and G. Howell and T. Clark and K. Dear and L. James and E. Upchurch and H. Wilson and M. Hughes and Retchless, {A. R.} and Modayur, {S. M.} and Naumann, {D. N.} and Bowley, {D. M.} and U. Datta and Chen, {J. H. C.} and Williams, {L. J. L.} and J. Selby and A. Prabhudesai and K. Mahomed and Shah, {H. A.} and K. Kong and S. Chandramoorthy and L. Marshall and {De Kauwe}, C. and R. Rana and J. Patel and T. Pezas and J. Ma and V. Stohlner and Kinsella, {M. S.} and Gardiner, {S. N.} and Smith, {R. A.} and M. Glover and M. Akinfala and Lee, {J. Z. C.} and V. Aggarwal and S. Waters and M. Atif and M. Hill and A. Ramasubramoni and Z. Jaffry and H. Sagoo and J. Jeyakumar and S. Kosasih and J. Davis and Stanley, {G. H. M.} and J. Nijran and I. Tang and K. Mehta and A. Fillery and Watson, {N. F.} and D. Shah and S. Naidu and Grewal, {T. K.} and P. Singh and D. Reissis and C. Marusza and J. Luck and W. Pettit and S. Timbrell and R. Woods and J. Phillips and R. Vaughan and S. Dean and R. Gibby and Jones, {T. F.} and R. Rao and Torrance, {H. D. T.} and V. Thirumal and McMahon, {R. K.} and D. Yap and D. Mittapalli and A. Shaw and Claireaux, {H. A.} and Pang, {Y. L.} and R. Narramore and C. Holmes and A. Caldwell and A. Daoub and L. Bibby and Hague, {A. G.} and Sykes, {M. C.} and K. Patel and P. Morar and G. Downes and S. Shah and S. Walimohamed and A. Alsulaimi and V. Biswas and B. Gnaneswaran and N. Davies and V. Narwani and D. Nepogodiev and J. Hernon and A. Jumbu and M. Ilyas and G. Johal and F. Atia and A. Williams and C. Chan and S. McAnelly and A. Evans and Chan, {K. Y.} and K. Flegg and S. Carter and J. Coley and R. Khaw and N. Jayakody and B. Jones and N. Fawcett and C. Ghali and K. Jalundhwala and P. Ariyaratnam and H. Colville and M. Walls and J. Lindsay and M. Keane and S. Ban and C. Kambasha and S. Sait and M. Tahir and S. Trecarten and I. Henderson and R. Tharakan and J. Voll and H. Shiwani and Y. Al-Omran and A. Hawash and V. McCaughan and V. Shatkar and K. Gohil and A. Greenhalgh and E. Higgins and T. Moody and Booth, {M. B.} and Chan, {W. H.} and S. Shanthakumaran and N. Maple and D. McNish and B. Shahin and J. Nicholas and R. McDermid and P. Narayan and C. Brodie and S. Hurrey and V. Gentry and V. Panayi and B. Turner and K. Kopala and S. Clayton and A. Winfield and A. Mohamud and A. Venkatesh and S. Hosein and C. Olimpio and V. Gkiousias and Kilgour, {J. M.} and E. Cogbill and M. Ramcharn and G. Carr and A. Bannerman and L. Grundy and S. White and A. Beamish and Ferguson, {L. A.} and Neo, {Y. N.} and Cragg, {A. R.} and Harrison, {E. M.} and A. Perkins and A. Wynn-Hebden and T. Khan and M. Ali and Battersby, {C. L. F.} and Pinto, {R. S.} and Poon, {S. S.} and M. Patel and P. Patel and Shafi, {A. M. A.} and D. Vedage and S. Ghorbhanian and S. Klimach and J. Bradley and {de Sausmarez}, E. and P. Hayward and S. Naqib and C. Flanigan and Shuttleworth, {R. H. A.