Inbreeding coefficient and heterozygosity-fitness correlations in unhatched and hatched song sparrow nestmates

Sabrina S. Taylor, Rebecca J. Sardell, Jane M. Reid, Thomas Bucher, Nathan G. Taylor, Peter Arcese, Lukas F. Keller

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Heterozygosity-fitness correlations use molecular measures of heterozygosity as proxy estimates of individual inbreeding coefficients (f) to examine relationships between inbreeding and fitness traits. Heterozygosity-fitness correlations partly depend on the assumption that individual heterozygosity and f are strongly and negatively correlated. Although theory predicts that this relationship will be strongest when mean f and variance in f are high, few studies of heterozygosity-fitness correlations include estimates of f based on pedigrees, which allow for more thorough examinations of the relationship between f, heterozygosity and fitness in nature. We examined relationships between pedigree-based estimates of f, multilocus heterozygosity (MLH) and the probability of survival to hatch in song sparrow nestmates. f and MLH were weakly, but significantly negatively correlated. Inbreeding coefficient predicted the probability of survival to hatch. In contrast, MLH did not predict the probability of survival to hatch nor did it account for residual variation in survival to hatch after statistically controlling for the effects of f. These results are consistent with the expectation that heterozygosity-f correlations will be weak when mean and variance in f are low. Our results also provide empirical support for recent simulation studies, which show that variation in MLH among siblings with equal f can be large and may obscure MLH-fitness relationships.

Original languageEnglish
Pages (from-to)4454-4461
Number of pages8
JournalMolecular Ecology
Volume19
Issue number20
Early online date20 Sep 2010
DOIs
Publication statusPublished - Oct 2010

Keywords

  • Heterozygosity-fitness correlations
  • inbreeding
  • inbreeding depression
  • Melospiza melodia
  • pedigree
  • song sparrow
  • microsatellite loci
  • multilocus heterozygosity
  • population bottleneck
  • island population
  • Soay sheep
  • great tit
  • depression
  • wild
  • immigration

Cite this

Inbreeding coefficient and heterozygosity-fitness correlations in unhatched and hatched song sparrow nestmates. / Taylor, Sabrina S.; Sardell, Rebecca J.; Reid, Jane M.; Bucher, Thomas; Taylor, Nathan G.; Arcese, Peter; Keller, Lukas F.

In: Molecular Ecology, Vol. 19, No. 20, 10.2010, p. 4454-4461.

Research output: Contribution to journalArticle

Taylor, Sabrina S. ; Sardell, Rebecca J. ; Reid, Jane M. ; Bucher, Thomas ; Taylor, Nathan G. ; Arcese, Peter ; Keller, Lukas F. / Inbreeding coefficient and heterozygosity-fitness correlations in unhatched and hatched song sparrow nestmates. In: Molecular Ecology. 2010 ; Vol. 19, No. 20. pp. 4454-4461.
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