TY - JOUR
T1 - Impairment of Uterine Contractility Is Associated with Unexplained Infertility
AU - Hunt, Sarah
AU - Abdallah, Karim S.
AU - Ng, Ernest
AU - Rombauts, Luk
AU - Vollenhoven, Beverley
AU - Mol, Ben W.
N1 - Publisher Copyright:
© 2021 American Society of Civil Engineers (ASCE). All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/10/14
Y1 - 2020/10/14
N2 - The uterine junctional zone represents the juncture between endometrium and myometrium. The junctional zone is hormonally dependent and displays continuous peristaltic activity throughout the menstrual cycle in the nonpregnant state which is concerned with sperm transport and embryo implantation. Peristalsis may be observed using various invasive and noninvasive modalities, of which ultrasound is the most readily applied in the clinical setting. Women with pelvic pathology display alterations in uterine peristalsis which may contribute to infertility. Characterization of peristalsis in infertility subgroups, the development of a subjective peristalsis tool, and the application of potential therapeutics to an assisted reproductive treatment setting are the subject of ongoing investigation. Meta-Analysis indicates a potential role for oxytocin antagonist in the improvement of fertility treatments.
AB - The uterine junctional zone represents the juncture between endometrium and myometrium. The junctional zone is hormonally dependent and displays continuous peristaltic activity throughout the menstrual cycle in the nonpregnant state which is concerned with sperm transport and embryo implantation. Peristalsis may be observed using various invasive and noninvasive modalities, of which ultrasound is the most readily applied in the clinical setting. Women with pelvic pathology display alterations in uterine peristalsis which may contribute to infertility. Characterization of peristalsis in infertility subgroups, the development of a subjective peristalsis tool, and the application of potential therapeutics to an assisted reproductive treatment setting are the subject of ongoing investigation. Meta-Analysis indicates a potential role for oxytocin antagonist in the improvement of fertility treatments.
KW - endometrial contractions
KW - endometrial myometrial junction
KW - uterine junctional zone
KW - uterine peristalsis
UR - http://www.scopus.com/inward/record.url?scp=85093922650&partnerID=8YFLogxK
U2 - 10.1055/s-0040-1716409
DO - 10.1055/s-0040-1716409
M3 - Article
C2 - 33058089
AN - SCOPUS:85093922650
VL - 38
SP - 61
EP - 73
JO - Seminars in Reproductive Medicine
JF - Seminars in Reproductive Medicine
SN - 1526-8004
IS - 1
ER -