Importance of lipopolysaccharide and cyclic β-1,2-glucans in Brucella-mammalian infections

Andreas F Haag, Kamila K Myka, Markus F F Arnold, Paola Caro-Hernández, Gail Ferguson

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Brucella species are the causative agents of one of the most prevalent zoonotic diseases: brucellosis. Infections by Brucella species cause major economic losses in agriculture, leading to abortions in infected animals and resulting in a severe, although rarely lethal, debilitating disease in humans. Brucella species persist as intracellular pathogens that manage to effectively evade recognition by the host's immune system. Sugar-modified components in the Brucella cell envelope play an important role in their host interaction. Brucella lipopolysaccharide (LPS), unlike Escherichia coli LPS, does not trigger the host's innate immune system. Brucella produces cyclic ß-1,2-glucans, which are important for targeting them to their replicative niche in the endoplasmic reticulum within the host cell. This paper will focus on the role of LPS and cyclic ß-1,2-glucans in Brucella-mammalian infections and discuss the use of mutants, within the biosynthesis pathway of these cell envelope structures, in vaccine development.
Original languageEnglish
Article number124509
Number of pages12
JournalInternational Journal of Microbiology
Volume2010
DOIs
Publication statusPublished - 2010

Fingerprint Dive into the research topics of 'Importance of lipopolysaccharide and cyclic β-1,2-glucans in Brucella-mammalian infections'. Together they form a unique fingerprint.

  • Cite this