Increased Variation in Body Weight and Food Intake Is Related to Increased Dietary Fat but Not Increased Carbohydrate or Protein in Mice

Yingga Wu; Sumei Hu; Dengbao Yang; Li Li; Baoguo Li; Lu Wang; Min Li; Guanlin Wang; Jianbo Li; Yanchao Xu; Xueying Zhang; Chaoqun Niu; John R Speakman

doi:10.3389/fnut.2022.835536

Increased Variation in Body Weight and Food Intake Is Related to Increased Dietary Fat but Not Increased Carbohydrate or Protein in Mice

Yingga Wu, Sumei Hu, Dengbao Yang, Li Li, Baoguo Li, Lu Wang, Min Li, Guanlin Wang, Jianbo Li, Yanchao Xu, Xueying Zhang, Chaoqun Niu, John R Speakman^* (Corresponding Author)

^*Corresponding author for this work

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Abstract

A variety of inbred mouse strains have been used for research in metabolic disorders. Despite being inbred, they display large inter-individual variability for many traits like food intake and body weight. However, the relationship between dietary macronutrients and inter-individual variation in body weight and food intake of different mouse strains is still unclear. We investigated the association between macronutrient content of the diet and variations in food intake, body composition, and glucose tolerance by exposing five different mouse strains (C57BL/6, BALB/c, C3H, DBA/2, and FVB) to 24 different diets with variable protein, fat, and carbohydrate contents. We found only increasing dietary fat, but not protein or carbohydrate had a significant association (positive) with variation in both food intake and body weight. The highest variation in both body weight and food intake occurred with 50% dietary fat. However, there were no significant relationships between the variation in fat and lean mass with dietary protein, fat, or carbohydrate levels. In addition, none of the dietary macronutrients had significant impacts on the variation in glucose tolerance ability in C57BL/6 mice. In conclusion, the variations in food intake and body weight changes increased with the elevation of dietary fat levels.

Original language	English
Article number	835536
Number of pages	9
Journal	Frontiers in Nutrition
Volume	9
DOIs	https://doi.org/10.3389/fnut.2022.835536 https://doi.org/10.3389/fnut.2022.1049766
Publication status	Published - 8 Mar 2022

Bibliographical note

Funding
This study was funded by the National Key R&D Program of China (2019YFA0801900) to JS and the Postdoctoral Innovation Fund (2021) to YW. The original diet exposure experiment was funded by the Chinese Academy of Sciences Strategic Program (XDB13030100). JS was also supported during this work by a PIFI professorial fellowship from CAS and a Wolfson merit award from the UK Royal Society.

CORRECTION article Front. Nutr., 21 October 2022 Sec. Nutrition and Metabolism
https://doi.org/10.3389/fnut.2022.1049766
Corrigendum: Increased variation in body weight and food intake is related to increased dietary fat but not increased carbohydrate or protein in mice

Data Availability Statement

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

Keywords

Protein
Fat
Carbohydrate
Mice
Strain
Variation

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Copyright © 2022 Wu, Hu, Yang, Li, Li, Wang, Li, Wang, Li, Xu, Zhang, Niu and Speakman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Cite this

Wu, Y., Hu, S., Yang, D., Li, L., Li, B., Wang, L., Li, M., Wang, G., Li, J., Xu, Y., Zhang, X., Niu, C., & Speakman, J. R. (2022). Increased Variation in Body Weight and Food Intake Is Related to Increased Dietary Fat but Not Increased Carbohydrate or Protein in Mice. Frontiers in Nutrition, 9, Article 835536. https://doi.org/10.3389/fnut.2022.835536, https://doi.org/10.3389/fnut.2022.1049766

Wu, Y, Hu, S, Yang, D, Li, L, Li, B, Wang, L, Li, M, Wang, G, Li, J, Xu, Y, Zhang, X, Niu, C & Speakman, JR 2022, 'Increased Variation in Body Weight and Food Intake Is Related to Increased Dietary Fat but Not Increased Carbohydrate or Protein in Mice', Frontiers in Nutrition, vol. 9, 835536. https://doi.org/10.3389/fnut.2022.835536, https://doi.org/10.3389/fnut.2022.1049766

