TY - JOUR
T1 - Inbred lines of mice derived from long-term growth selected lines: unique resources for mapping growth genes.
AU - Bünger, L
AU - Laidlaw, A
AU - Bulfield, G
AU - Eisen, EJ
AU - Medrano, JF
AU - Bradford, GE
AU - Pirchner, F
AU - Renne, U
AU - Schlote, W
AU - Hill, WG
PY - 2001/9
Y1 - 2001/9
N2 - Lines of mice selected for many generations for high or low growth in several laboratories around the world have been collected, and from these, inbred lines are being developed by recurrent full-sib mating in Edinburgh. There are seven high selected lines and four low lines (each low line is from the same base population as one of the high lines), and the histories of each are summarized. Mean body weight of males at 70 days of age in the Edinburgh laboratory in the heaviest inbred line (77 g) is 4.8-fold higher than in the lightest line (16 g), and 1.9-fold higher than in the least extreme high line (41 g). Litter size, food intake, and fat content also differ substantially. These inbred extreme selected lines are a uniquely valuable resource for QTL or gene mapping, candidate gene identification, and elucidation of epistatic effects.
AB - Lines of mice selected for many generations for high or low growth in several laboratories around the world have been collected, and from these, inbred lines are being developed by recurrent full-sib mating in Edinburgh. There are seven high selected lines and four low lines (each low line is from the same base population as one of the high lines), and the histories of each are summarized. Mean body weight of males at 70 days of age in the Edinburgh laboratory in the heaviest inbred line (77 g) is 4.8-fold higher than in the lightest line (16 g), and 1.9-fold higher than in the least extreme high line (41 g). Litter size, food intake, and fat content also differ substantially. These inbred extreme selected lines are a uniquely valuable resource for QTL or gene mapping, candidate gene identification, and elucidation of epistatic effects.
UR - http://europepmc.org/abstract/med/11641715
U2 - 10.1007/s00335-001-3018-6
DO - 10.1007/s00335-001-3018-6
M3 - Article
C2 - 11641715
VL - 12
SP - 678
EP - 686
JO - Mammalian genome : official journal of the International Mammalian Genome Society
JF - Mammalian genome : official journal of the International Mammalian Genome Society
ER -