Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients

G. Almer; Peter Teismann; Z. Stevic; J. Halaschek-Wiener; L. Deecke; V. Kostic; S. Przedborski

Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients

G. Almer, Peter Teismann, Z. Stevic, J. Halaschek-Wiener, L. Deecke, V. Kostic, S. Przedborski

Medical Sciences

Research output: Contribution to journal › Article › peer-review

119 Citations (Scopus)

Abstract

Levels of the potent pro-inflammatory prostaglandin E-2 (PGE(2)) are elevated in postmortem spinal cords from patients with ALS, and inhibition of a key PGE(2)-synthesizing enzyme, cylcooxygenase-2, is neuroprotective in an in vitro model of ALS. The authors report that 82% of the patients with ALS studied had 2 to 10 times higher PGE(2) levels in CSF compared with normal control subjects. That affected areas of the CNS are inflamed in ALS supports this. CSF PGE(2) measurement may be useful in monitoring treatment for ALS.

Original language	English
Pages (from-to)	1277-1279
Number of pages	3
Journal	Neurology
Volume	58
Publication status	Published - 2002

Keywords

amyotrophic-lateral-sclerosis
Parkinsons-disease
cyclooxygenase-2
model

Cite this

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title = "Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients",

abstract = "Levels of the potent pro-inflammatory prostaglandin E-2 (PGE(2)) are elevated in postmortem spinal cords from patients with ALS, and inhibition of a key PGE(2)-synthesizing enzyme, cylcooxygenase-2, is neuroprotective in an in vitro model of ALS. The authors report that 82% of the patients with ALS studied had 2 to 10 times higher PGE(2) levels in CSF compared with normal control subjects. That affected areas of the CNS are inflamed in ALS supports this. CSF PGE(2) measurement may be useful in monitoring treatment for ALS.",

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T1 - Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients

AU - Almer, G.

AU - Teismann, Peter

AU - Stevic, Z.

AU - Halaschek-Wiener, J.

AU - Deecke, L.

AU - Kostic, V.

AU - Przedborski, S.

PY - 2002

Y1 - 2002

N2 - Levels of the potent pro-inflammatory prostaglandin E-2 (PGE(2)) are elevated in postmortem spinal cords from patients with ALS, and inhibition of a key PGE(2)-synthesizing enzyme, cylcooxygenase-2, is neuroprotective in an in vitro model of ALS. The authors report that 82% of the patients with ALS studied had 2 to 10 times higher PGE(2) levels in CSF compared with normal control subjects. That affected areas of the CNS are inflamed in ALS supports this. CSF PGE(2) measurement may be useful in monitoring treatment for ALS.

AB - Levels of the potent pro-inflammatory prostaglandin E-2 (PGE(2)) are elevated in postmortem spinal cords from patients with ALS, and inhibition of a key PGE(2)-synthesizing enzyme, cylcooxygenase-2, is neuroprotective in an in vitro model of ALS. The authors report that 82% of the patients with ALS studied had 2 to 10 times higher PGE(2) levels in CSF compared with normal control subjects. That affected areas of the CNS are inflamed in ALS supports this. CSF PGE(2) measurement may be useful in monitoring treatment for ALS.

KW - amyotrophic-lateral-sclerosis

KW - Parkinsons-disease

KW - cyclooxygenase-2

KW - model

M3 - Article

SN - 0028-3878

VL - 58

SP - 1277

EP - 1279

JO - Neurology

JF - Neurology

ER -

Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients

Abstract

Keywords

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