} and M. Clements and K. McElvanna and B. Shelton and N. Westbrook and A. Weir and P. Webb and M. Alam and S. Bhanderi and C. Roberts and J. Al-Shakarchi and M. Lu and J. Harvey and Chowdhury, {M. U.} and C. McGow and I. Antoniou and Good, {D. F.} and N. Gerasimova and M. Eragat and N. Pressler and Santos, {C. R. D.} and W. Arshad and Patel, {H. R.} and Y. Kassim and S. Shah and N. Jayaratne and A. Perera and L. Chandramoorthy and V. Quan and A. Ponweera and J. Tadjkarimi and L. Moyes and C. Metcalfe and T. Napier-Hemy and A. Bull and M. Elsaddig and Y. Jaffer and J. Mushtaq and M. Warren and Z. Jarrar and R. Wickenden and M. Kang and G. Holohan and T. Isbister and E. Strachan and R. Varma and Chapman, {S. J.} and R. Simpson and N. Rajasekar and H. Panayiotou and E. Walsh and A. Thacoor and Willson, {J. M. H.} and A. Mustafa and I. Barai and A. Menon and Soon, {W. C.} and C. Thakrar and K. Patel and S. McCurdie and Carr, {E. C. F.} and Westwood, {K. J.} and H. Wardell and D. Weinberg and Craig, {A. R. J.} and Khan, {F. A. S.} and A. Mulla and P. Dann and M. Saleh and Pignatelli, {I. C.} and Igbagiri, {K. V.} and Panagoulas, {E. V.} and Tilston, {T. W.} and Thayaparan, {A. J.} and J. Navaratnam and S. Aryasomayajula and N. Joji and R. Screen and C. Quinn and R. Harrison and A. Arnaout and N. McCartan and W. Allen and R. Gabriel and Hartelius, {C. F.} and Makinde, {M. L.} and S. Sivasubramaniam and P. Spreadborough and R. Lobo and H. Surendran and L. Couch and T. Butters and K. Beale and O. Markiewicz and Kennedy, {E. D.} and Neely, {D. M.} and A. Martin and Al-Moasseb, {Z. H.} and Ong, {K. K.} and S. Letchumanan and Lam, {W. L.} and L. Yapp and Skelly, {B. L.} and S. Stallard and Westhuizen, {P. V. D.} and Rafferty, {A. R.} and A. Lambert and Tay, {Y. Z.} and Z. Koshnow and O. Elamin and A. Shah and E. Kim and W. English and A. Farrell and J. Sharma and D. Chudek and K. Rowan and B. Mullan and Brown, {R. J.} and McCarter, {J. A.} and D. Johnston and C. Symonds and W. Gatfield and D. Messenger and Knox, {J. D.} and P. Jani and J. Trinquet and Naqvi, {Z. B.} and K. Hussain and A. Jaffer and E. McAleer and H. Joshi and E. Cecil and A. Lochrane and T. Woolley and P. Marriott and W. Bolton and V. Balian and Scott, {A. J.} and Tan, {Y. H.}",
note = "The Committee thanks all the consultant surgeons who supported and advised the STARSurg teams working in their departments. The Royal College of Surgeons of England provided meeting facilities for a collaborator training day and the Association of Surgeons in Training (http://www.asit.org) supported this meeting with an ASiT Regional Event Grant.",
year = "2014",
month = "10",
doi = "10.1002/bjs.9614",
language = "English",
volume = "101",
pages = "1413--1423",
journal = "British Journal of Surgery",
issn = "0007-1323",
publisher = "British Journal of Surgery",
number = "11",

