Inactivation of anandamide signaling

A continuing Debate

H. Khairy, Wael E Houssen

Research output: Contribution to journalArticle

3 Citations (Scopus)
3 Downloads (Pure)

Abstract

Since the first endocannabinoid anandamide was identified in 1992, extensive research has been conducted to characterize the elements of the tightly controlled endocannabinoid signaling system. While it was established that the activity of endocannabinoids are terminated by a two-step process that includes cellular uptake and degradation, there is still a continuing debate about the mechanistic role of these rocesses in inactivating anandamide signals.
Original languageEnglish
Pages (from-to)3355-3370
Number of pages16
JournalPharmaceuticals
Volume3
Issue number11
DOIs
Publication statusPublished - 1 Jan 2010

Fingerprint

Endocannabinoids
Research
anandamide

Keywords

  • endocannabinoid inactivation
  • anandamide
  • ethanolamine

Cite this

Inactivation of anandamide signaling : A continuing Debate. / Khairy, H.; Houssen, Wael E.

In: Pharmaceuticals, Vol. 3, No. 11, 01.01.2010, p. 3355-3370.

Research output: Contribution to journalArticle

@article{eb16ab7e962a4121a0ca220cf2df612f,
title = "Inactivation of anandamide signaling: A continuing Debate",
abstract = "Since the first endocannabinoid anandamide was identified in 1992, extensive research has been conducted to characterize the elements of the tightly controlled endocannabinoid signaling system. While it was established that the activity of endocannabinoids are terminated by a two-step process that includes cellular uptake and degradation, there is still a continuing debate about the mechanistic role of these rocesses in inactivating anandamide signals.",
keywords = "endocannabinoid inactivation, anandamide, ethanolamine",
author = "H. Khairy and Houssen, {Wael E}",
note = "Copyright 2011 Elsevier B.V., All rights reserved.",
year = "2010",
month = "1",
day = "1",
doi = "10.3390/ph3113355",
language = "English",
volume = "3",
pages = "3355--3370",
journal = "Pharmaceuticals",
issn = "1424-8247",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "11",

}

TY - JOUR

T1 - Inactivation of anandamide signaling

T2 - A continuing Debate

AU - Khairy, H.

AU - Houssen, Wael E

N1 - Copyright 2011 Elsevier B.V., All rights reserved.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Since the first endocannabinoid anandamide was identified in 1992, extensive research has been conducted to characterize the elements of the tightly controlled endocannabinoid signaling system. While it was established that the activity of endocannabinoids are terminated by a two-step process that includes cellular uptake and degradation, there is still a continuing debate about the mechanistic role of these rocesses in inactivating anandamide signals.

AB - Since the first endocannabinoid anandamide was identified in 1992, extensive research has been conducted to characterize the elements of the tightly controlled endocannabinoid signaling system. While it was established that the activity of endocannabinoids are terminated by a two-step process that includes cellular uptake and degradation, there is still a continuing debate about the mechanistic role of these rocesses in inactivating anandamide signals.

KW - endocannabinoid inactivation

KW - anandamide

KW - ethanolamine

UR - http://www.scopus.com/inward/record.url?scp=78650319514&partnerID=8YFLogxK

U2 - 10.3390/ph3113355

DO - 10.3390/ph3113355

M3 - Article

VL - 3

SP - 3355

EP - 3370

JO - Pharmaceuticals

JF - Pharmaceuticals

SN - 1424-8247

IS - 11

ER -