Impact of Rhinitis on Work Productivity: A Systematic Review

Olivier Vandenplas*, Denis Vinnikov, Paul D. Blanc, Ioana Agache, Claus Bachert, Michael Bewick, Lars Olaf Cardell, Paul Cullinan, Pascal Demoly, Alexis Descatha, Joao Fonseca, Tari Haahtela, Peter W. Hellings, Jacques Jamart, Juha Jantunen, Ömer Kalayci, David Price, Boleslaw Samolinski, Joaquin Sastre, Longxiu TianAntonio L. Valero, Xinyi Zhang, Jean Bousquet

*Corresponding author for this work

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: Allergic rhinitis (AR) is increasingly acknowledged as having a substantial socioeconomic impact associated with impaired work productivity, although available information remains fragmented. Objective: This systematic review summarizes recently available information to provide a quantitative estimate of the burden of AR on work productivity including lost work time (ie, absenteeism) and reduced performance while working (ie, presenteeism). Methods: A Medline search retrieved original studies from 2005 to 2015 pertaining to the impact of AR on work productivity. A pooled analysis of results was carried out with studies reporting data collected through the validated Work Productivity and Activity Impairment (WPAI) questionnaire. Results: The search identified 19 observational surveys and 9 interventional studies. Six studies reported economic evaluations. Pooled analysis of WPAI-based studies found an estimated 3.6% (95% confidence interval [CI], 2.4; 4.8%) missed work time and 35.9% (95% CI, 29.7; 42.1%) had impairment in at-work performance due to AR. Economic evaluations indicated that indirect costs associated with lost work productivity are the principal contributor to the total AR costs and result mainly from impaired presenteeism. The severity of AR symptoms was the most consistent disease-related factor associated with a greater impact of AR on work productivity, although ocular symptoms and sleep disturbances may independently affect work productivity. Overall, the pharmacologic treatment of AR showed a beneficial effect on work productivity. Conclusions: This systematic review provides summary estimates of the magnitude of work productivity impairment due to AR and identifies its main determinant factors. This information may help guide both clinicians and health policy makers.

Original languageEnglish
Pages (from-to)1274-1286
Number of pages13
JournalJournal of Allergy and Clinical Immunology: In Practice
Volume6
Issue number4
Early online date7 Oct 2017
DOIs
Publication statusPublished - 30 Jul 2018

Fingerprint

Rhinitis
Efficiency
Cost-Benefit Analysis
Confidence Intervals
Allergic Rhinitis
Costs and Cost Analysis
Absenteeism
Health Policy
Administrative Personnel
Sleep
Research Design

Keywords

  • Absenteeism
  • Allergy
  • Presenteeism
  • Rhinitis
  • Work productivity

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Vandenplas, O., Vinnikov, D., Blanc, P. D., Agache, I., Bachert, C., Bewick, M., ... Bousquet, J. (2018). Impact of Rhinitis on Work Productivity: A Systematic Review. Journal of Allergy and Clinical Immunology: In Practice, 6(4), 1274-1286. https://doi.org/10.1016/j.jaip.2017.09.002

Impact of Rhinitis on Work Productivity : A Systematic Review. / Vandenplas, Olivier; Vinnikov, Denis; Blanc, Paul D.; Agache, Ioana; Bachert, Claus; Bewick, Michael; Cardell, Lars Olaf; Cullinan, Paul; Demoly, Pascal; Descatha, Alexis; Fonseca, Joao; Haahtela, Tari; Hellings, Peter W.; Jamart, Jacques; Jantunen, Juha; Kalayci, Ömer; Price, David; Samolinski, Boleslaw; Sastre, Joaquin; Tian, Longxiu; Valero, Antonio L.; Zhang, Xinyi; Bousquet, Jean.

In: Journal of Allergy and Clinical Immunology: In Practice, Vol. 6, No. 4, 30.07.2018, p. 1274-1286.

