Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients

G. Almer, Peter Teismann, Z. Stevic, J. Halaschek-Wiener, L. Deecke, V. Kostic, S. Przedborski

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Levels of the potent pro-inflammatory prostaglandin E-2 (PGE(2)) are elevated in postmortem spinal cords from patients with ALS, and inhibition of a key PGE(2)-synthesizing enzyme, cylcooxygenase-2, is neuroprotective in an in vitro model of ALS. The authors report that 82% of the patients with ALS studied had 2 to 10 times higher PGE(2) levels in CSF compared with normal control subjects. That affected areas of the CNS are inflamed in ALS supports this. CSF PGE(2) measurement may be useful in monitoring treatment for ALS.

Original languageEnglish
Pages (from-to)1277-1279
Number of pages3
JournalNeurology
Volume58
Publication statusPublished - 2002

Keywords

  • amyotrophic-lateral-sclerosis
  • Parkinsons-disease
  • cyclooxygenase-2
  • model

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