Impairment of contextual fear conditioning in rats by Group I mGluRs: reversal by the nootropic nefiracetam

Gernot Riedel; K. Sandager-Nielsen; E. M. Macphail

doi:10.1016/S0091-3057(02)00830-4

Impairment of contextual fear conditioning in rats by Group I mGluRs: reversal by the nootropic nefiracetam

Gernot Riedel, K. Sandager-Nielsen, E. M. Macphail

Medical Sciences

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The blockade of Group I metabotropic glutamate receptors (mGluRs) may be a potential strategy for prevention therapy of neurotoxicity. We here confirm previous reports that systemic application of the Group I antagonist, 1-aminoindan-1,5-dicarboxylic acid (AIDA), causes amnesia in a contextual fear conditioning paradigm in rats. This deficit was fully reversed by long-term pretreatment with the nootropic nefiracetam, which in fact obtained supranormal performance. Our data suggest that application of Group I antagonists to prevent neurotoxicity, combined with nootropic treatment to prevent cognitive deficits, may be a therapeutic strategy for the development of novel antineurotoxic treatments. (C) 2002 Elsevier Science Inc. All rights reserved.

Original language	English
Pages (from-to)	391-399
Number of pages	8
Journal	Pharmacology, Biochemistry & Behavior
Volume	73
Issue number	2
DOIs	https://doi.org/10.1016/S0091-3057(02)00830-4
Publication status	Published - 2002

Keywords

metabotropic glutamate receptors (mGluRs)
nootropic
fear conditioning
memory
rat
METABOTROPIC GLUTAMATE RECEPTORS
LONG-TERM-POTENTIATION
COGNITION-ENHANCING AGENT
ANTAGONIST 1-AMINOINDAN-1,5-DICARBOXYLIC ACID
NICOTINIC ACETYLCHOLINE-RECEPTORS
WORKING-MEMORY
OLDER RABBITS
HIPPOCAMPAL NEUROTRANSMISSION
NEUROPROTECTIVE ACTIVITY
CORTICAL-NEURONS

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10.1016/S0091-3057(02)00830-4

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title = "Impairment of contextual fear conditioning in rats by Group I mGluRs: reversal by the nootropic nefiracetam",

abstract = "The blockade of Group I metabotropic glutamate receptors (mGluRs) may be a potential strategy for prevention therapy of neurotoxicity. We here confirm previous reports that systemic application of the Group I antagonist, 1-aminoindan-1,5-dicarboxylic acid (AIDA), causes amnesia in a contextual fear conditioning paradigm in rats. This deficit was fully reversed by long-term pretreatment with the nootropic nefiracetam, which in fact obtained supranormal performance. Our data suggest that application of Group I antagonists to prevent neurotoxicity, combined with nootropic treatment to prevent cognitive deficits, may be a therapeutic strategy for the development of novel antineurotoxic treatments. (C) 2002 Elsevier Science Inc. All rights reserved.",

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author = "Gernot Riedel and K. Sandager-Nielsen and Macphail, {E. M.}",

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doi = "10.1016/S0091-3057(02)00830-4",

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T1 - Impairment of contextual fear conditioning in rats by Group I mGluRs: reversal by the nootropic nefiracetam

AU - Riedel, Gernot

AU - Sandager-Nielsen, K.

AU - Macphail, E. M.

PY - 2002

Y1 - 2002

N2 - The blockade of Group I metabotropic glutamate receptors (mGluRs) may be a potential strategy for prevention therapy of neurotoxicity. We here confirm previous reports that systemic application of the Group I antagonist, 1-aminoindan-1,5-dicarboxylic acid (AIDA), causes amnesia in a contextual fear conditioning paradigm in rats. This deficit was fully reversed by long-term pretreatment with the nootropic nefiracetam, which in fact obtained supranormal performance. Our data suggest that application of Group I antagonists to prevent neurotoxicity, combined with nootropic treatment to prevent cognitive deficits, may be a therapeutic strategy for the development of novel antineurotoxic treatments. (C) 2002 Elsevier Science Inc. All rights reserved.

AB - The blockade of Group I metabotropic glutamate receptors (mGluRs) may be a potential strategy for prevention therapy of neurotoxicity. We here confirm previous reports that systemic application of the Group I antagonist, 1-aminoindan-1,5-dicarboxylic acid (AIDA), causes amnesia in a contextual fear conditioning paradigm in rats. This deficit was fully reversed by long-term pretreatment with the nootropic nefiracetam, which in fact obtained supranormal performance. Our data suggest that application of Group I antagonists to prevent neurotoxicity, combined with nootropic treatment to prevent cognitive deficits, may be a therapeutic strategy for the development of novel antineurotoxic treatments. (C) 2002 Elsevier Science Inc. All rights reserved.

KW - metabotropic glutamate receptors (mGluRs)

KW - nootropic

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KW - memory

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KW - ANTAGONIST 1-AMINOINDAN-1,5-DICARBOXYLIC ACID

KW - NICOTINIC ACETYLCHOLINE-RECEPTORS

KW - WORKING-MEMORY

KW - OLDER RABBITS

KW - HIPPOCAMPAL NEUROTRANSMISSION

KW - NEUROPROTECTIVE ACTIVITY

KW - CORTICAL-NEURONS

U2 - 10.1016/S0091-3057(02)00830-4

DO - 10.1016/S0091-3057(02)00830-4

M3 - Article

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VL - 73

SP - 391

EP - 399

JO - Pharmacology, Biochemistry & Behavior

JF - Pharmacology, Biochemistry & Behavior

IS - 2

ER -

Impairment of contextual fear conditioning in rats by Group I mGluRs: reversal by the nootropic nefiracetam

Abstract

Keywords

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