}

TY - JOUR

T1 - Impact of postoperative non-steroidal anti-inflammatory drugs on adverse events after gastrointestinal surgery

AU - Chapman, S. J.

AU - Collaborative, STARSurg

AU - Glasbey, J.

AU - Kelly, M.

AU - Khatri, C.

AU - Nepogodiev, D.

AU - Fitzgerald, J. E. F.

AU - Bhangu, A.

AU - Harrison, E. M.

AU - Adams, R.

AU - Patel, K.

AU - Khatri, C.

AU - Retchless, A. R.

AU - Elsaddig, M.

AU - Curtis, A. E.

AU - Nepogodiev, D.

AU - Glasbey, J.

AU - McMahon, R.

AU - Mittapalli, D.

AU - Ferguson, L. A.

AU - Gentry, S. V.

AU - Kong, C. Y. N.

AU - Naqvi, Z.

AU - Amin, H.

AU - Chapman, S. J.

AU - Kelly, M.

AU - Chaudhry, B.

AU - Burke, J.

AU - Henderson, I.

AU - Trecarten, S.

AU - Clements, J. M.

AU - Drake, T. M.

AU - Wild, J. R. L.

AU - Venkatesh, H.

AU - Butters, N.

AU - Ahmeidat, Hassen

AU - Goergen, N.

AU - Adams, Rachel

AU - Black, Douglas

AU - Robertson, Kim

AU - Jama, G. M.

AU - McGuire, S. A.

AU - Ahl, R.

AU - Suri, T. S.

AU - Kuo, R.

AU - Fadhlillah, M.

AU - Mills, H.

AU - Mitchell, R.

AU - Goodship, J.

AU - Tan, M.

AU - Barker, T.

AU - Wright, T.

AU - Mohamad, W.

AU - Hanna, N.

AU - Laing, G.

AU - Warnock, M. W. C.

AU - Baird-Fraser, P. R.

AU - Logan, T.

AU - Young, F. M.

AU - De Salis, A. C. Fane

AU - McHugh, R.

AU - Drake, T. M.

AU - Hickson, C.

AU - Paszkiewicz, J.

AU - Anderson, L. B.

AU - Neeson, D.

AU - Mohan, M.

AU - Narang, Y.

AU - Brophy, T.

AU - Punj, R.

AU - Majumdar, S.

AU - Kauser, S.

AU - Jong, G.

AU - Palkhi, E.

AU - Finch, D.

AU - Curtis, A. E.

AU - Mitchell, H.

AU - Carter, N.

AU - Viyasar, T.

AU - Sammut, T.

AU - Cook, N.

AU - Powell, M. M.

AU - Horne, S.

AU - Allen, J. L. Y.

AU - Marshall, D.

AU - McIntyre, C.

AU - Koh, D. T. S.

AU - Shi, J.

AU - Reid, T.

AU - Armugam, N. P.

AU - Luck, J.

AU - Fozard, T.

AU - O'Callaghan, J.

AU - Copley, P. C.

AU - Tilliriou, V.

AU - Aiyer, R.

AU - Yazdi, A.

AU - Wiltshire, A.

AU - Blower, E.

AU - Jewitt, C.

AU - Cheung, L. K.

AU - Fourali, S.

AU - Rahimi, Y.

AU - Velho, R.

AU - Taylor, C.

AU - Satterthwaite, L.

AU - Eze, N. V.

AU - Johnston, J. P. M.

AU - McCain, R. S.

AU - Hess, E. C. F.

AU - Thumbadoo, R. P.

AU - Turner, E. J. H.

AU - Wookey, R.

AU - Morris, R.

AU - Gasteratos, K.

AU - Heywood, E.

AU - Simpson, S. J.

AU - Rai, Z.

AU - Kazzazi, D.

AU - Ducey, J.

AU - Livesey, M. J.

AU - Finan, C.

AU - Staunton, E.

AU - Haddad, S. D.

AU - Karanjia, R.

AU - Bokobza, I.

AU - Ahmed, M.

AU - Howell, J.

AU - Adams, R.

AU - Grainger, C.

AU - Woo, A.

AU - McDowall, M.

AU - Bulley, F.

AU - Keating, R.

AU - Tan, B.

AU - Sng, S.

AU - Brown, C.

AU - Aidoo-Micah, G.

AU - Champsi, A.

AU - Ellis, R.

AU - Darwazeh, S.

AU - Polson, R.

AU - Chan, J. Z.

AU - Chong, B. F. H. K.

AU - Park, J. H.

AU - Kong, C. Y.

AU - Mogan, Y. P.

AU - Stevens, S.

AU - Sekhon, H. K.

AU - McIntosh, R.

AU - Ochiltree, D. W.

AU - Jamieson, P. D.

AU - Naumann, D. N.

AU - Bowley, D. M.

AU - Howell, G.

AU - Clark, T.

AU - Dear, K.

AU - James, L.

AU - Upchurch, E.

AU - Wilson, H.

AU - Hughes, M.

AU - Retchless, A. R.

AU - Modayur, S. M.

AU - Naumann, D. N.

AU - Bowley, D. M.

AU - Datta, U.

AU - Chen, J. H. C.

AU - Williams, L. J. L.

AU - Selby, J.

AU - Prabhudesai, A.

AU - Mahomed, K.

AU - Shah, H. A.

AU - Kong, K.

