Impact of the Environment upon the Candida albicans Cell Wall and Resultant Effects upon Immune Surveillance

Delma S Childers; Gabriela M Avelar; Judith M Bain; Daniel E Larcombe; Arnab Pradhan; Susan Budge; Helen Heaney; Alistair J P Brown

doi:10.1007/82_2019_182

Impact of the Environment upon the Candida albicans Cell Wall and Resultant Effects upon Immune Surveillance

Delma S Childers, Gabriela M Avelar, Judith M Bain, Daniel E Larcombe, Arnab Pradhan, Susan Budge, Helen Heaney, Alistair J P Brown

University of Exeter

Research output: Chapter in Book/Report/Conference proceeding › Chapter

16 Citations (Scopus)

11 Downloads (Pure)

Abstract

The fungal cell wall is an essential organelle that maintains cellular morphology and protects the fungus from environmental insults. For fungal pathogens such as Candida albicans, it provides a degree of protection against attack by host immune defences. However, the cell wall also presents key epitopes that trigger host immunity and attractive targets for antifungal drugs. Rather than being a rigid shield, it has become clear that the fungal cell wall is an elastic organelle that permits rapid changes in cell volume and the transit of large liposomal particles such as extracellular vesicles. The fungal cell wall is also flexible in that it adapts to local environmental inputs, thereby enhancing the fitness of the fungus in these microenvironments. Recent evidence indicates that this cell wall adaptation affects host-fungus interactions by altering the exposure of major cell wall epitopes that are recognised by innate immune cells. Therefore, we discuss the impact of environmental adaptation upon fungal cell wall structure, and how this affects immune recognition, focussing on C. albicans and drawing parallels with other fungal pathogens.

Original language	English
Title of host publication	The Fungal Cell Wall
Subtitle of host publication	An Armour and a Weapon for Human Fungal Pathogens
Editors	Jean-Paul Latge
Publisher	Springer
Pages	297-330
Number of pages	34
Volume	425
DOIs	https://doi.org/10.1007/82_2019_182
Publication status	Published - 2020

Publication series

Name	Current Topics in Microbiology and Immunology
Publisher	Springer
ISSN (Print)	0070-217X

Bibliographical note

Acknowledgements
This work was funded by a programme grant from the UK Medical Research Council [www.mrc.ac.uk: MR/M026663/1], and by PhD studentships from the University of Aberdeen to AP, DL. The work was also supported by the Medical Research Council Centre for Medical Mycology (MR/N006364/1) and by the Wellcome Trust [www.wellcome.ac.uk: 097377]. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.

Keywords

Candida albicans
Cell wall adaptation
Cell wall signalling
Cell wall structure
Host-fungus interactions
Immune evasion
Candidiasis/immunology
Humans
Candida albicans/cytology
Cell Wall/immunology

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This is a post-peer-review, pre-copyedit version of an article published in Current Topics in Microbiology and Immunology. The final authenticated version is available online at: https://doi.org/10.1007/82_2019_182
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Cite this

Childers, D. S., Avelar, G. M., Bain, J. M., Larcombe, D. E., Pradhan, A., Budge, S., Heaney, H., & Brown, A. J. P. (2020). Impact of the Environment upon the Candida albicans Cell Wall and Resultant Effects upon Immune Surveillance. In J.-P. Latge (Ed.), The Fungal Cell Wall: An Armour and a Weapon for Human Fungal Pathogens (Vol. 425, pp. 297-330). (Current Topics in Microbiology and Immunology). Springer . https://doi.org/10.1007/82_2019_182

Impact of the Environment upon the Candida albicans Cell Wall and Resultant Effects upon Immune Surveillance. / Childers, Delma S; Avelar, Gabriela M; Bain, Judith M et al.
The Fungal Cell Wall: An Armour and a Weapon for Human Fungal Pathogens. ed. / Jean-Paul Latge. Vol. 425 Springer , 2020. p. 297-330 (Current Topics in Microbiology and Immunology).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Childers, DS, Avelar, GM, Bain, JM, Larcombe, DE, Pradhan, A, Budge, S, Heaney, H & Brown, AJP 2020, Impact of the Environment upon the Candida albicans Cell Wall and Resultant Effects upon Immune Surveillance. in J-P Latge (ed.), The Fungal Cell Wall: An Armour and a Weapon for Human Fungal Pathogens. vol. 425, Current Topics in Microbiology and Immunology, Springer , pp. 297-330. https://doi.org/10.1007/82_2019_182

Childers DS, Avelar GM, Bain JM, Larcombe DE, Pradhan A, Budge S et al. Impact of the Environment upon the Candida albicans Cell Wall and Resultant Effects upon Immune Surveillance. In Latge JP, editor, The Fungal Cell Wall: An Armour and a Weapon for Human Fungal Pathogens. Vol. 425. Springer . 2020. p. 297-330. (Current Topics in Microbiology and Immunology). Epub 2019 Nov 29. doi: 10.1007/82_2019_182

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Impact of the Environment upon the Candida albicans Cell Wall and Resultant Effects upon Immune Surveillance

Abstract

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