The assessment of the longer-term in vivo response of a range of silicate-substituted hydroxyapatite (HA) ceramics using an ovine defect model was discussed. The phase pure HA, 0.8 wt. % silicate-substituted HA and 1.5 wt. % silicate-substituted HA were prepared by aqueous precipitation reactions. It was concluded that the bioactivity of HA granules was significantly enhanced by the substitution of 0.8 and 1.5 wt % silicate ions into the HA structure. The high-resolution transmission electron microscopy (HRTEM) studies demonstrated that the substitution of silicate ions increases the physiological dissolution rate of HA implants.
|Number of pages||11|
|Journal||Journal of Materials Science: Materials in Medicine|
|Publication status||Published - May 2005|
|Event||Transactions - 7th World Biomaterials Congress - Sydney, Australia|
Duration: 17 May 2004 → 21 May 2004
Patel, N., Brooks, R. A., Clarke, M. T., Lee, P. M., Rushton, N., Gibson, I. R., Best, S. M., & Bonfield, W. (2005). In vivo assessment of hydroxyapatite and silicate-substituted hydroxyapatite granules using an ovine defect model. Journal of Materials Science: Materials in Medicine, 16(5), 429-440.