AU - Chandramoorthy, S.

AU - Marshall, L.

AU - De Kauwe, C.

AU - Rana, R.

AU - Patel, J.

AU - Pezas, T.

AU - Ma, J.

AU - Stohlner, V.

AU - Kinsella, M. S.

AU - Gardiner, S. N.

AU - Smith, R. A.

AU - Glover, M.

AU - Akinfala, M.

AU - Lee, J. Z. C.

AU - Aggarwal, V.

AU - Waters, S.

AU - Atif, M.

AU - Hill, M.

AU - Ramasubramoni, A.

AU - Jaffry, Z.

AU - Sagoo, H.

AU - Jeyakumar, J.

AU - Kosasih, S.

AU - Davis, J.

AU - Stanley, G. H. M.

AU - Nijran, J.

AU - Tang, I.

AU - Mehta, K.

AU - Fillery, A.

AU - Watson, N. F.

AU - Shah, D.

AU - Naidu, S.

AU - Grewal, T. K.

AU - Singh, P.

AU - Reissis, D.

AU - Marusza, C.

AU - Luck, J.

AU - Pettit, W.

AU - Timbrell, S.

AU - Woods, R.

AU - Phillips, J.

AU - Vaughan, R.

AU - Dean, S.

AU - Gibby, R.

AU - Jones, T. F.

AU - Rao, R.

AU - Torrance, H. D. T.

AU - Thirumal, V.

AU - McMahon, R. K.

AU - Yap, D.

AU - Mittapalli, D.

AU - Shaw, A.

AU - Claireaux, H. A.

AU - Pang, Y. L.

AU - Narramore, R.

AU - Holmes, C.

AU - Caldwell, A.

AU - Daoub, A.

AU - Bibby, L.

AU - Hague, A. G.

AU - Sykes, M. C.

AU - Patel, K.

AU - Morar, P.

AU - Downes, G.

AU - Shah, S.

AU - Walimohamed, S.

AU - Alsulaimi, A.

AU - Biswas, V.

AU - Gnaneswaran, B.

AU - Davies, N.

AU - Narwani, V.

AU - Nepogodiev, D.

AU - Hernon, J.

AU - Jumbu, A.

AU - Ilyas, M.

AU - Johal, G.

AU - Atia, F.

AU - Williams, A.

AU - Chan, C.

AU - McAnelly, S.

AU - Evans, A.

AU - Chan, K. Y.

AU - Flegg, K.

AU - Carter, S.

AU - Coley, J.

AU - Khaw, R.

AU - Jayakody, N.

AU - Jones, B.

AU - Fawcett, N.

AU - Ghali, C.

AU - Jalundhwala, K.

AU - Ariyaratnam, P.

AU - Colville, H.

AU - Walls, M.

AU - Lindsay, J.

AU - Keane, M.

AU - Ban, S.

AU - Kambasha, C.

AU - Sait, S.

AU - Tahir, M.

AU - Trecarten, S.

AU - Henderson, I.

AU - Tharakan, R.

AU - Voll, J.

AU - Shiwani, H.

AU - Al-Omran, Y.

AU - Hawash, A.

AU - McCaughan, V.

AU - Shatkar, V.

AU - Gohil, K.

AU - Greenhalgh, A.

AU - Higgins, E.

AU - Moody, T.

AU - Booth, M. B.

AU - Chan, W. H.

AU - Shanthakumaran, S.

AU - Maple, N.

AU - McNish, D.

AU - Shahin, B.

AU - Nicholas, J.

AU - McDermid, R.

AU - Narayan, P.

AU - Brodie, C.

AU - Hurrey, S.

AU - Gentry, V.

AU - Panayi, V.

AU - Turner, B.

AU - Kopala, K.

AU - Clayton, S.

AU - Winfield, A.

AU - Mohamud, A.

AU - Venkatesh, A.

AU - Hosein, S.

AU - Olimpio, C.

AU - Gkiousias, V.

AU - Kilgour, J. M.

AU - Cogbill, E.

AU - Ramcharn, M.

AU - Carr, G.

AU - Bannerman, A.

AU - Grundy, L.

AU - White, S.

AU - Beamish, A.

AU - Ferguson, L. A.

AU - Neo, Y. N.

AU - Cragg, A. R.

