Increased liver alanine in the tumour-bearing host. Altered levels of some enzymes involved in alanine metabolism

G A Goodlad, E Jaffray, K Loudon, C M Clark

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Abstract

A 2-fold increase in hepatic alanine concentration was observed in rats bearing a Walker 256 carcinoma growing sub-cutaneously. Decreases were observed in the activities of both cytosolic and mitochondrial isozyme forms of L-alanine-2-oxoglutarate aminotransferase. Activities of two enzymes involved in a secondary pathway of haem synthesis involving alanine, L-alanine-4,5-dioxovalerate aminotransferase and the NADP-requiring isozyme form of 4-oxo-5-hydroxyvalerate dehydrogenase were also reduced but there was no change in liver porphyrin concentration. L-alanine-glyoxalate aminotransferase activity was unaffected. The results are discussed in relation to the utilisation of alanine as a gluconeogenic substrate in the tumor-bearing host.

Original languageEnglish
Pages (from-to)279-87
Number of pages9
JournalBiochemistry International
Volume21
Issue number2
Publication statusPublished - 1990

Keywords

  • Alanine
  • Alanine Transaminase
  • Animals
  • Carcinoma 256, Walker
  • Cytosol
  • Female
  • Isoenzymes
  • Liver
  • Mitochondria, Liver
  • Rats
  • Rats, Inbred Strains
  • Transaminases

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