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title = "Increased Variation in Body Weight and Food Intake Is Related to Increased Dietary Fat but Not Increased Carbohydrate or Protein in Mice",

abstract = "A variety of inbred mouse strains have been used for research in metabolic disorders. Despite being inbred, they display large inter-individual variability for many traits like food intake and body weight. However, the relationship between dietary macronutrients and inter-individual variation in body weight and food intake of different mouse strains is still unclear. We investigated the association between macronutrient content of the diet and variations in food intake, body composition, and glucose tolerance by exposing five different mouse strains (C57BL/6, BALB/c, C3H, DBA/2, and FVB) to 24 different diets with variable protein, fat, and carbohydrate contents. We found only increasing dietary fat, but not protein or carbohydrate had a significant association (positive) with variation in both food intake and body weight. The highest variation in both body weight and food intake occurred with 50% dietary fat. However, there were no significant relationships between the variation in fat and lean mass with dietary protein, fat, or carbohydrate levels. In addition, none of the dietary macronutrients had significant impacts on the variation in glucose tolerance ability in C57BL/6 mice. In conclusion, the variations in food intake and body weight changes increased with the elevation of dietary fat levels.",

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author = "Yingga Wu and Sumei Hu and Dengbao Yang and Li Li and Baoguo Li and Lu Wang and Min Li and Guanlin Wang and Jianbo Li and Yanchao Xu and Xueying Zhang and Chaoqun Niu and Speakman, {John R}",

note = "Funding This study was funded by the National Key R&D Program of China (2019YFA0801900) to JS and the Postdoctoral Innovation Fund (2021) to YW. The original diet exposure experiment was funded by the Chinese Academy of Sciences Strategic Program (XDB13030100). JS was also supported during this work by a PIFI professorial fellowship from CAS and a Wolfson merit award from the UK Royal Society. CORRECTION article Front. Nutr., 21 October 2022 Sec. Nutrition and Metabolism https://doi.org/10.3389/fnut.2022.1049766 Corrigendum: Increased variation in body weight and food intake is related to increased dietary fat but not increased carbohydrate or protein in mice",

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AU - Li, Min

AU - Wang, Guanlin

AU - Li, Jianbo

AU - Xu, Yanchao

AU - Zhang, Xueying

AU - Niu, Chaoqun

AU - Speakman, John R

N1 - Funding This study was funded by the National Key R&D Program of China (2019YFA0801900) to JS and the Postdoctoral Innovation Fund (2021) to YW. The original diet exposure experiment was funded by the Chinese Academy of Sciences Strategic Program (XDB13030100). JS was also supported during this work by a PIFI professorial fellowship from CAS and a Wolfson merit award from the UK Royal Society. CORRECTION article Front. Nutr., 21 October 2022 Sec. Nutrition and Metabolism https://doi.org/10.3389/fnut.2022.1049766 Corrigendum: Increased variation in body weight and food intake is related to increased dietary fat but not increased carbohydrate or protein in mice

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N2 - A variety of inbred mouse strains have been used for research in metabolic disorders. Despite being inbred, they display large inter-individual variability for many traits like food intake and body weight. However, the relationship between dietary macronutrients and inter-individual variation in body weight and food intake of different mouse strains is still unclear. We investigated the association between macronutrient content of the diet and variations in food intake, body composition, and glucose tolerance by exposing five different mouse strains (C57BL/6, BALB/c, C3H, DBA/2, and FVB) to 24 different diets with variable protein, fat, and carbohydrate contents. We found only increasing dietary fat, but not protein or carbohydrate had a significant association (positive) with variation in both food intake and body weight. The highest variation in both body weight and food intake occurred with 50% dietary fat. However, there were no significant relationships between the variation in fat and lean mass with dietary protein, fat, or carbohydrate levels. In addition, none of the dietary macronutrients had significant impacts on the variation in glucose tolerance ability in C57BL/6 mice. In conclusion, the variations in food intake and body weight changes increased with the elevation of dietary fat levels.

AB - A variety of inbred mouse strains have been used for research in metabolic disorders. Despite being inbred, they display large inter-individual variability for many traits like food intake and body weight. However, the relationship between dietary macronutrients and inter-individual variation in body weight and food intake of different mouse strains is still unclear. We investigated the association between macronutrient content of the diet and variations in food intake, body composition, and glucose tolerance by exposing five different mouse strains (C57BL/6, BALB/c, C3H, DBA/2, and FVB) to 24 different diets with variable protein, fat, and carbohydrate contents. We found only increasing dietary fat, but not protein or carbohydrate had a significant association (positive) with variation in both food intake and body weight. The highest variation in both body weight and food intake occurred with 50% dietary fat. However, there were no significant relationships between the variation in fat and lean mass with dietary protein, fat, or carbohydrate levels. In addition, none of the dietary macronutrients had significant impacts on the variation in glucose tolerance ability in C57BL/6 mice. In conclusion, the variations in food intake and body weight changes increased with the elevation of dietary fat levels.

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Increased Variation in Body Weight and Food Intake Is Related to Increased Dietary Fat but Not Increased Carbohydrate or Protein in Mice

Abstract

Bibliographical note

Data Availability Statement

Keywords

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