Abstract
A 2-fold increase in hepatic alanine concentration was observed in rats bearing a Walker 256 carcinoma growing sub-cutaneously. Decreases were observed in the activities of both cytosolic and mitochondrial isozyme forms of L-alanine-2-oxoglutarate aminotransferase. Activities of two enzymes involved in a secondary pathway of haem synthesis involving alanine, L-alanine-4,5-dioxovalerate aminotransferase and the NADP-requiring isozyme form of 4-oxo-5-hydroxyvalerate dehydrogenase were also reduced but there was no change in liver porphyrin concentration. L-alanine-glyoxalate aminotransferase activity was unaffected. The results are discussed in relation to the utilisation of alanine as a gluconeogenic substrate in the tumor-bearing host.
Original language | English |
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Pages (from-to) | 279-87 |
Number of pages | 9 |
Journal | Biochemistry International |
Volume | 21 |
Issue number | 2 |
Publication status | Published - 1990 |
Keywords
- Alanine
- Alanine Transaminase
- Animals
- Carcinoma 256, Walker
- Cytosol
- Female
- Isoenzymes
- Liver
- Mitochondria, Liver
- Rats
- Rats, Inbred Strains
- Transaminases