Increased Body Mass Index is Associated with Sarcopenia and Related Outcomes

Nurul Nabilah Akmal Hashim, Sumaiyah Mat, Phyo Kyaw Myint, Sheng Hui Kioh, Mirela Delibegovic, Ai-Vyrn Chin, Shahrul Bahyah Kamaruzzaman, Noran Naqiah Hair, Selina Khoo, Tan Maw Pin* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review


Sarcopenia, characterized by loss of lean body mass, muscle strength and physical performance in older adults, is a geriatric syndrome. Physical inactivity, increasing sedentary behaviour, as well as poor nutritional and health status enhance the progressive decline of muscle function and strength among older adults. Previous studies have highlighted being underweight as an important risk factor for sarcopenia which may be compounded by progressive loss of body mass and muscle strength during ageing. However, total body fat is known to increase with age. Sarcopenia and excessive adiposity may, therefore, share similar pathophysiology since both involve low-grade inflammation with accelerated muscle catabolism.
Original languageEnglish
Article numbere13874
Number of pages8
JournalEuropean Journal of Clinical Investigation
Issue number2
Early online date25 Sep 2022
Publication statusPublished - 1 Feb 2023


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