In utero exposure to cigarette smoke and NAFLD pathways: Sex and age specific effects in the human fetus

C. Talia* (Corresponding Author), P. Filis, U. Soffientini, B. Lucendo-Villarin, A. Douglas, D. Hay, S. Shaw, J. P. Iredale, M. J. Swortwood, M. A. Huestis, M. Bellingham, L. Connolly, P. J. O'Shaughnessy, P. A. Fowler

*Corresponding author for this work

Research output: Contribution to journalAbstractpeer-review

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is the major cause of chronic liver disease worldwide. In utero exposure to endocrine disruptors might cause obesogenic effects and the reprogramming of hepatic set points, influencing the initiation of the disease later in life. Maternal smoking, a unique model of real early-life exposure, is associated with increased risk of obesity and metabolic syndrome in offspring. We investigated effects of maternal smoking on human fetal liver pathways related to NAFLD pathogenesis.
Original languageEnglish
Pages (from-to)S63-S64
Number of pages2
JournalToxicology Letters
Volume295
Issue numberSupplement 1
Early online date12 Sep 2018
DOIs
Publication statusPublished - 10 Oct 2018
Event54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box - Brussels, Belgium
Duration: 2 Sep 20185 Sep 2018

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