AU - Harrison, E. M.

AU - Perkins, A.

AU - Wynn-Hebden, A.

AU - Khan, T.

AU - Ali, M.

AU - Battersby, C. L. F.

AU - Pinto, R. S.

AU - Poon, S. S.

AU - Patel, M.

AU - Patel, P.

AU - Shafi, A. M. A.

AU - Vedage, D.

AU - Ghorbhanian, S.

AU - Klimach, S.

AU - Bradley, J.

AU - de Sausmarez, E.

AU - Hayward, P.

AU - Naqib, S.

AU - Flanigan, C.

AU - Shuttleworth, R. H. A.

AU - Clements, M.

AU - McElvanna, K.

AU - Shelton, B.

AU - Westbrook, N.

AU - Weir, A.

AU - Webb, P.

AU - Alam, M.

AU - Bhanderi, S.

AU - Roberts, C.

AU - Al-Shakarchi, J.

AU - Lu, M.

AU - Harvey, J.

AU - Chowdhury, M. U.

AU - McGow, C.

AU - Antoniou, I.

AU - Good, D. F.

AU - Gerasimova, N.

AU - Eragat, M.

AU - Pressler, N.

AU - Santos, C. R. D.

AU - Arshad, W.

AU - Patel, H. R.

AU - Kassim, Y.

AU - Shah, S.

AU - Jayaratne, N.

AU - Perera, A.

AU - Chandramoorthy, L.

AU - Quan, V.

AU - Ponweera, A.

AU - Tadjkarimi, J.

AU - Moyes, L.

AU - Metcalfe, C.

AU - Napier-Hemy, T.

AU - Bull, A.

AU - Elsaddig, M.

AU - Jaffer, Y.

AU - Mushtaq, J.

AU - Warren, M.

AU - Jarrar, Z.

AU - Wickenden, R.

AU - Kang, M.

AU - Holohan, G.

AU - Isbister, T.

AU - Strachan, E.

AU - Varma, R.

AU - Chapman, S. J.

AU - Simpson, R.

AU - Rajasekar, N.

AU - Panayiotou, H.

AU - Walsh, E.

AU - Thacoor, A.

AU - Willson, J. M. H.

AU - Mustafa, A.

AU - Barai, I.

AU - Menon, A.

AU - Soon, W. C.

AU - Thakrar, C.

AU - Patel, K.

AU - McCurdie, S.

AU - Carr, E. C. F.

AU - Westwood, K. J.

AU - Wardell, H.

AU - Weinberg, D.

AU - Craig, A. R. J.

AU - Khan, F. A. S.

AU - Mulla, A.

AU - Dann, P.

AU - Saleh, M.

AU - Pignatelli, I. C.

AU - Igbagiri, K. V.

AU - Panagoulas, E. V.

AU - Tilston, T. W.

AU - Thayaparan, A. J.

AU - Navaratnam, J.

AU - Aryasomayajula, S.

AU - Joji, N.

AU - Screen, R.

AU - Quinn, C.

AU - Harrison, R.

AU - Arnaout, A.

AU - McCartan, N.

AU - Allen, W.

AU - Gabriel, R.

AU - Hartelius, C. F.

AU - Makinde, M. L.

AU - Sivasubramaniam, S.

AU - Spreadborough, P.

AU - Lobo, R.

AU - Surendran, H.

AU - Couch, L.

AU - Butters, T.

AU - Beale, K.

AU - Markiewicz, O.

AU - Kennedy, E. D.

AU - Neely, D. M.

AU - Martin, A.

AU - Al-Moasseb, Z. H.

AU - Ong, K. K.

AU - Letchumanan, S.

AU - Lam, W. L.

AU - Yapp, L.

AU - Skelly, B. L.

AU - Stallard, S.

AU - Westhuizen, P. V. D.

AU - Rafferty, A. R.

AU - Lambert, A.

AU - Tay, Y. Z.

AU - Koshnow, Z.

AU - Elamin, O.

AU - Shah, A.

AU - Kim, E.

AU - English, W.

AU - Farrell, A.

AU - Sharma, J.

AU - Chudek, D.

AU - Rowan, K.

AU - Mullan, B.

AU - Brown, R. J.

AU - McCarter, J. A.

AU - Johnston, D.

AU - Symonds, C.

