Impact of Short Term Consumption of Diets High in Either Non-Starch Polysaccharides or Resistant Starch in Comparison with Moderate Weight Loss on Indices of Insulin Sensitivity in Subjects with Metabolic Syndrome

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Abstract

This study investigated if additional non-starch polysaccharide (NSP) or resistant starch (RS), above that currently recommended, leads to better improvement in insulin sensitivity (IS) than observed with modest weight loss (WL). Obese male volunteers (n = 14) were given an energy-maintenance (M) diet containing 27 g NSP and 5 g RS daily for one week. They then received, in a cross-over design, energy-maintenance intakes of either an NSP-enriched diet (42 g NSP, 2.5 g RS) or an RS-enriched diet (16 g NSP, 25 g RS), each for three weeks. Finally, a high protein (30% calories) WL diet was provided at 8 MJ/day for three weeks. During each dietary intervention, endogenous glucose production (EGP) and IS were assessed. Fasting glycaemia was unaltered by diet, but plasma insulin and C-peptide both decreased with the WL diet (p < 0.001), as did EGP (-11%, p = 0.006). Homeostatis model assessment of insulin resistance improved following both WL (p < 0.001) and RS (p < 0.05) diets. Peripheral tissue IS improved only with WL (57%-83%, p < 0.005). Inclusion of additional RS or NSP above amounts currently recommended resulted in little or no improvement in glycaemic control, whereas moderate WL (approximately 3 kg fat) improved IS.

Original languageEnglish
Pages (from-to)2144-2172
Number of pages29
JournalNutrients
Volume5
Issue number6
Early online date10 Jun 2013
DOIs
Publication statusPublished - Jun 2013

Fingerprint

resistant starch
metabolic syndrome
insulin resistance
Starch
Polysaccharides
Insulin Resistance
Weight Loss
weight loss
polysaccharides
Diet
diet
Reducing Diet
Maintenance
Glucose
glycemic control
glucose
C-Peptide
energy
Energy Intake
Cross-Over Studies

Keywords

  • Insulin sensitivity
  • Metabolic syndrome
  • Minimal models
  • Non-starch polysaccharides
  • Resistant starch
  • Stable isotope kinetics
  • Weight loss

ASJC Scopus subject areas

  • Food Science

Cite this

@article{4bd2dc3221e0495d86fbe7241211e0c3,
title = "Impact of Short Term Consumption of Diets High in Either Non-Starch Polysaccharides or Resistant Starch in Comparison with Moderate Weight Loss on Indices of Insulin Sensitivity in Subjects with Metabolic Syndrome",
abstract = "This study investigated if additional non-starch polysaccharide (NSP) or resistant starch (RS), above that currently recommended, leads to better improvement in insulin sensitivity (IS) than observed with modest weight loss (WL). Obese male volunteers (n = 14) were given an energy-maintenance (M) diet containing 27 g NSP and 5 g RS daily for one week. They then received, in a cross-over design, energy-maintenance intakes of either an NSP-enriched diet (42 g NSP, 2.5 g RS) or an RS-enriched diet (16 g NSP, 25 g RS), each for three weeks. Finally, a high protein (30{\%} calories) WL diet was provided at 8 MJ/day for three weeks. During each dietary intervention, endogenous glucose production (EGP) and IS were assessed. Fasting glycaemia was unaltered by diet, but plasma insulin and C-peptide both decreased with the WL diet (p < 0.001), as did EGP (-11{\%}, p = 0.006). Homeostatis model assessment of insulin resistance improved following both WL (p < 0.001) and RS (p < 0.05) diets. Peripheral tissue IS improved only with WL (57{\%}-83{\%}, p < 0.005). Inclusion of additional RS or NSP above amounts currently recommended resulted in little or no improvement in glycaemic control, whereas moderate WL (approximately 3 kg fat) improved IS.",
keywords = "Insulin sensitivity, Metabolic syndrome, Minimal models, Non-starch polysaccharides, Resistant starch, Stable isotope kinetics, Weight loss",
author = "Lobley, {Gerald E.} and Grietje Holtrop and Bremner, {David M.} and Calder, {A. Graham} and Eric Milne and Johnstone, {Alexandra M.}",
note = "This work was partly funded by the World Cancer Research Fund and the Rural and Environmental Research and Analysis Directorate (RERAD) of the Scottish Government as part of the base allocations to both the Rowett Institute of Nutrition and Health (University of Aberdeen) and Biomathematics and Statistics Scotland.",
year = "2013",
month = "6",
doi = "10.3390/nu5062144",
language = "English",
volume = "5",
pages = "2144--2172",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "6",

