In vivo field-cycling relaxometry using an insert coil for magnetic field offset

Kerrin J Pine, Fred Goldie, David J Lurie

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose
The T1 of tissue has a strong dependence on the measurement magnetic field strength. T1-dispersion could be a useful contrast parameter, but is unavailable to clinical MR systems which operate at fixed magnetic field strength. The purpose of this work was to implement a removable insert magnet coil for field-cycling T1-dispersion measurements on a vertical-field MRI scanner, by offsetting the static field over a volume of interest.

Methods
An insert magnet coil was constructed for use with a whole-body sized 59 milli-Tesla (mT) vertical-field, permanent-magnet based imager. The coil has diameter 38 cm and thickness 6.1 cm and a homogeneous region (± 5%) of 5 cm DSV, offset by 5 cm from the coil surface. Surface radiofrequency (RF) coils were also constructed.

Results
The insert coil was used in conjunction with a surface RF coil and a volume-localized inversion-recovery pulse sequence to plot T1-dispersion in a human volunteer's forearm over a range of field strengths from 1 mT to 70 mT.

Conclusion
T1-dispersion measurements were demonstrated on a fixed-field MRI scanner, using an insert coil. This demonstrates the feasibility of relaxation dispersion measurements on an otherwise conventional MR imager, facilitating the exploitation of T1-dispersion contrast for enhanced diagnosis. Magn Reson Med, 2013. © 2013 Wiley Periodicals, Inc.
Original languageEnglish
Pages (from-to)1492-1497
Number of pages6
JournalMagnetic Resonance in Medicine
Volume72
Issue number5
Early online date22 Nov 2013
DOIs
Publication statusPublished - Nov 2014

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Magnets
Magnetic Fields
Forearm
Volunteers

Keywords

  • field cycling
  • T1 relaxometry
  • nuclear magnetic resonance
  • insert coil

Cite this

In vivo field-cycling relaxometry using an insert coil for magnetic field offset. / Pine, Kerrin J; Goldie, Fred; Lurie, David J.

In: Magnetic Resonance in Medicine, Vol. 72, No. 5, 11.2014, p. 1492-1497.

Research output: Contribution to journalArticle

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abstract = "PurposeThe T1 of tissue has a strong dependence on the measurement magnetic field strength. T1-dispersion could be a useful contrast parameter, but is unavailable to clinical MR systems which operate at fixed magnetic field strength. The purpose of this work was to implement a removable insert magnet coil for field-cycling T1-dispersion measurements on a vertical-field MRI scanner, by offsetting the static field over a volume of interest.MethodsAn insert magnet coil was constructed for use with a whole-body sized 59 milli-Tesla (mT) vertical-field, permanent-magnet based imager. The coil has diameter 38 cm and thickness 6.1 cm and a homogeneous region (± 5{\%}) of 5 cm DSV, offset by 5 cm from the coil surface. Surface radiofrequency (RF) coils were also constructed.ResultsThe insert coil was used in conjunction with a surface RF coil and a volume-localized inversion-recovery pulse sequence to plot T1-dispersion in a human volunteer's forearm over a range of field strengths from 1 mT to 70 mT.ConclusionT1-dispersion measurements were demonstrated on a fixed-field MRI scanner, using an insert coil. This demonstrates the feasibility of relaxation dispersion measurements on an otherwise conventional MR imager, facilitating the exploitation of T1-dispersion contrast for enhanced diagnosis. Magn Reson Med, 2013. {\circledC} 2013 Wiley Periodicals, Inc.",
keywords = "field cycling, T1 relaxometry, nuclear magnetic resonance, insert coil",
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N2 - PurposeThe T1 of tissue has a strong dependence on the measurement magnetic field strength. T1-dispersion could be a useful contrast parameter, but is unavailable to clinical MR systems which operate at fixed magnetic field strength. The purpose of this work was to implement a removable insert magnet coil for field-cycling T1-dispersion measurements on a vertical-field MRI scanner, by offsetting the static field over a volume of interest.MethodsAn insert magnet coil was constructed for use with a whole-body sized 59 milli-Tesla (mT) vertical-field, permanent-magnet based imager. The coil has diameter 38 cm and thickness 6.1 cm and a homogeneous region (± 5%) of 5 cm DSV, offset by 5 cm from the coil surface. Surface radiofrequency (RF) coils were also constructed.ResultsThe insert coil was used in conjunction with a surface RF coil and a volume-localized inversion-recovery pulse sequence to plot T1-dispersion in a human volunteer's forearm over a range of field strengths from 1 mT to 70 mT.ConclusionT1-dispersion measurements were demonstrated on a fixed-field MRI scanner, using an insert coil. This demonstrates the feasibility of relaxation dispersion measurements on an otherwise conventional MR imager, facilitating the exploitation of T1-dispersion contrast for enhanced diagnosis. Magn Reson Med, 2013. © 2013 Wiley Periodicals, Inc.

AB - PurposeThe T1 of tissue has a strong dependence on the measurement magnetic field strength. T1-dispersion could be a useful contrast parameter, but is unavailable to clinical MR systems which operate at fixed magnetic field strength. The purpose of this work was to implement a removable insert magnet coil for field-cycling T1-dispersion measurements on a vertical-field MRI scanner, by offsetting the static field over a volume of interest.MethodsAn insert magnet coil was constructed for use with a whole-body sized 59 milli-Tesla (mT) vertical-field, permanent-magnet based imager. The coil has diameter 38 cm and thickness 6.1 cm and a homogeneous region (± 5%) of 5 cm DSV, offset by 5 cm from the coil surface. Surface radiofrequency (RF) coils were also constructed.ResultsThe insert coil was used in conjunction with a surface RF coil and a volume-localized inversion-recovery pulse sequence to plot T1-dispersion in a human volunteer's forearm over a range of field strengths from 1 mT to 70 mT.ConclusionT1-dispersion measurements were demonstrated on a fixed-field MRI scanner, using an insert coil. This demonstrates the feasibility of relaxation dispersion measurements on an otherwise conventional MR imager, facilitating the exploitation of T1-dispersion contrast for enhanced diagnosis. Magn Reson Med, 2013. © 2013 Wiley Periodicals, Inc.

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