Increased salicylate concentrations in urine of human volunteers after consumption of cranberry juice

Garry G Duthie, Janet A M Kyle, Alison McE Jenkinson, Susan J Duthie, Gwen J Baxter, John R Paterson

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The aim of this study was to assess whether regular consumption of cranberry juice results in elevations in urinary salicylate concentrations in persons not taking salicylate drugs. Two groups of healthy female subjects (11/group) matched for age, weight, and height consumed 250 mL of either cranberry juice or a placebo solution three times a day (i.e., 750 mL/day) for 2 weeks. At weekly intervals, salicylic acid and salicyluric acid (the major urinary metabolite of salicylic acid) concentrations were determined in urine by HPLC with electrochemical detection. Concentrations of salicylic acid in plasma were also determined. Consumption of cranberry juice was associated with a marked increase (p <0.001) of salicyluric and salicylic acids in urine within 1 week of the intervention. After 2 weeks, there was also a small but significant (p <0.05) increase in salicylic acid in plasma. The regular consumption of cranberry juice results in the increased absorption of salicylic acid, an anti-inflammatory compound that may benefit health.
Original languageEnglish
Pages (from-to)2897-2900
Number of pages4
JournalJournal of Agricultural and Food Chemistry
Volume53
Issue number8
DOIs
Publication statusPublished - Apr 2005

Keywords

  • salicylic acid
  • salicyluric acid
  • cranberry juice
  • salicylates
  • prevent colorectal adenomas
  • low-dose aspirin
  • randomized-trial
  • GC-MS
  • acid
  • cancer
  • foods
  • nonvegetarians
  • identification
  • vegetarians

Cite this

Increased salicylate concentrations in urine of human volunteers after consumption of cranberry juice. / Duthie, Garry G; Kyle, Janet A M; Jenkinson, Alison McE; Duthie, Susan J; Baxter, Gwen J; Paterson, John R.

In: Journal of Agricultural and Food Chemistry, Vol. 53, No. 8, 04.2005, p. 2897-2900.

Research output: Contribution to journalArticle

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abstract = "The aim of this study was to assess whether regular consumption of cranberry juice results in elevations in urinary salicylate concentrations in persons not taking salicylate drugs. Two groups of healthy female subjects (11/group) matched for age, weight, and height consumed 250 mL of either cranberry juice or a placebo solution three times a day (i.e., 750 mL/day) for 2 weeks. At weekly intervals, salicylic acid and salicyluric acid (the major urinary metabolite of salicylic acid) concentrations were determined in urine by HPLC with electrochemical detection. Concentrations of salicylic acid in plasma were also determined. Consumption of cranberry juice was associated with a marked increase (p <0.001) of salicyluric and salicylic acids in urine within 1 week of the intervention. After 2 weeks, there was also a small but significant (p <0.05) increase in salicylic acid in plasma. The regular consumption of cranberry juice results in the increased absorption of salicylic acid, an anti-inflammatory compound that may benefit health.",
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AB - The aim of this study was to assess whether regular consumption of cranberry juice results in elevations in urinary salicylate concentrations in persons not taking salicylate drugs. Two groups of healthy female subjects (11/group) matched for age, weight, and height consumed 250 mL of either cranberry juice or a placebo solution three times a day (i.e., 750 mL/day) for 2 weeks. At weekly intervals, salicylic acid and salicyluric acid (the major urinary metabolite of salicylic acid) concentrations were determined in urine by HPLC with electrochemical detection. Concentrations of salicylic acid in plasma were also determined. Consumption of cranberry juice was associated with a marked increase (p <0.001) of salicyluric and salicylic acids in urine within 1 week of the intervention. After 2 weeks, there was also a small but significant (p <0.05) increase in salicylic acid in plasma. The regular consumption of cranberry juice results in the increased absorption of salicylic acid, an anti-inflammatory compound that may benefit health.

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KW - low-dose aspirin

KW - randomized-trial

KW - GC-MS

KW - acid

KW - cancer

KW - foods

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KW - identification

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