Impaired dynamic cerebral autoregulation in patients with cerebral amyloid angiopathy

Matthias Reinhard* (Corresponding Author), Leonie Lorenz, Linda Sommerlade, Arthur Allignol, Horst Urbach, Cornelius Weiller, Karl Egger

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Cerebral amyloid angiopathy (CAA) might disturb the sensitive mechanism of cerebral pressure autoregulation. This study examines whether dynamic cerebral autoregulation (CA) is impaired in the posterior or anterior circulation of CAA patients. Fifteen patients with known CAA on magnetic resonance imaging (MRI) and 14 age-matched controls were examined with transcranial Doppler. Dynamic CA was assessed in the middle (MCA) and posterior cerebral artery (PCA) via transfer function phase and gain during respiratory-induced 0.1 Hz oscillations of arterial pressure. Within the patient group, 4 patients showed additional microbleeds in the basal ganglia on the MRI performed within the study (pure CAA vs mixed microbleeds). PCA phase was significantly lower in patients compared with controls (p = 0.018), particularly in patients with pure CAA (p = 0.0034). MCA values showed a similar but non-significant trend towards lower phase in patients with pure CAA. Poorer phase was associated with a higher number of microbleeds on MRI (MCA r = −0.57, p = 0.027; PCA r = −0.52, p = 0.098) and superficial cortical siderosis (PCA: p = 0.0025). In conclusion, dynamic cerebral autoregulation is impaired in patients with CAA. The degree of impairment is associated with the extent of cerebral microbleeds.

Original languageEnglish
Pages (from-to)60-65
Number of pages6
JournalBrain Research
Volume1717
Early online date15 Apr 2019
DOIs
Publication statusPublished - 15 Aug 2019

Fingerprint

Cerebral Amyloid Angiopathy
Homeostasis
Posterior Cerebral Artery
Magnetic Resonance Imaging
Siderosis
Middle Cerebral Artery
Basal Ganglia
Arterial Pressure
Pressure

Keywords

  • Autoregulation
  • Cerebral amyloid angiopathy
  • Cerebral blood flow
  • Transcranial Doppler sonography

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Reinhard, M., Lorenz, L., Sommerlade, L., Allignol, A., Urbach, H., Weiller, C., & Egger, K. (2019). Impaired dynamic cerebral autoregulation in patients with cerebral amyloid angiopathy. Brain Research, 1717, 60-65. https://doi.org/10.1016/j.brainres.2019.04.014

Impaired dynamic cerebral autoregulation in patients with cerebral amyloid angiopathy. / Reinhard, Matthias (Corresponding Author); Lorenz, Leonie; Sommerlade, Linda; Allignol, Arthur; Urbach, Horst; Weiller, Cornelius; Egger, Karl.

In: Brain Research, Vol. 1717, 15.08.2019, p. 60-65.

Research output: Contribution to journalArticle

Reinhard, M, Lorenz, L, Sommerlade, L, Allignol, A, Urbach, H, Weiller, C & Egger, K 2019, 'Impaired dynamic cerebral autoregulation in patients with cerebral amyloid angiopathy', Brain Research, vol. 1717, pp. 60-65. https://doi.org/10.1016/j.brainres.2019.04.014
Reinhard M, Lorenz L, Sommerlade L, Allignol A, Urbach H, Weiller C et al. Impaired dynamic cerebral autoregulation in patients with cerebral amyloid angiopathy. Brain Research. 2019 Aug 15;1717:60-65. https://doi.org/10.1016/j.brainres.2019.04.014
Reinhard, Matthias ; Lorenz, Leonie ; Sommerlade, Linda ; Allignol, Arthur ; Urbach, Horst ; Weiller, Cornelius ; Egger, Karl. / Impaired dynamic cerebral autoregulation in patients with cerebral amyloid angiopathy. In: Brain Research. 2019 ; Vol. 1717. pp. 60-65.
@article{ad46a244da1a450fba06a180276ca59c,
title = "Impaired dynamic cerebral autoregulation in patients with cerebral amyloid angiopathy",
abstract = "Cerebral amyloid angiopathy (CAA) might disturb the sensitive mechanism of cerebral pressure autoregulation. This study examines whether dynamic cerebral autoregulation (CA) is impaired in the posterior or anterior circulation of CAA patients. Fifteen patients with known CAA on magnetic resonance imaging (MRI) and 14 age-matched controls were examined with transcranial Doppler. Dynamic CA was assessed in the middle (MCA) and posterior cerebral artery (PCA) via transfer function phase and gain during respiratory-induced 0.1 Hz oscillations of arterial pressure. Within the patient group, 4 patients showed additional microbleeds in the basal ganglia on the MRI performed within the study (pure CAA vs mixed microbleeds). PCA phase was significantly lower in patients compared with controls (p = 0.018), particularly in patients with pure CAA (p = 0.0034). MCA values showed a similar but non-significant trend towards lower phase in patients with pure CAA. Poorer phase was associated with a higher number of microbleeds on MRI (MCA r = −0.57, p = 0.027; PCA r = −0.52, p = 0.098) and superficial cortical siderosis (PCA: p = 0.0025). In conclusion, dynamic cerebral autoregulation is impaired in patients with CAA. The degree of impairment is associated with the extent of cerebral microbleeds.",
keywords = "Autoregulation, Cerebral amyloid angiopathy, Cerebral blood flow, Transcranial Doppler sonography",
author = "Matthias Reinhard and Leonie Lorenz and Linda Sommerlade and Arthur Allignol and Horst Urbach and Cornelius Weiller and Karl Egger",
year = "2019",
month = "8",
day = "15",
doi = "10.1016/j.brainres.2019.04.014",
language = "English",
volume = "1717",
pages = "60--65",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",