}

TY - JOUR

T1 - Impact of Short Term Consumption of Diets High in Either Non-Starch Polysaccharides or Resistant Starch in Comparison with Moderate Weight Loss on Indices of Insulin Sensitivity in Subjects with Metabolic Syndrome

AU - Lobley, Gerald E.

AU - Holtrop, Grietje

AU - Bremner, David M.

AU - Calder, A. Graham

AU - Milne, Eric

AU - Johnstone, Alexandra M.

N1 - This work was partly funded by the World Cancer Research Fund and the Rural and Environmental Research and Analysis Directorate (RERAD) of the Scottish Government as part of the base allocations to both the Rowett Institute of Nutrition and Health (University of Aberdeen) and Biomathematics and Statistics Scotland.

PY - 2013/6

Y1 - 2013/6

N2 - This study investigated if additional non-starch polysaccharide (NSP) or resistant starch (RS), above that currently recommended, leads to better improvement in insulin sensitivity (IS) than observed with modest weight loss (WL). Obese male volunteers (n = 14) were given an energy-maintenance (M) diet containing 27 g NSP and 5 g RS daily for one week. They then received, in a cross-over design, energy-maintenance intakes of either an NSP-enriched diet (42 g NSP, 2.5 g RS) or an RS-enriched diet (16 g NSP, 25 g RS), each for three weeks. Finally, a high protein (30% calories) WL diet was provided at 8 MJ/day for three weeks. During each dietary intervention, endogenous glucose production (EGP) and IS were assessed. Fasting glycaemia was unaltered by diet, but plasma insulin and C-peptide both decreased with the WL diet (p < 0.001), as did EGP (-11%, p = 0.006). Homeostatis model assessment of insulin resistance improved following both WL (p < 0.001) and RS (p < 0.05) diets. Peripheral tissue IS improved only with WL (57%-83%, p < 0.005). Inclusion of additional RS or NSP above amounts currently recommended resulted in little or no improvement in glycaemic control, whereas moderate WL (approximately 3 kg fat) improved IS.

AB - This study investigated if additional non-starch polysaccharide (NSP) or resistant starch (RS), above that currently recommended, leads to better improvement in insulin sensitivity (IS) than observed with modest weight loss (WL). Obese male volunteers (n = 14) were given an energy-maintenance (M) diet containing 27 g NSP and 5 g RS daily for one week. They then received, in a cross-over design, energy-maintenance intakes of either an NSP-enriched diet (42 g NSP, 2.5 g RS) or an RS-enriched diet (16 g NSP, 25 g RS), each for three weeks. Finally, a high protein (30% calories) WL diet was provided at 8 MJ/day for three weeks. During each dietary intervention, endogenous glucose production (EGP) and IS were assessed. Fasting glycaemia was unaltered by diet, but plasma insulin and C-peptide both decreased with the WL diet (p < 0.001), as did EGP (-11%, p = 0.006). Homeostatis model assessment of insulin resistance improved following both WL (p < 0.001) and RS (p < 0.05) diets. Peripheral tissue IS improved only with WL (57%-83%, p < 0.005). Inclusion of additional RS or NSP above amounts currently recommended resulted in little or no improvement in glycaemic control, whereas moderate WL (approximately 3 kg fat) improved IS.

KW - Insulin sensitivity

KW - Metabolic syndrome

KW - Minimal models

KW - Non-starch polysaccharides

KW - Resistant starch

KW - Stable isotope kinetics

KW - Weight loss

UR - http://www.scopus.com/inward/record.url?scp=84878980971&partnerID=8YFLogxK

U2 - 10.3390/nu5062144

DO - 10.3390/nu5062144

M3 - Article

VL - 5

SP - 2144

EP - 2172

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 6

ER -