Increased neural response to social rejection in major depression

Poornima Kumar (Corresponding Author), Gordon D Waiter, Magda Dubois, Maarten Milders, Ian Reid, J. Douglas Steele

Research output: Contribution to journalArticle

18 Citations (Scopus)
4 Downloads (Pure)

Abstract

Background

Being a part of community is critical for survival and individuals with major depressive disorder (MDD) have a greater sensitivity to interpersonal stress that makes them vulnerable to future episodes. Social rejection is a critical risk factor for depression and it is said to increase interpersonal stress and thereby impairing social functioning. It is therefore critical to understand the neural correlates of social rejection in MDD.
Methods

To this end, we scanned 15 medicated MDD and 17 healthy individuals during a modified cyberball passing game, where participants were exposed to increasing levels of social exclusion. Neural responses to increasing social exclusion were investigated and compared between groups.
Results

We showed that compared to controls, MDD individuals exhibited greater amygdala, insula, and ventrolateral prefrontal cortex activation to increasing social exclusion and this correlated negatively with hedonic tone and self-esteem scores across all participants.
Conclusions

These preliminary results support the hypothesis that depression is associated with hyperactive response to social rejection. These findings highlight the importance of studying social interactions in depression, as they often lead to social withdrawal and isolation.
Original languageEnglish
Pages (from-to)1049-1056
Number of pages8
JournalDepression and Anxiety
Volume34
Issue number11
Early online date20 Jun 2017
DOIs
Publication statusPublished - Nov 2017

Fingerprint

Social Distance
Major Depressive Disorder
Depression
Social Isolation
Pleasure
Interpersonal Relations
Amygdala
Prefrontal Cortex
Self Concept

Keywords

  • amygdala
  • cyberball
  • insula
  • self-esteem
  • social exclusion

ASJC Scopus subject areas

  • Medicine(all)
  • Psychology(all)

Cite this

Increased neural response to social rejection in major depression. / Kumar, Poornima (Corresponding Author); Waiter, Gordon D; Dubois, Magda; Milders, Maarten; Reid, Ian; Steele, J. Douglas.

In: Depression and Anxiety, Vol. 34, No. 11, 11.2017, p. 1049-1056.

Research output: Contribution to journalArticle

Kumar, Poornima ; Waiter, Gordon D ; Dubois, Magda ; Milders, Maarten ; Reid, Ian ; Steele, J. Douglas. / Increased neural response to social rejection in major depression. In: Depression and Anxiety. 2017 ; Vol. 34, No. 11. pp. 1049-1056.
@article{d48c7c7a8caf4272a56f3d434cfb3f7b,
title = "Increased neural response to social rejection in major depression",
abstract = "BackgroundBeing a part of community is critical for survival and individuals with major depressive disorder (MDD) have a greater sensitivity to interpersonal stress that makes them vulnerable to future episodes. Social rejection is a critical risk factor for depression and it is said to increase interpersonal stress and thereby impairing social functioning. It is therefore critical to understand the neural correlates of social rejection in MDD.MethodsTo this end, we scanned 15 medicated MDD and 17 healthy individuals during a modified cyberball passing game, where participants were exposed to increasing levels of social exclusion. Neural responses to increasing social exclusion were investigated and compared between groups.ResultsWe showed that compared to controls, MDD individuals exhibited greater amygdala, insula, and ventrolateral prefrontal cortex activation to increasing social exclusion and this correlated negatively with hedonic tone and self-esteem scores across all participants.ConclusionsThese preliminary results support the hypothesis that depression is associated with hyperactive response to social rejection. These findings highlight the importance of studying social interactions in depression, as they often lead to social withdrawal and isolation.",
keywords = "amygdala, cyberball, insula, self-esteem, social exclusion",
author = "Poornima Kumar and Waiter, {Gordon D} and Magda Dubois and Maarten Milders and Ian Reid and Steele, {J. Douglas}",
year = "2017",
month = "11",
doi = "10.1002/da.22665",
language = "English",
volume = "34",
pages = "1049--1056",
journal = "Depression and Anxiety",
issn = "1091-4269",
publisher = "Wiley-Blackwell",
number = "11",

}

TY - JOUR

T1 - Increased neural response to social rejection in major depression

AU - Kumar, Poornima

AU - Waiter, Gordon D

AU - Dubois, Magda

AU - Milders, Maarten

AU - Reid, Ian

AU - Steele, J. Douglas

PY - 2017/11

Y1 - 2017/11

N2 - BackgroundBeing a part of community is critical for survival and individuals with major depressive disorder (MDD) have a greater sensitivity to interpersonal stress that makes them vulnerable to future episodes. Social rejection is a critical risk factor for depression and it is said to increase interpersonal stress and thereby impairing social functioning. It is therefore critical to understand the neural correlates of social rejection in MDD.MethodsTo this end, we scanned 15 medicated MDD and 17 healthy individuals during a modified cyberball passing game, where participants were exposed to increasing levels of social exclusion. Neural responses to increasing social exclusion were investigated and compared between groups.ResultsWe showed that compared to controls, MDD individuals exhibited greater amygdala, insula, and ventrolateral prefrontal cortex activation to increasing social exclusion and this correlated negatively with hedonic tone and self-esteem scores across all participants.ConclusionsThese preliminary results support the hypothesis that depression is associated with hyperactive response to social rejection. These findings highlight the importance of studying social interactions in depression, as they often lead to social withdrawal and isolation.

AB - BackgroundBeing a part of community is critical for survival and individuals with major depressive disorder (MDD) have a greater sensitivity to interpersonal stress that makes them vulnerable to future episodes. Social rejection is a critical risk factor for depression and it is said to increase interpersonal stress and thereby impairing social functioning. It is therefore critical to understand the neural correlates of social rejection in MDD.MethodsTo this end, we scanned 15 medicated MDD and 17 healthy individuals during a modified cyberball passing game, where participants were exposed to increasing levels of social exclusion. Neural responses to increasing social exclusion were investigated and compared between groups.ResultsWe showed that compared to controls, MDD individuals exhibited greater amygdala, insula, and ventrolateral prefrontal cortex activation to increasing social exclusion and this correlated negatively with hedonic tone and self-esteem scores across all participants.ConclusionsThese preliminary results support the hypothesis that depression is associated with hyperactive response to social rejection. These findings highlight the importance of studying social interactions in depression, as they often lead to social withdrawal and isolation.

KW - amygdala

KW - cyberball

KW - insula

KW - self-esteem

KW - social exclusion

U2 - 10.1002/da.22665

DO - 10.1002/da.22665

M3 - Article

VL - 34

SP - 1049

EP - 1056

JO - Depression and Anxiety

JF - Depression and Anxiety

SN - 1091-4269

IS - 11

ER -