Abstract
This study investigated if additional non-starch polysaccharide (NSP) or resistant starch (RS), above that currently recommended, leads to better improvement in insulin sensitivity (IS) than observed with modest weight loss (WL). Obese male volunteers (n = 14) were given an energy-maintenance (M) diet containing 27 g NSP and 5 g RS daily for one week. They then received, in a cross-over design, energy-maintenance intakes of either an NSP-enriched diet (42 g NSP, 2.5 g RS) or an RS-enriched diet (16 g NSP, 25 g RS), each for three weeks. Finally, a high protein (30% calories) WL diet was provided at 8 MJ/day for three weeks. During each dietary intervention, endogenous glucose production (EGP) and IS were assessed. Fasting glycaemia was unaltered by diet, but plasma insulin and C-peptide both decreased with the WL diet (p < 0.001), as did EGP (-11%, p = 0.006). Homeostatis model assessment of insulin resistance improved following both WL (p < 0.001) and RS (p < 0.05) diets. Peripheral tissue IS improved only with WL (57%-83%, p < 0.005). Inclusion of additional RS or NSP above amounts currently recommended resulted in little or no improvement in glycaemic control, whereas moderate WL (approximately 3 kg fat) improved IS.
| Original language | English |
|---|---|
| Pages (from-to) | 2144-2172 |
| Number of pages | 29 |
| Journal | Nutrients |
| Volume | 5 |
| Issue number | 6 |
| Early online date | 10 Jun 2013 |
| DOIs | |
| Publication status | Published - Jun 2013 |
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Keywords
- Insulin sensitivity
- Metabolic syndrome
- Minimal models
- Non-starch polysaccharides
- Resistant starch
- Stable isotope kinetics
- Weight loss
ASJC Scopus subject areas
- Food Science
Cite this
Impact of Short Term Consumption of Diets High in Either Non-Starch Polysaccharides or Resistant Starch in Comparison with Moderate Weight Loss on Indices of Insulin Sensitivity in Subjects with Metabolic Syndrome. / Lobley, Gerald E.; Holtrop, Grietje; Bremner, David M.; Calder, A. Graham; Milne, Eric; Johnstone, Alexandra M.
In: Nutrients, Vol. 5, No. 6, 06.2013, p. 2144-2172.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact of Short Term Consumption of Diets High in Either Non-Starch Polysaccharides or Resistant Starch in Comparison with Moderate Weight Loss on Indices of Insulin Sensitivity in Subjects with Metabolic Syndrome
AU - Lobley, Gerald E.
AU - Holtrop, Grietje
AU - Bremner, David M.
AU - Calder, A. Graham
AU - Milne, Eric
AU - Johnstone, Alexandra M.
N1 - This work was partly funded by the World Cancer Research Fund and the Rural and Environmental Research and Analysis Directorate (RERAD) of the Scottish Government as part of the base allocations to both the Rowett Institute of Nutrition and Health (University of Aberdeen) and Biomathematics and Statistics Scotland.
PY - 2013/6
Y1 - 2013/6
N2 - This study investigated if additional non-starch polysaccharide (NSP) or resistant starch (RS), above that currently recommended, leads to better improvement in insulin sensitivity (IS) than observed with modest weight loss (WL). Obese male volunteers (n = 14) were given an energy-maintenance (M) diet containing 27 g NSP and 5 g RS daily for one week. They then received, in a cross-over design, energy-maintenance intakes of either an NSP-enriched diet (42 g NSP, 2.5 g RS) or an RS-enriched diet (16 g NSP, 25 g RS), each for three weeks. Finally, a high protein (30% calories) WL diet was provided at 8 MJ/day for three weeks. During each dietary intervention, endogenous glucose production (EGP) and IS were assessed. Fasting glycaemia was unaltered by diet, but plasma insulin and C-peptide both decreased with the WL diet (p < 0.001), as did EGP (-11%, p = 0.006). Homeostatis model assessment of insulin resistance improved following both WL (p < 0.001) and RS (p < 0.05) diets. Peripheral tissue IS improved only with WL (57%-83%, p < 0.005). Inclusion of additional RS or NSP above amounts currently recommended resulted in little or no improvement in glycaemic control, whereas moderate WL (approximately 3 kg fat) improved IS.
AB - This study investigated if additional non-starch polysaccharide (NSP) or resistant starch (RS), above that currently recommended, leads to better improvement in insulin sensitivity (IS) than observed with modest weight loss (WL). Obese male volunteers (n = 14) were given an energy-maintenance (M) diet containing 27 g NSP and 5 g RS daily for one week. They then received, in a cross-over design, energy-maintenance intakes of either an NSP-enriched diet (42 g NSP, 2.5 g RS) or an RS-enriched diet (16 g NSP, 25 g RS), each for three weeks. Finally, a high protein (30% calories) WL diet was provided at 8 MJ/day for three weeks. During each dietary intervention, endogenous glucose production (EGP) and IS were assessed. Fasting glycaemia was unaltered by diet, but plasma insulin and C-peptide both decreased with the WL diet (p < 0.001), as did EGP (-11%, p = 0.006). Homeostatis model assessment of insulin resistance improved following both WL (p < 0.001) and RS (p < 0.05) diets. Peripheral tissue IS improved only with WL (57%-83%, p < 0.005). Inclusion of additional RS or NSP above amounts currently recommended resulted in little or no improvement in glycaemic control, whereas moderate WL (approximately 3 kg fat) improved IS.
KW - Insulin sensitivity
KW - Metabolic syndrome
KW - Minimal models
KW - Non-starch polysaccharides
KW - Resistant starch
KW - Stable isotope kinetics
KW - Weight loss
UR - http://www.scopus.com/inward/record.url?scp=84878980971&partnerID=8YFLogxK
U2 - 10.3390/nu5062144
DO - 10.3390/nu5062144
M3 - Article
C2 - 23752495
AN - SCOPUS:84878980971
VL - 5
SP - 2144
EP - 2172
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 6
ER -