Improving adherence to medication in stroke survivors: a pilot randomised controlled trial

Ronan E. O'Carroll, Julie A. Chambers, Martin Dennis, Cathie Sudlow, Marie Johnston

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Background
Adherence to preventive medication is often poor, and current interventions have had limited success.
Purpose
This study was conducted to pilot a randomised controlled trial aimed at increasing adherence to preventive medication in stroke survivors using a brief, personalised intervention.
Methods
Sixty-two stroke survivors were randomly allocated to either a two-session intervention aimed at increasing adherence via (a) introducing a plan linked to environmental cues (implementation intentions) to help establish a better medication-taking routine (habit) and (b) eliciting and modifying any mistaken patient beliefs regarding medication/stroke or a control group. Primary outcome was adherence to antihypertensive medication measured objectively over 3 months using an electronic pill bottle.
Results
Fifty-eight people used the pill bottle and were analysed as allocated; 54 completed treatment. The intervention resulted in 10 % more doses taken on schedule (intervention, 97 %; control, 87 %; 95 % CI for difference (0.2, 16.2); p = 0.048).
Conclusions
A simple, brief intervention increased medication adherence in stroke survivors, over and above any effect of increased patient contact or mere measurement. (http://​controlled-trials.​com, number ISRCTN38274953.)
Original languageEnglish
Pages (from-to)358-368
Number of pages11
JournalAnnals of Behavioral Medicine
Volume46
Issue number3
Early online date14 May 2013
DOIs
Publication statusPublished - Dec 2013

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Medication Adherence
Survivors
Randomized Controlled Trials
Stroke
Antihypertensive Agents
Habits
Cues
Appointments and Schedules
Control Groups
Therapeutics

Keywords

  • stroke
  • adherence
  • medication beliefs
  • implementation intentions
  • antihypertensives

Cite this

Improving adherence to medication in stroke survivors : a pilot randomised controlled trial. / O'Carroll, Ronan E.; Chambers, Julie A.; Dennis, Martin; Sudlow, Cathie; Johnston, Marie.

In: Annals of Behavioral Medicine, Vol. 46, No. 3, 12.2013, p. 358-368.

Research output: Contribution to journalArticle

O'Carroll, Ronan E. ; Chambers, Julie A. ; Dennis, Martin ; Sudlow, Cathie ; Johnston, Marie. / Improving adherence to medication in stroke survivors : a pilot randomised controlled trial. In: Annals of Behavioral Medicine. 2013 ; Vol. 46, No. 3. pp. 358-368.
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N2 - BackgroundAdherence to preventive medication is often poor, and current interventions have had limited success.PurposeThis study was conducted to pilot a randomised controlled trial aimed at increasing adherence to preventive medication in stroke survivors using a brief, personalised intervention.MethodsSixty-two stroke survivors were randomly allocated to either a two-session intervention aimed at increasing adherence via (a) introducing a plan linked to environmental cues (implementation intentions) to help establish a better medication-taking routine (habit) and (b) eliciting and modifying any mistaken patient beliefs regarding medication/stroke or a control group. Primary outcome was adherence to antihypertensive medication measured objectively over 3 months using an electronic pill bottle.ResultsFifty-eight people used the pill bottle and were analysed as allocated; 54 completed treatment. The intervention resulted in 10 % more doses taken on schedule (intervention, 97 %; control, 87 %; 95 % CI for difference (0.2, 16.2); p = 0.048).ConclusionsA simple, brief intervention increased medication adherence in stroke survivors, over and above any effect of increased patient contact or mere measurement. (http://​controlled-trials.​com, number ISRCTN38274953.)

AB - BackgroundAdherence to preventive medication is often poor, and current interventions have had limited success.PurposeThis study was conducted to pilot a randomised controlled trial aimed at increasing adherence to preventive medication in stroke survivors using a brief, personalised intervention.MethodsSixty-two stroke survivors were randomly allocated to either a two-session intervention aimed at increasing adherence via (a) introducing a plan linked to environmental cues (implementation intentions) to help establish a better medication-taking routine (habit) and (b) eliciting and modifying any mistaken patient beliefs regarding medication/stroke or a control group. Primary outcome was adherence to antihypertensive medication measured objectively over 3 months using an electronic pill bottle.ResultsFifty-eight people used the pill bottle and were analysed as allocated; 54 completed treatment. The intervention resulted in 10 % more doses taken on schedule (intervention, 97 %; control, 87 %; 95 % CI for difference (0.2, 16.2); p = 0.048).ConclusionsA simple, brief intervention increased medication adherence in stroke survivors, over and above any effect of increased patient contact or mere measurement. (http://​controlled-trials.​com, number ISRCTN38274953.)

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