Improved synthesis of the hypoxia probe 5-deutero-5-fluoro-5-deoxy-azomycin arabinoside (FAZA) as a model process for tritium radiolabeling

Chiara Zanato, Andrea Testa, Matteo Zanda

Research output: Contribution to journalArticle

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Abstract

Tritium-labelled fluoroazomycin arabinoside, [3H]-FAZA, is a useful probe for the investigation of hypoxia, furthermore it is safer and easier to handle than the PET tracer [18F]-FAZA when used in cell based assays. The only known synthesis of deuterium- and tritium-labelled FAZA was re-investigated and optimized. Then, a new and improved synthesis of [2H]-FAZA was developed as a model process for tritium radiolabelling. This novel synthesis is expected to greatly facilitate access to [3H]-FAZA.
Original languageEnglish
Pages (from-to)110-117
Number of pages8
JournalJournal of Fluorine Chemistry
Volume155
Early online date29 Jun 2013
DOIs
Publication statusPublished - Nov 2013

Keywords

  • hypoxia
  • PET imaging
  • deuterium
  • tritium
  • FAZA

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