Incidence of cancer among UK Gulf war veterans:cohort study

Gary John MacFarlane, A. M. Biggs, N. Maconochie, M. Hotopf, P. Doyle, M. Lunt

Research output: Contribution to journalEditorial

44 Citations (Scopus)

Abstract

Objectives To determine whether incidence rates of cancer are higher in UK service personnel who were deployed in the Gulf war than in those not deployed and whether any increased risk of cancer is related to self reported exposures to potentially hazardous material during the period of deployment.

Design A cohort study with follow up from 1 April 1991 (the end of the Gulf war) to 31 July 2002. Participants 51721 Gulf war veterans and 50 755 service personnel matched for age, sex, rank, service, and level of fitness who were not deployed in the Gulf (the Era cohort).

Main outcome measures Incident cancers, identified on the NHS central register.

Results There were 270 incident cancers among the Gulf cohort and 269 among the Era cohort (incidence rate ratio 0.99, 95% confidence interval 0.83 to 1.17). There was no excess in site specific cancers among the Gulf cohort. Adjustment for lifestyle factors (smoking and alcohol consumption) did not alter these results. In the Gulf cohort, risk of cancer was not related to multiple vaccinations or exposure to pesticides or depleted uranium during deployment.

Conclusion There is no current excess risk of cancer overall nor of site specific cancers in Gulf war veterans. Specific exposures during deployment have not resulted in a subsequent increased risk of cancer. The long latent period for cancer, however, necessitates the continued follow up of these cohorts.

Original languageEnglish
Pages (from-to)1373-1375
Number of pages5
JournalJournal of Epidemiology and Community Health
Volume327
Publication statusPublished - Dec 2003

Keywords

  • HEALTH
  • MORTALITY

Cite this

MacFarlane, G. J., Biggs, A. M., Maconochie, N., Hotopf, M., Doyle, P., & Lunt, M. (2003). Incidence of cancer among UK Gulf war veterans:cohort study. Journal of Epidemiology and Community Health, 327, 1373-1375.

Incidence of cancer among UK Gulf war veterans:cohort study. / MacFarlane, Gary John; Biggs, A. M.; Maconochie, N.; Hotopf, M.; Doyle, P.; Lunt, M.

In: Journal of Epidemiology and Community Health, Vol. 327, 12.2003, p. 1373-1375.

Research output: Contribution to journalEditorial

MacFarlane, GJ, Biggs, AM, Maconochie, N, Hotopf, M, Doyle, P & Lunt, M 2003, 'Incidence of cancer among UK Gulf war veterans:cohort study', Journal of Epidemiology and Community Health, vol. 327, pp. 1373-1375.
MacFarlane GJ, Biggs AM, Maconochie N, Hotopf M, Doyle P, Lunt M. Incidence of cancer among UK Gulf war veterans:cohort study. Journal of Epidemiology and Community Health. 2003 Dec;327:1373-1375.
MacFarlane, Gary John ; Biggs, A. M. ; Maconochie, N. ; Hotopf, M. ; Doyle, P. ; Lunt, M. / Incidence of cancer among UK Gulf war veterans:cohort study. In: Journal of Epidemiology and Community Health. 2003 ; Vol. 327. pp. 1373-1375.
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abstract = "Objectives To determine whether incidence rates of cancer are higher in UK service personnel who were deployed in the Gulf war than in those not deployed and whether any increased risk of cancer is related to self reported exposures to potentially hazardous material during the period of deployment.Design A cohort study with follow up from 1 April 1991 (the end of the Gulf war) to 31 July 2002. Participants 51721 Gulf war veterans and 50 755 service personnel matched for age, sex, rank, service, and level of fitness who were not deployed in the Gulf (the Era cohort).Main outcome measures Incident cancers, identified on the NHS central register.Results There were 270 incident cancers among the Gulf cohort and 269 among the Era cohort (incidence rate ratio 0.99, 95{\%} confidence interval 0.83 to 1.17). There was no excess in site specific cancers among the Gulf cohort. Adjustment for lifestyle factors (smoking and alcohol consumption) did not alter these results. In the Gulf cohort, risk of cancer was not related to multiple vaccinations or exposure to pesticides or depleted uranium during deployment.Conclusion There is no current excess risk of cancer overall nor of site specific cancers in Gulf war veterans. Specific exposures during deployment have not resulted in a subsequent increased risk of cancer. The long latent period for cancer, however, necessitates the continued follow up of these cohorts.",
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T1 - Incidence of cancer among UK Gulf war veterans:cohort study

AU - MacFarlane, Gary John

AU - Biggs, A. M.

AU - Maconochie, N.

AU - Hotopf, M.

AU - Doyle, P.

AU - Lunt, M.

PY - 2003/12

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N2 - Objectives To determine whether incidence rates of cancer are higher in UK service personnel who were deployed in the Gulf war than in those not deployed and whether any increased risk of cancer is related to self reported exposures to potentially hazardous material during the period of deployment.Design A cohort study with follow up from 1 April 1991 (the end of the Gulf war) to 31 July 2002. Participants 51721 Gulf war veterans and 50 755 service personnel matched for age, sex, rank, service, and level of fitness who were not deployed in the Gulf (the Era cohort).Main outcome measures Incident cancers, identified on the NHS central register.Results There were 270 incident cancers among the Gulf cohort and 269 among the Era cohort (incidence rate ratio 0.99, 95% confidence interval 0.83 to 1.17). There was no excess in site specific cancers among the Gulf cohort. Adjustment for lifestyle factors (smoking and alcohol consumption) did not alter these results. In the Gulf cohort, risk of cancer was not related to multiple vaccinations or exposure to pesticides or depleted uranium during deployment.Conclusion There is no current excess risk of cancer overall nor of site specific cancers in Gulf war veterans. Specific exposures during deployment have not resulted in a subsequent increased risk of cancer. The long latent period for cancer, however, necessitates the continued follow up of these cohorts.

AB - Objectives To determine whether incidence rates of cancer are higher in UK service personnel who were deployed in the Gulf war than in those not deployed and whether any increased risk of cancer is related to self reported exposures to potentially hazardous material during the period of deployment.Design A cohort study with follow up from 1 April 1991 (the end of the Gulf war) to 31 July 2002. Participants 51721 Gulf war veterans and 50 755 service personnel matched for age, sex, rank, service, and level of fitness who were not deployed in the Gulf (the Era cohort).Main outcome measures Incident cancers, identified on the NHS central register.Results There were 270 incident cancers among the Gulf cohort and 269 among the Era cohort (incidence rate ratio 0.99, 95% confidence interval 0.83 to 1.17). There was no excess in site specific cancers among the Gulf cohort. Adjustment for lifestyle factors (smoking and alcohol consumption) did not alter these results. In the Gulf cohort, risk of cancer was not related to multiple vaccinations or exposure to pesticides or depleted uranium during deployment.Conclusion There is no current excess risk of cancer overall nor of site specific cancers in Gulf war veterans. Specific exposures during deployment have not resulted in a subsequent increased risk of cancer. The long latent period for cancer, however, necessitates the continued follow up of these cohorts.

KW - HEALTH

KW - MORTALITY

M3 - Editorial

VL - 327

SP - 1373

EP - 1375

JO - Journal of Epidemiology and Community Health

JF - Journal of Epidemiology and Community Health

SN - 0143-005X

ER -