Research output: Contribution to journalArticle

Vandenplas, O, Vinnikov, D, Blanc, PD, Agache, I, Bachert, C, Bewick, M, Cardell, LO, Cullinan, P, Demoly, P, Descatha, A, Fonseca, J, Haahtela, T, Hellings, PW, Jamart, J, Jantunen, J, Kalayci, Ö, Price, D, Samolinski, B, Sastre, J, Tian, L, Valero, AL, Zhang, X & Bousquet, J 2018, 'Impact of Rhinitis on Work Productivity: A Systematic Review', Journal of Allergy and Clinical Immunology: In Practice, vol. 6, no. 4, pp. 1274-1286. https://doi.org/10.1016/j.jaip.2017.09.002
Vandenplas O, Vinnikov D, Blanc PD, Agache I, Bachert C, Bewick M et al. Impact of Rhinitis on Work Productivity: A Systematic Review. Journal of Allergy and Clinical Immunology: In Practice. 2018 Jul 30;6(4):1274-1286. https://doi.org/10.1016/j.jaip.2017.09.002
Vandenplas, Olivier ; Vinnikov, Denis ; Blanc, Paul D. ; Agache, Ioana ; Bachert, Claus ; Bewick, Michael ; Cardell, Lars Olaf ; Cullinan, Paul ; Demoly, Pascal ; Descatha, Alexis ; Fonseca, Joao ; Haahtela, Tari ; Hellings, Peter W. ; Jamart, Jacques ; Jantunen, Juha ; Kalayci, Ömer ; Price, David ; Samolinski, Boleslaw ; Sastre, Joaquin ; Tian, Longxiu ; Valero, Antonio L. ; Zhang, Xinyi ; Bousquet, Jean. / Impact of Rhinitis on Work Productivity : A Systematic Review. In: Journal of Allergy and Clinical Immunology: In Practice. 2018 ; Vol. 6, No. 4. pp. 1274-1286.
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AU - Vandenplas, Olivier

AU - Vinnikov, Denis

AU - Blanc, Paul D.

AU - Agache, Ioana

AU - Bachert, Claus

AU - Bewick, Michael

AU - Cardell, Lars Olaf

AU - Cullinan, Paul

AU - Demoly, Pascal

AU - Descatha, Alexis

AU - Fonseca, Joao

AU - Haahtela, Tari

AU - Hellings, Peter W.

AU - Jamart, Jacques

AU - Jantunen, Juha

AU - Kalayci, Ömer

AU - Price, David

AU - Samolinski, Boleslaw

AU - Sastre, Joaquin

AU - Tian, Longxiu

AU - Valero, Antonio L.

AU - Zhang, Xinyi

AU - Bousquet, Jean

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N2 - Background: Allergic rhinitis (AR) is increasingly acknowledged as having a substantial socioeconomic impact associated with impaired work productivity, although available information remains fragmented. Objective: This systematic review summarizes recently available information to provide a quantitative estimate of the burden of AR on work productivity including lost work time (ie, absenteeism) and reduced performance while working (ie, presenteeism). Methods: A Medline search retrieved original studies from 2005 to 2015 pertaining to the impact of AR on work productivity. A pooled analysis of results was carried out with studies reporting data collected through the validated Work Productivity and Activity Impairment (WPAI) questionnaire. Results: The search identified 19 observational surveys and 9 interventional studies. Six studies reported economic evaluations. Pooled analysis of WPAI-based studies found an estimated 3.6% (95% confidence interval [CI], 2.4; 4.8%) missed work time and 35.9% (95% CI, 29.7; 42.1%) had impairment in at-work performance due to AR. Economic evaluations indicated that indirect costs associated with lost work productivity are the principal contributor to the total AR costs and result mainly from impaired presenteeism. The severity of AR symptoms was the most consistent disease-related factor associated with a greater impact of AR on work productivity, although ocular symptoms and sleep disturbances may independently affect work productivity. Overall, the pharmacologic treatment of AR showed a beneficial effect on work productivity. Conclusions: This systematic review provides summary estimates of the magnitude of work productivity impairment due to AR and identifies its main determinant factors. This information may help guide both clinicians and health policy makers.

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