Incident ischaemic stroke and Type 2 diabetes: trends in incidence and case fatality in Scotland 2004-2013

Scottish Diabetes Research Network (SDRN) Epidemiology group

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

AIM: To describe trends in first ischaemic stroke incidence and case fatality in adults with and without a diagnosis of Type 2 diabetes prior to their ischaemic stroke event in Scotland between 2004 and 2013.

METHODS: Using population-wide hospital admission, death and diabetes datasets, we conducted a retrospective cohort study. Negative binomial and logistic regression models were used to calculate year-specific incidence and case-fatality rates for people with Type 2 diabetes and for people without diabetes.

RESULTS: During 41.0 million person-years of follow-up there were 69 757 ischaemic stroke events. Type 2 diabetes prevalence among patients who experienced ischaemic stroke increased from 13.5% to 20.3% between 2004 and 2013. Stroke incidence rates declined by 2.7% (95% CI 2.4, 3.0) annually for people with and without diabetes [diabetes/year interaction: rate ratio 0.99 (95% CI 0.98, 1.01)]. Type 2 diabetes was associated with an increased risk of ischaemic stroke in men [rate ratio 1.23 (95% CI 1.17, 1.30)] and women [rate ratio 1.41 (95% CI 1.35, 1.48)]. Case-fatality rates were 14.2% and 12.7% in people with Type 2 diabetes and without diabetes, respectively. Case fatality declined by 3.5% (95% CI 2.7, 4.5) annually [diabetes/year interaction: odds ratio 1.01 (95% CI 0.98, 1.02)].

CONCLUSIONS: Ischaemic stroke incidence declined no faster in people with a diagnosis of Type 2 diabetes than in people without diabetes. Increasing prevalence of Type 2 diabetes among stroke patients may mean that declines in case fatality over time will be less marked in the future.

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalDiabetic Medicine
Volume35
Issue number1
Early online date6 Nov 2017
DOIs
Publication statusPublished - Jan 2018

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Brain Ischemia/complications
  • Cohort Studies
  • Diabetes Mellitus, Type 2/epidemiology
  • Female
  • Humans
  • Incidence
  • Logistic Models
  • Male
  • Middle Aged
  • Mortality
  • Retrospective Studies
  • Scotland/epidemiology
  • Stroke/epidemiology
  • Young Adult

Fingerprint

Dive into the research topics of 'Incident ischaemic stroke and Type 2 diabetes: trends in incidence and case fatality in Scotland 2004-2013'. Together they form a unique fingerprint.

Cite this