In vivo assessment of hydroxyapatite and silicate-substituted hydroxyapatite granules using an ovine defect model

N. Patel; R. A. Brooks; M. T. Clarke; P. M. Lee; N. Rushton; Iain Ronald Gibson; S. M. Best; W. Bonfield

In vivo assessment of hydroxyapatite and silicate-substituted hydroxyapatite granules using an ovine defect model

N. Patel, R. A. Brooks, M. T. Clarke, P. M. Lee, N. Rushton, Iain Ronald Gibson, S. M. Best, W. Bonfield

Research output: Contribution to journal › Article › peer-review

Abstract

The assessment of the longer-term in vivo response of a range of silicate-substituted hydroxyapatite (HA) ceramics using an ovine defect model was discussed. The phase pure HA, 0.8 wt. % silicate-substituted HA and 1.5 wt. % silicate-substituted HA were prepared by aqueous precipitation reactions. It was concluded that the bioactivity of HA granules was significantly enhanced by the substitution of 0.8 and 1.5 wt % silicate ions into the HA structure. The high-resolution transmission electron microscopy (HRTEM) studies demonstrated that the substitution of silicate ions increases the physiological dissolution rate of HA implants.

Original language	English
Pages (from-to)	429-440
Number of pages	11
Journal	Journal of Materials Science: Materials in Medicine
Volume	16
Issue number	5
Publication status	Published - May 2005
Event	Transactions - 7th World Biomaterials Congress - Sydney, Australia Duration: 17 May 2004 → 21 May 2004

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title = "In vivo assessment of hydroxyapatite and silicate-substituted hydroxyapatite granules using an ovine defect model",

abstract = "The assessment of the longer-term in vivo response of a range of silicate-substituted hydroxyapatite (HA) ceramics using an ovine defect model was discussed. The phase pure HA, 0.8 wt. % silicate-substituted HA and 1.5 wt. % silicate-substituted HA were prepared by aqueous precipitation reactions. It was concluded that the bioactivity of HA granules was significantly enhanced by the substitution of 0.8 and 1.5 wt % silicate ions into the HA structure. The high-resolution transmission electron microscopy (HRTEM) studies demonstrated that the substitution of silicate ions increases the physiological dissolution rate of HA implants.",

author = "N. Patel and Brooks, {R. A.} and Clarke, {M. T.} and Lee, {P. M.} and N. Rushton and Gibson, {Iain Ronald} and Best, {S. M.} and W. Bonfield",

year = "2005",

month = may,

language = "English",

volume = "16",

pages = "429--440",

journal = "Journal of Materials Science: Materials in Medicine",

issn = "0957-4530",

publisher = "Springer Netherlands",

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note = "Transactions - 7th World Biomaterials Congress ; Conference date: 17-05-2004 Through 21-05-2004",

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TY - JOUR

T1 - In vivo assessment of hydroxyapatite and silicate-substituted hydroxyapatite granules using an ovine defect model

AU - Patel, N.

AU - Brooks, R. A.

AU - Clarke, M. T.

AU - Lee, P. M.

AU - Rushton, N.

AU - Gibson, Iain Ronald

AU - Best, S. M.

AU - Bonfield, W.

PY - 2005/5

Y1 - 2005/5

N2 - The assessment of the longer-term in vivo response of a range of silicate-substituted hydroxyapatite (HA) ceramics using an ovine defect model was discussed. The phase pure HA, 0.8 wt. % silicate-substituted HA and 1.5 wt. % silicate-substituted HA were prepared by aqueous precipitation reactions. It was concluded that the bioactivity of HA granules was significantly enhanced by the substitution of 0.8 and 1.5 wt % silicate ions into the HA structure. The high-resolution transmission electron microscopy (HRTEM) studies demonstrated that the substitution of silicate ions increases the physiological dissolution rate of HA implants.

AB - The assessment of the longer-term in vivo response of a range of silicate-substituted hydroxyapatite (HA) ceramics using an ovine defect model was discussed. The phase pure HA, 0.8 wt. % silicate-substituted HA and 1.5 wt. % silicate-substituted HA were prepared by aqueous precipitation reactions. It was concluded that the bioactivity of HA granules was significantly enhanced by the substitution of 0.8 and 1.5 wt % silicate ions into the HA structure. The high-resolution transmission electron microscopy (HRTEM) studies demonstrated that the substitution of silicate ions increases the physiological dissolution rate of HA implants.

UR - http://www.scopus.com/inward/record.url?scp=13844278184&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 429

EP - 440

JO - Journal of Materials Science: Materials in Medicine

JF - Journal of Materials Science: Materials in Medicine

SN - 0957-4530

IS - 5

T2 - Transactions - 7th World Biomaterials Congress

Y2 - 17 May 2004 through 21 May 2004

ER -

In vivo assessment of hydroxyapatite and silicate-substituted hydroxyapatite granules using an ovine defect model

Abstract

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