In vivo assessment of hydroxyapatite and silicate-substituted hydroxyapatite granules using an ovine defect model

N. Patel, R. A. Brooks, M. T. Clarke, P. M. Lee, N. Rushton, Iain Ronald Gibson, S. M. Best, W. Bonfield

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Abstract

The assessment of the longer-term in vivo response of a range of silicate-substituted hydroxyapatite (HA) ceramics using an ovine defect model was discussed. The phase pure HA, 0.8 wt. % silicate-substituted HA and 1.5 wt. % silicate-substituted HA were prepared by aqueous precipitation reactions. It was concluded that the bioactivity of HA granules was significantly enhanced by the substitution of 0.8 and 1.5 wt % silicate ions into the HA structure. The high-resolution transmission electron microscopy (HRTEM) studies demonstrated that the substitution of silicate ions increases the physiological dissolution rate of HA implants.
Original languageEnglish
Pages (from-to)429-440
Number of pages11
JournalJournal of Materials Science: Materials in Medicine
Volume16
Issue number5
Publication statusPublished - May 2005
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: 17 May 200421 May 2004

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    Patel, N., Brooks, R. A., Clarke, M. T., Lee, P. M., Rushton, N., Gibson, I. R., Best, S. M., & Bonfield, W. (2005). In vivo assessment of hydroxyapatite and silicate-substituted hydroxyapatite granules using an ovine defect model. Journal of Materials Science: Materials in Medicine, 16(5), 429-440.