In-vivo magnetic resonance imaging studies of mammogenesis in non-pregnant goats treated with exogenous steroids

Paul Alfred Francois Fowler, Christopher Knight, Margaret A Foster

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Mammogenesis and lactation were induced in five multiparous, non-pregnant goats by treatment with oestrogen and progesterone for 11 d, followed by dexamethasone for 3 d. Reserpine was administered during the last 5 d. All five goats lactated, although milk yield was less than had been achieved in previous natural lactations. Mammary development was assessed in vivo, using magnetic resonance imaging. Although parenchyma volume increased by more than 6-fold overall, only 25 % of this increase occurred during steroid treatment. Most development took place after the cessation of treatment, when milking commenced. Maximum size was not achieved until week 8 of the induced lactation, and was only 70 % of normal parenchyma volume. After 18 weeks lactation the activities of three key milk synthetic enzymes were very similar to values previously found in natural lactations, and secretion efficiency (milk production per unit volume of parenchyma) was also similar to that of natural lactations. We conclude that the lower than normal milk yields were associated with incomplete proliferation of mammary tissue, rather than inadequate differentiation of individual secretory cells.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalJournal of Dairy Research
Volume58
Issue number2
DOIs
Publication statusPublished - May 1991

Keywords

  • mammary development
  • induced lactation
  • hormone
  • progesterone
  • induction
  • prolactin
  • tissue

Cite this

In-vivo magnetic resonance imaging studies of mammogenesis in non-pregnant goats treated with exogenous steroids. / Fowler, Paul Alfred Francois; Knight, Christopher; Foster, Margaret A.

In: Journal of Dairy Research, Vol. 58, No. 2, 05.1991, p. 151-157.

Research output: Contribution to journalArticle

@article{053639d895414142a86e13ddc5a22f93,
title = "In-vivo magnetic resonance imaging studies of mammogenesis in non-pregnant goats treated with exogenous steroids",
abstract = "Mammogenesis and lactation were induced in five multiparous, non-pregnant goats by treatment with oestrogen and progesterone for 11 d, followed by dexamethasone for 3 d. Reserpine was administered during the last 5 d. All five goats lactated, although milk yield was less than had been achieved in previous natural lactations. Mammary development was assessed in vivo, using magnetic resonance imaging. Although parenchyma volume increased by more than 6-fold overall, only 25 {\%} of this increase occurred during steroid treatment. Most development took place after the cessation of treatment, when milking commenced. Maximum size was not achieved until week 8 of the induced lactation, and was only 70 {\%} of normal parenchyma volume. After 18 weeks lactation the activities of three key milk synthetic enzymes were very similar to values previously found in natural lactations, and secretion efficiency (milk production per unit volume of parenchyma) was also similar to that of natural lactations. We conclude that the lower than normal milk yields were associated with incomplete proliferation of mammary tissue, rather than inadequate differentiation of individual secretory cells.",
keywords = "mammary development, induced lactation, hormone, progesterone, induction, prolactin, tissue",
author = "Fowler, {Paul Alfred Francois} and Christopher Knight and Foster, {Margaret A}",
year = "1991",
month = "5",
doi = "10.1017/S0022029900029691",
language = "English",
volume = "58",
pages = "151--157",
journal = "Journal of Dairy Research",
issn = "0022-0299",
publisher = "Cambridge University Press",
number = "2",

}

TY - JOUR

T1 - In-vivo magnetic resonance imaging studies of mammogenesis in non-pregnant goats treated with exogenous steroids

AU - Fowler, Paul Alfred Francois

AU - Knight, Christopher

AU - Foster, Margaret A

PY - 1991/5

Y1 - 1991/5

N2 - Mammogenesis and lactation were induced in five multiparous, non-pregnant goats by treatment with oestrogen and progesterone for 11 d, followed by dexamethasone for 3 d. Reserpine was administered during the last 5 d. All five goats lactated, although milk yield was less than had been achieved in previous natural lactations. Mammary development was assessed in vivo, using magnetic resonance imaging. Although parenchyma volume increased by more than 6-fold overall, only 25 % of this increase occurred during steroid treatment. Most development took place after the cessation of treatment, when milking commenced. Maximum size was not achieved until week 8 of the induced lactation, and was only 70 % of normal parenchyma volume. After 18 weeks lactation the activities of three key milk synthetic enzymes were very similar to values previously found in natural lactations, and secretion efficiency (milk production per unit volume of parenchyma) was also similar to that of natural lactations. We conclude that the lower than normal milk yields were associated with incomplete proliferation of mammary tissue, rather than inadequate differentiation of individual secretory cells.

AB - Mammogenesis and lactation were induced in five multiparous, non-pregnant goats by treatment with oestrogen and progesterone for 11 d, followed by dexamethasone for 3 d. Reserpine was administered during the last 5 d. All five goats lactated, although milk yield was less than had been achieved in previous natural lactations. Mammary development was assessed in vivo, using magnetic resonance imaging. Although parenchyma volume increased by more than 6-fold overall, only 25 % of this increase occurred during steroid treatment. Most development took place after the cessation of treatment, when milking commenced. Maximum size was not achieved until week 8 of the induced lactation, and was only 70 % of normal parenchyma volume. After 18 weeks lactation the activities of three key milk synthetic enzymes were very similar to values previously found in natural lactations, and secretion efficiency (milk production per unit volume of parenchyma) was also similar to that of natural lactations. We conclude that the lower than normal milk yields were associated with incomplete proliferation of mammary tissue, rather than inadequate differentiation of individual secretory cells.

KW - mammary development

KW - induced lactation

KW - hormone

KW - progesterone

KW - induction

KW - prolactin

KW - tissue

U2 - 10.1017/S0022029900029691

DO - 10.1017/S0022029900029691

M3 - Article

VL - 58

SP - 151

EP - 157

JO - Journal of Dairy Research

JF - Journal of Dairy Research

SN - 0022-0299

IS - 2

ER -