}

TY - JOUR

T1 - Impaired dynamic cerebral autoregulation in patients with cerebral amyloid angiopathy

AU - Reinhard, Matthias

AU - Lorenz, Leonie

AU - Sommerlade, Linda

AU - Allignol, Arthur

AU - Urbach, Horst

AU - Weiller, Cornelius

AU - Egger, Karl

PY - 2019/8/15

Y1 - 2019/8/15

N2 - Cerebral amyloid angiopathy (CAA) might disturb the sensitive mechanism of cerebral pressure autoregulation. This study examines whether dynamic cerebral autoregulation (CA) is impaired in the posterior or anterior circulation of CAA patients. Fifteen patients with known CAA on magnetic resonance imaging (MRI) and 14 age-matched controls were examined with transcranial Doppler. Dynamic CA was assessed in the middle (MCA) and posterior cerebral artery (PCA) via transfer function phase and gain during respiratory-induced 0.1 Hz oscillations of arterial pressure. Within the patient group, 4 patients showed additional microbleeds in the basal ganglia on the MRI performed within the study (pure CAA vs mixed microbleeds). PCA phase was significantly lower in patients compared with controls (p = 0.018), particularly in patients with pure CAA (p = 0.0034). MCA values showed a similar but non-significant trend towards lower phase in patients with pure CAA. Poorer phase was associated with a higher number of microbleeds on MRI (MCA r = −0.57, p = 0.027; PCA r = −0.52, p = 0.098) and superficial cortical siderosis (PCA: p = 0.0025). In conclusion, dynamic cerebral autoregulation is impaired in patients with CAA. The degree of impairment is associated with the extent of cerebral microbleeds.

AB - Cerebral amyloid angiopathy (CAA) might disturb the sensitive mechanism of cerebral pressure autoregulation. This study examines whether dynamic cerebral autoregulation (CA) is impaired in the posterior or anterior circulation of CAA patients. Fifteen patients with known CAA on magnetic resonance imaging (MRI) and 14 age-matched controls were examined with transcranial Doppler. Dynamic CA was assessed in the middle (MCA) and posterior cerebral artery (PCA) via transfer function phase and gain during respiratory-induced 0.1 Hz oscillations of arterial pressure. Within the patient group, 4 patients showed additional microbleeds in the basal ganglia on the MRI performed within the study (pure CAA vs mixed microbleeds). PCA phase was significantly lower in patients compared with controls (p = 0.018), particularly in patients with pure CAA (p = 0.0034). MCA values showed a similar but non-significant trend towards lower phase in patients with pure CAA. Poorer phase was associated with a higher number of microbleeds on MRI (MCA r = −0.57, p = 0.027; PCA r = −0.52, p = 0.098) and superficial cortical siderosis (PCA: p = 0.0025). In conclusion, dynamic cerebral autoregulation is impaired in patients with CAA. The degree of impairment is associated with the extent of cerebral microbleeds.

KW - Autoregulation

KW - Cerebral amyloid angiopathy

KW - Cerebral blood flow

KW - Transcranial Doppler sonography

UR - http://www.scopus.com/inward/record.url?scp=85064171218&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2019.04.014

DO - 10.1016/j.brainres.2019.04.014

M3 - Article

VL - 1717

SP - 60

EP - 65

JO - Brain Research

JF - Brain Research

SN - 0006-8993

ER -