Inadequate office endometrial sample requires further evaluation in women with postmenopausal bleeding and abnormal ultrasound results

H. C. van Doorn*, B. C. Opmeer, C. W. Burger, M. J. Duk, G. S. Kooi, B. W.J. Mol

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Objective: To determine whether further histologic assessment can be omitted after office sampling produced a nondiagnostic specimen. Methods: Data were retrieved from a prospective cohort study of 913 women presenting with postmenopausal bleeding. This study was limited to women with an endometrial thickness either 5 mm or greater or that could not be measured, and in whom an endometrial biopsy performed in the office yielded nondiagnostic results. Results: Endometrial thickness was nonreassuring or unknown in 516 women, of whom 403 (78.1%) underwent office endometrial sampling. In 66 women the amount of tissue obtained was not sufficient for pathologic characterization. Further investigation revealed an endometrial malignancy in 3 of these 66 women and atypical hyperplasia in 1. Conclusion: In women with postmenopausal bleeding and a nonreassuring transvaginal ultrasound evaluation, a nondiagnostic office endometrial sample does not rule out endometrial cancer and further endometrial sampling is advisable.

Original languageEnglish
Pages (from-to)100-104
Number of pages5
JournalInternational Journal of Gynecology and Obstetrics
Volume99
Issue number2
DOIs
Publication statusPublished - Nov 2007

Keywords

  • Endometrial cancer
  • Endometrial thickness
  • Nondiagnostic sample
  • Office endometrial sampling
  • Transvaginal sonography

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