Impairment of contextual fear conditioning in rats by Group I mGluRs: reversal by the nootropic nefiracetam

Gernot Riedel, K. Sandager-Nielsen, E. M. Macphail

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The blockade of Group I metabotropic glutamate receptors (mGluRs) may be a potential strategy for prevention therapy of neurotoxicity. We here confirm previous reports that systemic application of the Group I antagonist, 1-aminoindan-1,5-dicarboxylic acid (AIDA), causes amnesia in a contextual fear conditioning paradigm in rats. This deficit was fully reversed by long-term pretreatment with the nootropic nefiracetam, which in fact obtained supranormal performance. Our data suggest that application of Group I antagonists to prevent neurotoxicity, combined with nootropic treatment to prevent cognitive deficits, may be a therapeutic strategy for the development of novel antineurotoxic treatments. (C) 2002 Elsevier Science Inc. All rights reserved.

Original languageEnglish
Pages (from-to)391-399
Number of pages8
JournalPharmacology, Biochemistry & Behavior
Volume73
Issue number2
DOIs
Publication statusPublished - 2002

Keywords

  • metabotropic glutamate receptors (mGluRs)
  • nootropic
  • fear conditioning
  • memory
  • rat
  • METABOTROPIC GLUTAMATE RECEPTORS
  • LONG-TERM-POTENTIATION
  • COGNITION-ENHANCING AGENT
  • ANTAGONIST 1-AMINOINDAN-1,5-DICARBOXYLIC ACID
  • NICOTINIC ACETYLCHOLINE-RECEPTORS
  • WORKING-MEMORY
  • OLDER RABBITS
  • HIPPOCAMPAL NEUROTRANSMISSION
  • NEUROPROTECTIVE ACTIVITY
  • CORTICAL-NEURONS

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