AU - Gatfield, W.

AU - Messenger, D.

AU - Knox, J. D.

AU - Jani, P.

AU - Trinquet, J.

AU - Naqvi, Z. B.

AU - Hussain, K.

AU - Jaffer, A.

AU - McAleer, E.

AU - Joshi, H.

AU - Cecil, E.

AU - Lochrane, A.

AU - Woolley, T.

AU - Marriott, P.

AU - Bolton, W.

AU - Balian, V.

AU - Scott, A. J.

AU - Tan, Y. H.

N1 - The Committee thanks all the consultant surgeons who supported and advised the STARSurg teams working in their departments. The Royal College of Surgeons of England provided meeting facilities for a collaborator training day and the Association of Surgeons in Training (http://www.asit.org) supported this meeting with an ASiT Regional Event Grant.

PY - 2014/10

Y1 - 2014/10

N2 - Background: Recent evidence has suggested an association between postoperative non-steroidal anti-inflammatory drugs (NSAIDs) and increased operation-specific complications. This study aimed to determine the safety profile following gastrointestinal surgery across a multicentre setting in the UK.Methods: This multicentre study was carried out during a 2-week interval in September-October 2013. Consecutive adults undergoing elective or emergency gastrointestinal resection were included. The study was powered to detect a 10 per cent increase in major complications (grade III-V according to the Dindo-Clavien classification). The effect of administration of NSAIDs on the day of surgery or the following 2 days was risk-adjusted using propensity score matching and multivariable logistic regression to produce adjusted odds ratios (ORs). The type of NSAID and the dose were registered.Results: Across 109 centres, early postoperative NSAIDs were administered to 242 (16.1 per cent) of 1503 patients. Complications occurred in 981 patients (65.3 per cent), which were major in 257 (17.1 per cent) and minor (Dindo-Clavien grade I-II) in 724 (48.2 per cent). Propensity score matching created well balanced groups. Treatment with NSAIDs was associated with a reduction in overall complications (OR 0.72, 95 per cent confidence interval 0.52 to 0.99; P = 0.041). This effect predominately comprised a reduction in minor complications with high-dose NSAIDs (OR 0.57, 0.39 to 0.89; P = 0.009).Conclusion: Early use of NSAIDs is associated with a reduction in postoperative adverse events following major gastrointestinal surgery.

AB - Background: Recent evidence has suggested an association between postoperative non-steroidal anti-inflammatory drugs (NSAIDs) and increased operation-specific complications. This study aimed to determine the safety profile following gastrointestinal surgery across a multicentre setting in the UK.Methods: This multicentre study was carried out during a 2-week interval in September-October 2013. Consecutive adults undergoing elective or emergency gastrointestinal resection were included. The study was powered to detect a 10 per cent increase in major complications (grade III-V according to the Dindo-Clavien classification). The effect of administration of NSAIDs on the day of surgery or the following 2 days was risk-adjusted using propensity score matching and multivariable logistic regression to produce adjusted odds ratios (ORs). The type of NSAID and the dose were registered.Results: Across 109 centres, early postoperative NSAIDs were administered to 242 (16.1 per cent) of 1503 patients. Complications occurred in 981 patients (65.3 per cent), which were major in 257 (17.1 per cent) and minor (Dindo-Clavien grade I-II) in 724 (48.2 per cent). Propensity score matching created well balanced groups. Treatment with NSAIDs was associated with a reduction in overall complications (OR 0.72, 95 per cent confidence interval 0.52 to 0.99; P = 0.041). This effect predominately comprised a reduction in minor complications with high-dose NSAIDs (OR 0.57, 0.39 to 0.89; P = 0.009).Conclusion: Early use of NSAIDs is associated with a reduction in postoperative adverse events following major gastrointestinal surgery.

KW - anastomotic leakage

KW - society recommendations

KW - colorectal surgery

KW - perioperative care

KW - enhanced recovery

KW - colonic surgery

KW - risk

KW - complications

KW - guidelines

KW - inhibitor

U2 - 10.1002/bjs.9614

DO - 10.1002/bjs.9614

M3 - Article

VL - 101

SP - 1413

EP - 1423

JO - British Journal of Surgery

JF - British Journal of Surgery

SN - 0007-1323

IS - 11

ER -